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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    5-MAPDB

    Aliases: 5mapdb

    Psychedelic Stimulant Empathogen Research-chemical

    Summary TheDrug.Wiki TripSit

    5-MAPDB is a dihydrobenzofuran entactogen first characterized by Monte et al. (1993) and pharmacologically profiled by Rickli et al. (2015).

    Dose Information TheDrug.Wiki TripSit

    ROA Light Common Strong Heavy
    Oral 50-75mg 75-120mg 120-150mg 150mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 45-70 min 30-60 min 2-4 hrs 1-2 hrs 2-4 hrs 4.2-8.2 hrs
    Insufflated 5-15 min 15-30 min 2-4 hrs 1-2 hrs 2-4 hrs 3.3-6.8 hrs
    Rectal 5-15 min 15-30 min 2-4 hrs 1-2 hrs 2-4 hrs 3.3-6.8 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 2.0
    Light 2/10

    Mild auditory effects and body load with low visuals

    Visual Intensity ×3
    2
    tracers
    Headspace Depth ×3
    0
    Auditory Effects ×1
    4
    enhanced music appreciation
    ⚠ Body Load / Somatic Effects ×1
    4
    bruxism jaw clenching sweating
    Empathogen 6.3
    Strong 6/10

    Strong sensory enhancement with moderate empathy, mild euphoria, low stimulation

    Empathy / Social Openness ×3
    7
    empathy emotional openness increased sociability
    Euphoria / Mood Elevation ×2
    5
    euphoria mood lift
    Stimulation ×1
    3
    stimulation
    Sensory Enhancement ×1
    10
    enhanced music appreciation enhanced tactile sensation tactile enhancement increased libido
    Stimulant 2.9
    Light+ 3/10

    Moderate anxiety/jitters with mild euphoria, low stimulation

    Stimulation / Energy ×3
    3
    stimulation
    Euphoria / Mood Lift ×2
    5
    euphoria mood lift
    Focus / Productivity ×2
    0
    ⚠ Anxiety / Jitters ×1
    6
    bruxism jaw clenching sweating
    Based on reports from:
    Erowid Experience Reports PsychonautWiki 5-MAPDB
    View methodology →

    Tolerance

    Build-up develops rapidly after a single use
    Reset 7–14 days for baseline

    Tolerance Decay

    Full tolerance 1h Half tolerance 10d Baseline ~14d

    Effects TheDrug.Wiki TripSit

    Positive
    • Stimulation
    • Increased energy/alertness
    Negative
    • Pupil dilation
    • Bruxism
    • Jaw clenching
    • Sweating
    • Insomnia during comedown
    • Weight loss
    Neutral
    • Difficulty urinating
    • Reduced appetite
    • Decreased need for sleep
    • Decreased appetite
    • Distrubed sleep patterns
    • Bruxia
    Positive
    • Euphoria
    • Empathy
    • Emotional openness
    • Increased sociability
    • Enhanced music appreciation
    • Mood lift
    Negative
    • Next-day lethargy or low mood
    • Agressiveness
    Neutral
    • Excessive talking
    • Moodiness
    Positive
    • Enhanced tactile sensation
    • Mild visual enhancement
    • Tactile enhancement
    • Increased music appreciation
    • Bodily control enhancement
    • Increased libido
    • Tracers
    Negative
    • Light sensitivity
    Neutral
    • Increase sexuality
    • Visual and audiotory hallucinations itchiness

    Combinations TripSit

    5-MAPDB's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 TripSit 📖 PsychonautWiki