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    Disclaimer
    ๐Ÿงช This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.
    โš  Opioids carry significant risk of respiratory depression, physical dependence, and fatal overdose. Never combine with other depressants.

    6-MAM Well-documented
    Well-documented
    Multiple authoritative sources agree on dosing and effects.
    • 3 corroborating sources
    • 3 ROAs with full dose ladders
    • duration data present
    • 19 combo interactions documented
    • toxicity data (PsychonautWiki)
    • classified Research-chemical
    • dose data not in PW/TripSit (unverifiable)

    Aliases: 6-am, 6-acetylmorphine

    Depressant Research-chemical Opioid

    Summary dose.wiki

    6-MAM is the primary active metabolite of heroin and is responsible for heroin's characteristic rapid rush and intense euphoria. It crosses the blood-brain barrier more efficiently than morphine and appears in brain tissue at higher concentrations than heroin itself. Rarely sold in pure form; most encounters arise from black-tar heroin or deliberate synthesis.

    Dose Information dose.wiki Drugs.Wiki

    Dose basis. The dose figures on this page come from clinical practice, where this drug is given by trained staff who are titrating to effect with airway support and monitoring immediately available. They are not a self-administration guide, and the margin they assume does not exist outside that setting. Assume full respiratory depression, keep naloxone to hand, never dose alone, and never combine with benzodiazepines, alcohol or other depressants.

    ROA Light Common Strong Heavy
    Intravenous 3-5mg 5-10mg 10-15mg 15mg+
    Insufflated 5-15mg 15-25mg 25-35mg 35mg+
    Smoked 2-5mg 5-15mg 15-25mg 25mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects dose.wiki Drugs.Wiki

    ROA Onset Comeup Peak Offset After Effects Total
    Intravenous <1-1 min 1-2 min 5-30 min 1-2 hrs 30-60 min 1.1-2.55 hrs
    Insufflated 1-5 min 5-10 min 10-45 min 1-2 hrs 30-60 min 1.27-3 hrs
    Smoked <1-2 min 1-3 min 5-30 min 1-2 hrs 30-60 min 1.1-2.58 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Opioid 7.9
    Intense 8/10

    Strong euphoria and pain relief with moderate itching/nausea and sedation

    Euphoria / Warmth ×3
    10
    physical euphoria cognitive euphoria euphoria mood lift
    Analgesia ×2
    8
    pain relief analgesia
    Sedation / Relaxation ×1
    6
    sedation muscle relaxation dream potentiation
    ⚠ Itching / Nausea ×1
    7
    nausea constipation dry mouth
    View methodology →

    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track 6-MAM there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "6-MAM (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    6-MAM
    Unit
    mg
    Description 
    6-MAM
Source: SubstanceSearch (substancesearch.com)

Intravenous dose (mg): threshold 2 ยท light 3-5 ยท common 5-10 ยท strong 10-15 ยท heavy 15+
Insufflated dose (mg): threshold 5 ยท light 5-15 ยท common 15-25 ยท strong 25-35 ยท heavy 35+
Smoked dose (mg): threshold 2 ยท light 2-5 ยท common 5-15 ยท strong 15-25 ยท heavy 25+

Intravenous duration: onset <1-1m ยท come-up 1-2m ยท peak 5-30m ยท offset 1-2h ยท total 1.1-2.55h ยท after-effects 0.5-1h
Insufflated duration: onset 1-5m ยท come-up 5-10m ยท peak 10-45m ยท offset 1-2h ยท total 1.27-3h ยท after-effects 0.5-1h
Smoked duration: onset <1-2m ยท come-up 1-3m ยท peak 5-30m ยท offset 1-2h ยท total 1.1-2.58h ยท after-effects 0.5-1h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 7.5 mg (Intravenous).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.

    Tolerance

    Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
    Reset 7โ€“14 days for partial reset; full reset may take weeks โ€” tolerance loss greatly increases overdose risk

    Tolerance Decay

    Full tolerance 3d Half tolerance 7d Baseline ~10d

    Rapid tolerance accrual with consecutive days of heavy dosing is widely reported. Clinically, overdose risk increases sharply after even brief abstinence due to lost tolerance; take-home naloxone and not using alone are key HR measures.

    Cross-Tolerances

    all ฮผ-opioid agonists
    80%

    Effects dose.wiki

    Positive
    • Physical euphoria
    • Pain relief
    • Muscle relaxation
    • Analgesia
    Negative
    • Respiratory depression
    • Nausea
    • Dry Mouth
    Neutral
    • Sedation
    • Itchiness
    • Pupil constriction
    Positive
    • Cognitive euphoria
    • Anxiety suppression
    • Euphoria
    • Mood lift
    • Dream potentiation
    Negative
    • Thought deceleration
    • Compulsive redosing
    • Constipation
    • Dizziness
    Negative
    • Appetite suppression
    • Double vision
    • Decreased libido
    • Orgasm suppression
    • Cognitive dysphoria
    Neutral
    • Dulled perception
    • Internal hallucination
    • Internal hallucinations

    Combinations

    Cross-Check 6-MAM with another substance

    6-MAM's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    ๐Ÿ“˜ Experience Reports ๐Ÿ“– dose.wiki ๐Ÿ“– PsychonautWiki