4-MPD
Aliases: 4-methylpentedrone
Summary
4-MPD is the para-methyl analogue of pentedrone and a higher homologue of mephedrone. It appears as an off-white crystalline powder, soluble in water and ethanol; aqueous solutions degrade within days due to Ξ²-keto hydrolysis - store dry, airtight and cool. Acts primarily as a DAT and NET reuptake inhibitor with partial SERT substrate activity.
Dose Information
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset |
|---|---|---|---|---|
| Oral | 10-30 min | 15-30 min | 0.8-2 hrs | 1-2 hrs |
| Insufflated | 2-10 min | 5-15 min | 0.8-2 hrs | 1-2 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong anxiety/jitters with moderate euphoria, low stimulation
Tolerance
Tolerance Decay
Model is heuristic from stimulant user reports; tolerance rises quickly with consecutive redosing or multiβday use, then decays over 1β2+ weeks. Crossβtolerance within cathinones is likely; across classes is partial. Data quality is limited to forum/anecdotal sources.
Cross-Tolerances
Effects
- Stimulation
- Teeth grinding
- Sweating
- Vasoconstriction
- Restlessness
- Insomnia
- Increased heart rate
- Pupil dilation
- Nausea
- Sedation
- Euphoria
- Increased sociability
- Mild empathy
- Enhanced music appreciation
- Cognitive euphoria
- Anxiety
- Paranoia
- Anhedonia
- Dysphoria
- Time distortion
- Color enhancement
- Increased music appreciation
- Brightened colour
- Appetite suppression
- Light sensitivity
- Disinhibition
- Dehydration
- Sexual arousal
- Dulled perception
- Drifting