4-MPD
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 3 corroborating sources
- 3 ROAs with full dose ladders
- duration data present
- 18 combo interactions documented
- classified Tentative
- classified Research-chemical
- 3 corroborating sources
- 3 ROAs with full dose ladders
- duration data present
- 18 combo interactions documented
- classified Tentative
- classified Research-chemical
Aliases: 4-methylpentedrone
Summary
4-MPD is the para-methyl analogue of pentedrone and a higher homologue of mephedrone. It appears as an off-white crystalline powder, soluble in water and ethanol; aqueous solutions degrade within days due to ฮฒ-keto hydrolysis - store dry, airtight and cool. Acts primarily as a DAT and NET reuptake inhibitor with partial SERT substrate activity.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 40-80mg | 80-180mg | 180-275mg | 275mg+ |
| Insufflated | 15-25mg | 25-60mg | 60-90mg | 90mg+ |
| Vaporized | 5-15mg | 15-35mg | 35-60mg | 60mg+ |
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Oral | 10-30 min | 0.8-2 hrs | 1-2 hrs | 3-5 hrs |
| Insufflated | 10-30 min | 0.8-2 hrs | 1-2 hrs | 3-5 hrs |
| Vaporized | 10-30 min | 0.8-2 hrs | 1-2 hrs | 3-5 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong anxiety/jitters with moderate euphoria, low stimulation
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session โ the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Model is heuristic from stimulant user reports; tolerance rises quickly with consecutive redosing or multiโday use, then decays over 1โ2+ weeks. Crossโtolerance within cathinones is likely; across classes is partial. Data quality is limited to forum/anecdotal sources.
Cross-Tolerances
Effects
- Stimulation
- Teeth grinding
- Sweating
- Vasoconstriction
- Restlessness
- Insomnia
- Increased heart rate
- Pupil dilation
- Nausea
- Sedation
- Euphoria
- Increased sociability
- Mild empathy
- Enhanced music appreciation
- Cognitive euphoria
- Anxiety
- Paranoia
- Anhedonia
- Dysphoria
- Time distortion
- Color enhancement
- Increased music appreciation
- Brightened colour
- Appetite suppression
- Light sensitivity
- Disinhibition
- Dehydration
- Sexual arousal
- Dulled perception
- Drifting
Combinations
Cross-Check 4-MPD with another substanceHelpful Links
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