7-OH
Aliases: 7-oh-mit, 7-hydroxy mitragynine, Mitragynine hydroxyindolenine, 9-methoxycorynantheidine hydroxyindolenine
Summary
Present only at โ0.6 % in kratom leaf, bulk 7-OH sold today is semisynthetic. Community assays reveal large potency discrepancies between commercial tablets; verified pure material produces pronounced opioid effects at single-digit milligram doses. Users describe hydromorphone-like euphoria, rapidly waning after โ2 h, driving frequent redosing.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 1-3mg | 3-5mg | 5-10mg | 10mg+ |
| Sublingual | 0.8-2mg | 2-4mg | 4-8mg | 8mg+ |
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset |
|---|---|---|---|
| Oral | 5-15 min | 30-90 min | 1-3 hrs |
| Sublingual | 5-15 min | 30-90 min | 1-3 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong euphoria and itching/nausea with mild sedation
Tolerance
Tolerance Decay
Patterns are inferred from preclinical abuse-liability findings and extensive user reports of rapid escalation and cross-tolerance with traditional opioids. Decay estimates reflect typical opioid tolerance washout over 1โ2 weeks; high individual variability is expected. Overall data quality is anecdotal with support from animal studies.
Cross-Tolerances
Effects
- Physical Euphoria
- Stimulation
- Physical euphoria
- Itching
- Nausea
- Respiratory Depression
- Rapid Tolerance
- Pupil dilation
- Sedation
- Pupil Constriction
- Dream Potentiation
- Reduced anxiety
- Cognitive euphoria
- Euphoria
- Wakefulness
- Anxiety
- Dizziness
- Confusion
- Compulsive redosing
- Time distortion
- Auditory enhancement
- Light sensitivity
- Appetite suppression
- Dulled perception
- Drifting
- Internal hallucination
- Auditory hallucinations
- Perception of increased weight
- Internal hallucinations
- Auditory distortion