5F-PB-22 Stats & Data
NPS DataHub
MW376.43
FormulaC23H21FN2O2
IUPAC1-(5-fluoropentyl)-1H-indole-3-carboxylic acid 8-quinolinyl ester
SMILES
FCCCCCn1cc(C(=O)Oc2cccc3cccnc23)c2ccccc12InChIKey
MBOCMBFDYVSGLJ-UHFFFAOYSA-N
Chemical Class
Cannabinoid
Subjective Effects
Physical
- Spontaneous tactile sensations: The body high of 5F-PB-22 can be described as a warm and soft pleasurable, all-encompassing tingling sensation that spreads over the body. It maintains a consistent presence that quickly rises with the onset and hits its limit once the peak has been reached before immediately dissipating.
- Sedation: Generally, the effects on the user's energy levels are very sedating. This encourages one to relax, lie down, and (at higher doses) fall asleep. It produces strong sedative effects that can be described as on par with JWH-018 and more sedating when compared to THC, JWH-073, THJ-018, AM-2201, or 5F-UR-144 but less than that of 5F-AKB-48.
- Motor control loss: This substance causes a partial to moderate suppression of motor control which intensifies proportional to dose, but rarely results in a complete inability to walk and perform basic movements.
- Appetite enhancement: As with many other cannabinoids, 5F-PB-22 causes an increase in appetite, known colloquially as "the munchies" in popular American and United Kingdom culture. Clinical studies and survey data have found that cannabis increases food enjoyment and interest in food. This is thought to be due to the way in which endocannabinoids in the hypothalamus activate cannabinoid receptors that are responsible for maintaining food intake.
- Dehydration: This is known colloquially as "cotton mouth" in popular American and United Kingdom culture.
- Vasodilation: Cannabinoids appear to decrease blood pressure by dilating the blood vessels and increasing blood flow throughout the body. The arteries in the eyeball expand from the decreased blood pressure and the heart rate increases to compensate for the reduction in pressure.
- Pain relief: Cannabinoids have been clinically demonstrated to provide pain relief via agonism of cannabinoid receptors CB1 and CB2, which extends to synthetic cannabinoid receptor agonists.
- Perception of increased weight or Perception of decreased weight
- Changes in gravity: 5F-PB-22, like other cannabinoids, is capable of causing vertigo with which the environment appears to be spinning or oscillating. At moderate doses, it can spontaneously induce the sensation of falling, which can be overwhelming and uncomfortable. The propensity of this is greatly reduced and eliminated in proportion to tolerance.
- Increased heart rate
Cognitive
- Current mind state enhancement: The most prominent cognitive component of cannabinoids is the way in which they enhance the emotions one is already feeling proportional to dose. This can result in euphoria, extreme laughter, and increased immersion within tasks and activities, or it can result in anxiety and paranoia depending on the user's current mind state.
- Euphoria: This can be considered very prominent in comparison to THJ-018, AM-2201, and 5F-UR-144 but less intense in comparison to JWH-073.
- Thought connectivity: This can attribute to fluid, more abstract thinking in comparison to linear thought.
- Anxiety: Subjectively, 5F-PB-22 is less anxiogenic and stimulating than Δ9-THC, THJ-018, AM-2201, or 5F-UR-144 but more so than JWH-073 or JWH-018.
- Paranoia: All cannabinoids are capable of inducing paranoia at high doses or with chronic administration.
- Thought deceleration
- Conceptual thinking
- Mindfulness
- Information processing suppression
- Dream suppression
- Immersion enhancement
Sensory
Auditory
- Enhancements
Visual
- Colour enhancement
- Acuity suppression
- Geometry: As reported with other cannabinoids, 5F-PB-22 can produce closed eye visuals at moderate doses, which can escalate into visual distortions such as a ripples in the field of vision upon continuous administration. Within users who also regularly use psychedelics, it is capable of inducing these consistently in a visual style which seems to be an averaged out depiction of all the psychedelics one has used within the past. These rarely extend beyond level 4 geometry and are considered to be mild, fine, small and zoomed out but brighter and better defined than the geometry experienced with cannabis. They are not as defined as other synthetic cannabinoids such as JWH-018 or JWH-073.
Forked from Subjective Effect Documentation work by Josie Kins, September 2015. Via dose.wiki (CC0).
Toxicity
PsychonautWikiThe toxicity and long-term health effects of recreational 5F-PB-22 use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because 5F-PB-22 has very little history of human usage. Informal experiments have shown that overdose will cause physical discomfort including heart palpitations, vertigo and sedation at much lower than dangerous doses, usually causing the user to suffer large amounts of anxiety or to fall asleep. There have been many hospital reports involving 5F-PB-22, as well as cases of post-mortem analysis involving 5F-PB-22. Five deaths have been associated with the use of 5F-PB-22 in the United States.
Tolerance & Pharmacokinetics
drugs.wikiTolerance Decay
Full tolerance
3d
Half tolerance
21d
Baseline
~28d
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.