5-MeO-DMT
Aliases: Toad, Bufo, 5-meo, Toads, Jaguar, 5meodmt, 5meo, 5-medmt
Categories
Summary
5-MeO-DMT is an extremely potent, fast-acting psychedelic tryptamine known for producing intense mystical experiences with minimal visual effects. Unlike N,N-DMT, 5-MeO-DMT is approximately 4-20 times more potent and carries greater safety concerns, including several documented fatalities. It preferentially activates 5-HT1A receptors over 5-HT2A receptors, making it an atypical psychedelic. The substance produces profound ego dissolution and non-dual states. Accurate dosing with a milligram scale is critical due to steep dose-response curve.
Perspectives
“I felt it in a minute—not really light head, but the head feels close to the lower parts of the body—close to the ground—knees weak—distinct shakes. I peaked at 2 or three minutes. It was quite intense, but not the max of DMT at 30 milligrams and no sensory close-out. Slight nausea on the drop-off—I am glad I had not eaten anything. Overall comparison to DMT, more potent, slightly faster, but like DMT is largely a simple, stoning drug with no sensory contribution, no intellectual contribution. It’s greatest contribution might be to provide a subject the vocabulary of an altered state of consciousness so that, with interesting and constructive drugs, these effects will be familiar, and thus not distractions.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Vaporized | 3-6mg | 6-12mg | 12-20mg | 20mg+ |
| Insufflated | 5-8mg | 8-15mg | 15-25mg | 15mg+ |
| Smoked | 3-6mg | 6-12mg | 12-20mg | 20mg+ |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects | Total |
|---|---|---|---|---|---|---|
| Vaporized | 0-1 min | 1-1 min | 4-19 min | 10-25 min | 1.0-2.0 hrs | - |
| Insufflated | 3-7 min | 4-15 min | 30-45 min | 15-30 min | 1.0-3.0 hrs | 2.0-3.0 hrs |
| Oral | 10-30 min | 19-40 min | 30-90 min | 1.0-2.0 hrs | 1.0-3.0 hrs | - |
| Smoked | 0 min | 0 min | 6-12 min | 12-18 min | 12-60 min | 30 min |
Tolerance
Effects
- Physical euphoria
- Nausea
- Bodily pressures
- Pupil dilation
- Skin flushing
- Temperature regulation suppression
- Respiratory depression
- Muscle tremors
- Muscle twitching
- Spontaneous bodily sensations
- Muscle contractions
- Unity and interconnectedness
- Mystical experiences
- Conceptual thinking
- Euphoria
- Analysis enhancement
- Emotion enhancement
- Mindfulness
- Rejuvenation
- Catharsis
- Thought connectivity
- Wakefulness
- Anxiety
- Memory suppression
- Motor control loss
- Overwhelming fear
- Panic
- Amnesia
- Delusions
- Delusion
- Confusion
- Ego death
- Time distortion
- Experience of "the void"
- Recursion
- Subconscious communication
- Physical autonomy
- Perception of predeterminism
- Emotion intensification
- Perception of self-design
- Perception of eternalism
- Perception of bodily lightness
- Auditory enhancement
- Bodily control enhancement
- Colour enhancement
- Colour shifting
- Tactile enhancement
- Visual acuity enhancement
- Color shifting
- Auditory acuity enhancement
- Spatial disorientation
- Visual acuity suppression
- Auditory distortion
- Powerful rushing of sensation
- Auditory hallucinations
- Changes in gravity
- Drifting
- Environmental orbism
- Perception of increased weight
- Auditory hallucination
- Changes in felt gravity
- Changes in felt bodily form
- Perception of bodily heaviness
- Tactile intensification
Combinations
PiHKAL / TiHKAL
“I felt it in a minute—not really light head, but the head feels close to the lower parts of the body—close to the ground—knees weak—distinct shakes. I peaked at 2 or three minutes. It was quite intense, but not the max of DMT at 30 milligrams and no sensory close-out. Slight nausea on the drop-off—I am glad I had not eaten anything. Overall comparison to DMT, more potent, slightly faster, but like DMT is largely a simple, stoning drug with no sensory contribution, no intellectual contribution. It’s greatest contribution might be to provide a subject the vocabulary of an altered state of consciousness so that, with interesting and constructive drugs, these effects will be familiar, and thus not distractions.”