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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    6-APDB

    Aliases: Ema-3, 4-desoxy-mda

    Psychedelic Stimulant Empathogen Research-chemical

    Summary TheDrug.Wiki TripSit PsychonautWiki

    6-APDB (also known as 6-(2-aminopropyl)-2,3-dihydrobenzofuran or 4-Desoxy-MDA) is a stimulant and entactogenic research chemical of the phenethylamine and benzofuran classes. It is a closely related synthetic analogue of MDA and 6-APB and broadly shares the characteristics of serotonin-selective triple monoamine releasers and reuptake inhibitors associated with other entactogenic or empathogenic compounds. 6-APDB was first synthesized and studied along with 5-APDB in 1993 by David E.

    Dose Information TheDrug.Wiki TripSit PsychonautWiki

    ROA Light Common Strong Heavy
    Oral 30-70mg 70-100mg 100-130mg 130mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit PsychonautWiki

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 30-60 min 30-60 min 2-3 hrs 2-3 hrs 24-24 hrs 7-9 hrs

    Effect Profile

    2 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 6.1
    Strong 6/10

    Strong visuals and auditory effects with mild body load, low headspace

    Visual Intensity ×3
    10
    colour enhancement autonomous entities tracers pattern recognition enhancement after images acuity enhancement
    Headspace Depth ×3
    1
    time distortion
    Auditory Effects ×1
    10
    auditory enhancement auditory distortion auditory hallucination
    ⚠ Body Load / Somatic Effects ×1
    4
    teeth grinding increased heart rate sweating
    Empathogen 8.7
    Intense+ 9/10

    Strong euphoria, sensory enhancement, and empathy with moderate stimulation

    Empathy / Social Openness ×3
    8
    empathy, love, and sociability enhancement empathy, affection and sociability enhancement increased sociability
    Euphoria / Mood Elevation ×2
    10
    physical euphoria cognitive euphoria euphoria mood lift
    Stimulation ×1
    7
    stimulation wakefulness teeth grinding increased heart rate
    Sensory Enhancement ×1
    10
    tactile enhancement colour enhancement acuity enhancement increased libido
    Stimulant 7.0
    Strong+ 7/10

    Strong euphoria and anxiety/jitters with moderate stimulation and focus

    Stimulation / Energy ×3
    7
    stimulation stamina enhancement wakefulness
    Euphoria / Mood Lift ×2
    10
    physical euphoria cognitive euphoria euphoria mood lift motivation enhancement
    Focus / Productivity ×2
    7
    focus enhancement motivation enhancement thought acceleration
    ⚠ Anxiety / Jitters ×1
    9
    anxiety increased heart rate teeth grinding sweating
    Based on reports from:
    Bluelight Big & Dandy Thread Erowid Experience Reports PsychonautWiki 6-APDB
    View methodology →

    Tolerance

    Build-up develops over days to weeks of regular use
    Reset 3–7 days for acute; 1–3 weeks for full reset

    Tolerance Decay

    Full tolerance 1d Half tolerance 12d Baseline ~21d

    Effects TheDrug.Wiki TripSit PsychonautWiki

    Positive
    • Physical euphoria
    • Stamina enhancement
    • Creativity enhancement
    • Increased energy/alertness
    • Stimulation
    Negative
    • Pupil dilation
    • Increased heart rate
    • Increased blood pressure
    • Increased perspiration
    • Teeth grinding
    • Nystagmus
    • Temporary erectile dysfunction
    • Weight loss
    • Sweating
    Neutral
    • Stimulation and sedation
    • Increased bodily temperature
    • Difficulty urinating
    • Decreased need for sleep
    • Decreased appetite
    • Distrubed sleep patterns
    • Bruxia
    • Spontaneous bodily sensations
    • Sedation
    • Stamina intensification
    Positive
    • Empathy, love, and sociability enhancement
    • Cognitive euphoria
    • Anxiety suppression
    • Focus enhancement
    • Immersion enhancement
    • Mindfulness
    • Motivation enhancement
    • Wakefulness
    • Unity and interconnectedness
    • Euphoria
    • Increased sociability
    • Mood lift
    • Empathy, affection and sociability enhancement
    • Dream potentiation
    • Immersion intensification
    Negative
    • Compulsive redosing
    • Agressiveness
    • Depression
    • Anxiety
    • Irritability
    • Thought deceleration
    • Brain zaps
    • Cognitive fatigue
    • Motivation depression
    Neutral
    • Time distortion
    • Thought acceleration
    • Peripheral information misinterpretation
    • Excessive talking
    • Moodiness
    • Existential self-realization
    • Focus intensification
    Positive
    • Increased music appreciation
    • Tactile enhancement
    • Bodily control enhancement
    • Perception of bodily lightness
    • Increased libido
    • Auditory enhancement
    • Colour enhancement
    • Pattern recognition enhancement
    • Acuity enhancement
    • Tracers
    • Color enhancement
    • Auditory acuity enhancement
    Negative
    • Dehydration
    • Appetite suppression
    Neutral
    • After images
    • Autonomous entities
    • Increase sexuality
    • Visual and audiotory hallucinations itchiness
    • Auditory hallucination
    • Auditory distortion
    • Vibrating vision
    • Symmetrical texture repetition
    • External hallucination
    • Internal hallucination
    • Autonomous entity
    • Perspective hallucination
    • Tactile intensification

    Combinations TripSit

    6-APDB's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 TripSit 📖 Bluelight 📖 PsychonautWiki