Summary
4-MPD is the para-methyl analogue of pentedrone and a higher homologue of mephedrone. It appears as an off-white crystalline powder, soluble in water and ethanol; aqueous solutions degrade within days due to ฮฒ-keto hydrolysis - store dry, airtight and cool. Acts primarily as a DAT and NET reuptake inhibitor with partial SERT substrate activity. Typical acute adverse effects include tachycardia (100-130 bpm), hypertension (>140/95 mmHg), jaw clenching, peripheral vasoconstriction and hyperthermia. A fatal poly-intoxication case in a chemsex context (plasma 4-MPD 1285 ng/mL) has been documented.
Dose Information
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects |
|---|---|---|---|---|---|
| Oral | 10-30 min | 15-30 min | 0.8-2 hrs | 1-2 hrs | 1-4 hrs |
| Insufflated | 2-10 min | 5-15 min | 0.8-2 hrs | 1-2 hrs | 1-4 hrs |
| Vaporized | 1 min | 1-5 min | 0.8-2 hrs | 1-2 hrs | 1-4 hrs |
Tolerance
Build-up
develops rapidly, often within a single session; compulsive redosing common
Reset
a few days for acute tolerance
Effects
Positive
- Stimulation
Negative
- Teeth grinding
- Sweating
- Vasoconstriction
- Restlessness
- Insomnia
- Increased heart rate
- Pupil dilation
- Nausea
- Sedation
Positive
- Euphoria
- Increased sociability
- Mild empathy
- Enhanced music appreciation
- Cognitive euphoria
Negative
- Anxiety
- Paranoia
- Anhedonia
- Dysphoria
- Time distortion
Positive
- Color enhancement
- Increased music appreciation
- Brightened colour
Negative
- Appetite suppression
- Light sensitivity
- Disinhibition
- Dehydration
- Sexual arousal
- Dulled perception
- Drifting