Summary
5F-PB-22 (1-pentyfluoro-1H-indole-3-carboxylic acid 8-quinolinyl ester also known as 5F-QUPIC) is a synthetic cannabinoid and agonist of the cannabinoid receptors which produces predominantly sedating subjective effects somewhat similar to that of cannabis. There is very little information regarding the pharmacology of this compound within the scientific literature. Despite this, however, it has been sold as a grey area research chemical through online vendors.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 1-3mg | 3-5mg | 5-8mg | 8mg+ |
| Smoked | 1-3mg | 3-5mg | 5-8mg | 8mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | After Effects | Total |
|---|---|---|---|---|---|
| Oral | 5-10 min | 60-90 min | 0 min | 30-60 min | 120-0 min |
| Smoked | 0 min | 0 min | 0 min | 0 min | 0 min |
Tolerance
Build-up
develops over weeks of regular use via CB1 receptor downregulation
Reset
2–4 weeks for most users; heavy users may need longer
Effects
Positive
- Pain relief
- Stimulation
Negative
- Increased heart rate
- Insomnia
- Pupil dilation
- Nausea
- Spontaneous bodily sensations
- Vasodilation
- Sedation
- Decreased appetite
Positive
- Thought connectivity
- Mindfulness
- Conceptual thinking
- Cognitive euphoria
- Immersion intensification
Negative
- Anxiety
- Paranoia
- Thought deceleration
- Dream suppression
- Motor control loss
- Psychosis
- Emotion intensification
Positive
- Color enhancement
- Increased music appreciation
- Auditory acuity enhancement
Negative
- Dehydration
- Visual acuity suppression
- Light sensitivity
- Changes in felt gravity
- Perception of bodily heaviness
- Appetite intensification
- Dulled perception