5-MAPDB Stats & Data
5mapdb
NPS DataHub
MW191.27
FormulaC12H17NO
CAS1354631-78-9
IUPAC1-(2,3-dihydro-1-benzofuran-5-yl)-N-methylpropan-2-amine
SMILES
CNC(C)Cc1ccc2OCCc2c1InChIKey
PLQTZOCLUHHCOI-UHFFFAOYSA-N
Psychoactive Class
Psychedelic / Stimulant
Receptor Profile
Receptor Actions
Agonists
Partial 5-HT2A receptor agonist
Partial 5-HT2B receptor agonist
Other
Serotonin-dopamine-norepinephrine releasing agent (SNDRA)
Relatively selective serotonin releaser with weaker dopamine and norepinephrine activity
Effect Profile
Curated
Psychedelic
2.0
Mild auditory effects and body load with low visuals
Visual Intensity×3
2
Headspace Depth×3
0
Auditory Effects×1
4
Body Load / Somatic Effects×1
4
Empathogen
6.3
Strong sensory enhancement with moderate empathy, mild euphoria, low stimulation
Empathy / Social Openness×3
7
Euphoria / Mood Elevation×2
5
Stimulation×1
3
Sensory Enhancement×1
10
Stimulant
2.9
Moderate anxiety/jitters with mild euphoria, low stimulation
Stimulation / Energy×3
3
Euphoria / Mood Lift×2
5
Focus / Productivity×2
0
Anxiety / Jitters×1
6
Based on reports from:
Tolerance & Pharmacokinetics
drugs.wikiTolerance Decay
Full tolerance
1h
Half tolerance
10d
Baseline
~14d
References
Data Sources
Cited References
- ACMD UK, 'Benzofuran Report' (2014) – Annex on 5-MAPDB
- Bluelight discussion thread: '5-MAPDB – dosage & effects'
- Erowid: Experience Vaults – 5-MAPDB Reports (accessed 2025)
- Monte et al. (1993) Synthesis and pharmacological examination of benzofuran, indan, and tetralin analogues
- Rickli et al. (2015) Pharmacological profile of novel psychoactive benzofurans
- Shimshoni et al. (2017) Pharmacological evaluation of 5-MAPDB and related analogues
- Monte et al. (2013) Synthesis and characterization of MAPDB isomers
- Bluelight discussion thread: ‘5-MAPDB – dosage & effects’