4-MPD
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 4 corroborating sources
- 3 ROAs with full dose ladders
- duration data present
- 18 combo interactions documented
- classified Tentative
- classified Research-chemical
- 4 corroborating sources
- 3 ROAs with full dose ladders
- duration data present
- 18 combo interactions documented
- classified Tentative
- classified Research-chemical
Aliases: 4-methylpentedrone
Summary
4-MPD is the para-methyl analogue of pentedrone and a higher homologue of mephedrone. It appears as an off-white crystalline powder, soluble in water and ethanol; aqueous solutions degrade within days due to ฮฒ-keto hydrolysis - store dry, airtight and cool. Acts primarily as a DAT and NET reuptake inhibitor with partial SERT substrate activity.
Dose Information
Dose basis. Ranges are compiled from user reports; purity varies between batches. Always weigh with a 0.001 g (mg) scale. Avoid redosing within the first 60โ90 minutes to prevent stacking. User-reported. Finely crush; use your own sterile straw; rinse nose with water before/after to reduce tissue damage. Volumetric sprays (e.g., 5 mg per spray) can reduce dosing errors. (Dose figures and this note are from Drugs.Wiki.)
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 40-80mg | 80-180mg | 180-275mg | 275mg+ |
| Insufflated | 15-25mg | 25-60mg | 60-90mg | 90mg+ |
| Vaporized | 5-15mg | 15-35mg | 35-60mg | 60mg+ |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 10-30 min | 15-30 min | 0.8-2 hrs | 1-2 hrs | 2.22-5 hrs |
| Insufflated | 2-10 min | 5-15 min | 0.8-2 hrs | 1-2 hrs | 1.91-4.42 hrs |
| Vaporized | 1 min | 1-5 min | 0.8-2 hrs | 1-2 hrs | 1.84-4.1 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong anxiety/jitters with moderate euphoria, low stimulation
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track 4-MPD there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
4-MPD Source: SubstanceSearch (substancesearch.com) Oral dose (mg): threshold 15-25 ยท light 40-80 ยท common 80-180 ยท strong 180-275 ยท heavy 275+ Insufflated dose (mg): threshold 5-10 ยท light 15-25 ยท common 25-60 ยท strong 60-90 ยท heavy 90+ Vaporized dose (mg): threshold 2-5 ยท light 5-15 ยท common 15-35 ยท strong 35-60 ยท heavy 60+ Oral duration: onset 10-30m ยท come-up 15-30m ยท peak 0.8-2h ยท offset 1-2h ยท total 2.22-5h ยท after-effects 1-4h Insufflated duration: onset 2-10m ยท come-up 5-15m ยท peak 0.8-2h ยท offset 1-2h ยท total 1.91-4.42h ยท after-effects 1-4h Vaporized duration: onset 1m ยท come-up 1-5m ยท peak 0.8-2h ยท offset 1-2h ยท total 1.84-4.1h ยท after-effects 1-4h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 130 mg (Oral).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session โ the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Model is heuristic from stimulant user reports; tolerance rises quickly with consecutive redosing or multiโday use, then decays over 1โ2+ weeks. Crossโtolerance within cathinones is likely; across classes is partial. Data quality is limited to forum/anecdotal sources.
Cross-Tolerances
Effects
- Stimulation
- Teeth grinding
- Sweating
- Vasoconstriction
- Restlessness
- Insomnia
- Increased heart rate
- Pupil dilation
- Nausea
- Sedation
- Euphoria
- Increased sociability
- Mild empathy
- Enhanced music appreciation
- Cognitive euphoria
- Anxiety
- Paranoia
- Anhedonia
- Dysphoria
- Time distortion
- Color enhancement
- Increased music appreciation
- Brightened colour
- Appetite suppression
- Light sensitivity
- Disinhibition
- Dehydration
- Sexual arousal
- Dulled perception
- Drifting
Combinations
Cross-Check 4-MPD with another substanceHelpful Links
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