5-IAI
Aliases: Hdep-28, Ethylnaphthidate, 5-iodo-2-aminoindan, 5iai
Summary
Animal studies show markedly lower serotonergic neurotoxicity than p-iodoamphetamine, but single 40 mg/kg doses still reduced hippocampal 5-HT uptake sites. Human anecdotal reports indicate 5-IAI is less euphoric and stimulating than MDMA, with some users reporting dysphoria, anxiety, and hallucinations at various doses. Many products sold as 5-IAI between 2010-2013 were mislabeled or adulterated; reagent testing is essential.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 15-30mg | 30-50mg | 50-100mg | 100mg+ |
| Insufflated | 5-15mg | 15-35mg | 35-60mg | 60mg+ |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset |
|---|---|---|---|---|
| Oral | 20-45 min | 30-60 min | 1-3 hrs | 2-3 hrs |
| Insufflated | 5-15 min | 15-30 min | 1-2.5 hrs | 2-3 hrs |
| Rectal | 10-20 min | 20-40 min | 1-2.5 hrs | 2-3 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Mild auditory effects with low body load, visuals, and headspace
Strong sensory enhancement with moderate euphoria, mild empathy and stimulation
Moderate anxiety/jitters with mild euphoria, low stimulation and focus
Tolerance
Tolerance Decay
Pattern extrapolated from MDMA‑like releasers and aminoindane reports: acute tachyphylaxis within a session, partial tolerance over 1–2 weeks, and return to near‑baseline by ~4–6 weeks with abstinence. Data quality low due to absence of controlled human studies.
Cross-Tolerances
Effects
- Stimulation
- Increased energy/alertness
- Teeth grinding
- Pupil dilation
- Increased perspiration
- Weight loss
- Sweating
- Decreased need for sleep
- Decreased appetite
- Distrubed sleep patterns
- Bruxia
- Empathy and sociability
- Emotion enhancement
- Cognitive enhancement
- Euphoria
- Increased sociability
- Mood lift
- Dysphoria
- Anxiety
- Agressiveness
- Talkativeness
- Excessive talking
- Moodiness
- Tactile enhancement
- Music enhancement
- Visual enhancement
- Increased music appreciation
- Appetite suppression
- Dehydration
- Light sensitivity
- Increase sexuality
- Visual and audiotory hallucinations itchiness
- Increased sexuality