5-MeO-DMT
Aliases: Toad, Bufo, 5-meo, Toads, Jaguar, 5meodmt, 5meo, 5-medmt
Summary
5-MeO-DMT is an extremely potent, fast-acting psychedelic tryptamine known for producing intense mystical experiences with minimal visual effects. Unlike N,N-DMT, 5-MeO-DMT is approximately 4-20 times more potent and carries greater safety concerns, including several documented fatalities. It preferentially activates 5-HT1A receptors over 5-HT2A receptors, making it an atypical psychedelic.
Perspectives
“I felt it in a minute—not really light head, but the head feels close to the lower parts of the body—close to the ground—knees weak—distinct shakes. I peaked at 2 or three minutes. It was quite intense, but not the max of DMT at 30 milligrams and no sensory close-out. Slight nausea on the drop-off—I am glad I had not eaten anything. Overall comparison to DMT, more potent, slightly faster, but like DMT is largely a simple, stoning drug with no sensory contribution, no intellectual contribution. It’s greatest contribution might be to provide a subject the vocabulary of an altered state of consciousness so that, with interesting and constructive drugs, these effects will be familiar, and thus not distractions.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Vaporized | 3-6mg | 6-12mg | 12-20mg | 20mg+ |
| Insufflated | 5-8mg | 8-15mg | 15-25mg | 15mg+ |
| Smoked | 3-6mg | 6-12mg | 12-20mg | 20mg+ |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Insufflated | 3-7 min | 4-15 min | 30-45 min | 15-30 min | 2-3 hrs |
| Oral | 10-30 min | 19-40 min | 30-90 min | 1-2 hrs | - |
Effect Profile
432 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Validated against 374 Erowid trip reports
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong visuals, headspace, auditory effects, and body load
Tolerance
Tolerance Decay
Users frequently report marked acute tolerance if re-dosed within the same session; effects are often blunted or dysphoric. Cross‑tolerance with other serotonergic psychedelics is plausible via 5‑HT2A down‑regulation, but quantitative data are limited; estimates here are conservative and anecdotal.
Cross-Tolerances
Effects
Aggregated from 374 Erowid and 58 Bluelight experience reports
Positive Effects 56
Adverse Effects 58
Combinations
PiHKAL / TiHKAL
“I felt it in a minute—not really light head, but the head feels close to the lower parts of the body—close to the ground—knees weak—distinct shakes. I peaked at 2 or three minutes. It was quite intense, but not the max of DMT at 30 milligrams and no sensory close-out. Slight nausea on the drop-off—I am glad I had not eaten anything. Overall comparison to DMT, more potent, slightly faster, but like DMT is largely a simple, stoning drug with no sensory contribution, no intellectual contribution. It’s greatest contribution might be to provide a subject the vocabulary of an altered state of consciousness so that, with interesting and constructive drugs, these effects will be familiar, and thus not distractions.”