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    Disclaimer
    ๐Ÿงช This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.
    โš  Opioids carry significant risk of respiratory depression, physical dependence, and fatal overdose. Never combine with other depressants.

    6-MAM Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 2 corroborating sources
    • 3 ROAs with full dose ladders
    • duration data present
    • 19 combo interactions documented
    • PubChem toxicity data
    • classified Research-chemical
    • dose data not in PW/TripSit (unverifiable)

    Aliases: 6-am, 6-acetylmorphine

    Depressant Research-chemical Opioid

    Summary TheDrug.Wiki

    6-MAM is the primary active metabolite of heroin and is responsible for heroin's characteristic rapid rush and intense euphoria. It crosses the blood-brain barrier more efficiently than morphine and appears in brain tissue at higher concentrations than heroin itself. Rarely sold in pure form; most encounters arise from black-tar heroin or deliberate synthesis.

    Dose Information TheDrug.Wiki

    ROA Light Common Strong Heavy
    Intravenous 3-5mg 5-10mg 10-15mg 15mg+
    Insufflated 5-15mg 15-25mg 25-35mg 35mg+
    Smoked 2-5mg 5-15mg 15-25mg 25mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki

    ROA Onset Peak Offset After Effects Total
    Intravenous 5-10 min 5-30 min 1-2 hrs 30-60 min 2-4 hrs
    Insufflated 5-10 min 5-30 min 1-2 hrs 30-60 min 2-4 hrs
    Smoked - 5-30 min 1-2 hrs 30-60 min 2-4 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Opioid 7.9
    Intense 8/10

    Strong euphoria and pain relief with moderate itching/nausea and sedation

    Euphoria / Warmth ×3
    10
    physical euphoria cognitive euphoria euphoria mood lift
    Analgesia ×2
    8
    pain relief analgesia
    Sedation / Relaxation ×1
    6
    sedation muscle relaxation dream potentiation
    ⚠ Itching / Nausea ×1
    7
    nausea constipation dry mouth
    Based on reports from:
    Erowid Experience Reports PsychonautWiki 6-MAM
    View methodology →

    Tolerance

    Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
    Reset 7โ€“14 days for partial reset; full reset may take weeks โ€” tolerance loss greatly increases overdose risk

    Tolerance Decay

    Full tolerance 3d Half tolerance 7d Baseline ~10d

    Rapid tolerance accrual with consecutive days of heavy dosing is widely reported. Clinically, overdose risk increases sharply after even brief abstinence due to lost tolerance; take-home naloxone and not using alone are key HR measures.

    Cross-Tolerances

    all ฮผ-opioid agonists
    80%

    Effects TheDrug.Wiki

    Positive
    • Physical euphoria
    • Pain relief
    • Muscle relaxation
    • Analgesia
    Negative
    • Respiratory depression
    • Nausea
    • Dry Mouth
    Neutral
    • Sedation
    • Itchiness
    • Pupil constriction
    Positive
    • Cognitive euphoria
    • Anxiety suppression
    • Euphoria
    • Mood lift
    • Dream potentiation
    • Cognitive Euphoria
    Negative
    • Thought deceleration
    • Compulsive redosing
    • Constipation
    • Dizziness
    Negative
    • Appetite suppression
    • Double vision
    • Decreased libido
    • Decreased Libido
    • Appetite Suppression
    • Orgasm suppression
    • Cognitive dysphoria
    Neutral
    • Dulled perception
    • Internal hallucination
    • Internal hallucinations

    Combinations TripSit

    Cross-Check 6-MAM with another substance

    6-MAM's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    ๐Ÿ“˜ Experience Reports ๐Ÿ“– TheDrug.Wiki ๐Ÿ“– PsychonautWiki