10mg (ish) roughly half of an 18mg pill consumed orally about 1 hour ago. Person is feeling classic opioid comeup, warmth, and some consistent pains have been relieved to an amnt they are satisfied worth.
7-OH
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 29 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 29 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Aliases: 7-oh-mit, 7-hydroxy mitragynine, Mitragynine hydroxyindolenine, 9-methoxycorynantheidine hydroxyindolenine
Summary
Present only at โ0.6 % in kratom leaf, bulk 7-OH sold today is semisynthetic. Community assays reveal large potency discrepancies between commercial tablets; verified pure material produces pronounced opioid effects at single-digit milligram doses. Users describe hydromorphone-like euphoria, rapidly waning after โ2 h, driving frequent redosing.
Dose Information
Dose basis. The dose figures on this page are not clinical data. They are aggregated from community reports by a secondary source whose own notes state there is no human pharmacokinetic study behind them, and our internal audit flags this substance's dosing as unverifiable. Treat them as a rough orientation, not a safe range. Assume full respiratory depression, keep naloxone to hand, never dose alone, and never combine with benzodiazepines, alcohol or other depressants.
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 1-3mg | 3-5mg | 5-10mg | 10mg+ |
| Sublingual | 0.8-2mg | 2-4mg | 4-8mg | 8mg+ |
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Oral | 5-15 min | 30-90 min | 1-3 hrs | 1.58-4.75 hrs |
| Sublingual | 5-15 min | 30-90 min | 1-3 hrs | 1.58-4.75 hrs |
Effect Profile
Scores (0–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Opioid
4.7
Moderate+
5/10
Strong euphoria with strong itching/nausea, mild sedation
Euphoria / Warmth
×3
9
physical euphoria
cognitive euphoria
euphoria
Analgesia
×2
0
Sedation / Relaxation
×1
4
sedation
dream potentiation
Itching / Nausea
×1
8
itching
nausea
Tolerance
Build-up
develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
Reset
Falls quickly once you stop, at a rate you can't judge. After any break, treat your tolerance as gone.
No tolerance chart. Our decay curves for opioids were estimates, and a curve can make tolerance look longer-lasting than it is, which is the dangerous direction.
Opioid tolerance drops fast when you stop, and even a few days off can be enough, so a dose that used to be normal can now stop your breathing. Overdose deaths rise sharply after prison, detox or leaving treatment, and tolerance also falls during a hospital stay. After any break, start with a much smaller amount, try a test dose first, don't use alone, and keep naloxone within reach. Alcohol, benzodiazepines, gabapentinoids and other sedatives make an opioid overdose much more likely.
Sources: FRANK: heroin ยท National Harm Reduction Coalition ยท WHO: opioid overdose ยท Merrall et al. 2010 ยท Binswanger et al. 2007 ยท Strang et al. 2003 ยท FDA 2019: gabapentinoids and breathing
Cross-Tolerances
classic ฮผ-opioid agonists (morphine, oxycodone)
other kratom-alkaloid extracts
Effects
Effect glossary — · full glossary
Positive
Negative
Positive
Negative
Positive
Negative
Combinations
Cross-Check 7-OH with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, Bluelight, and Dose.wiki. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.
Bluelight 1 thread 1 neutral visit
7-OH's nerd page
Pharmacology, chemical data, effect profiles, and more
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Helpful Links
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track 7-OH there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
⬇ Download import file
Import this file as custom substances
and you get "7-OH (Substance Search)" with every
route's full dose ladder and timeline, no typing. Works on iOS and
Android (v15+); the format is confirmed by the app's
developer. The manual values below work for older
versions.
Name
7-OH
Unit
mg
Description
7-OH Source: SubstanceSearch (substancesearch.com) Oral dose (mg): threshold 0.5-1 ยท light 1-3 ยท common 3-5 ยท strong 5-10 ยท heavy 10+ Sublingual dose (mg): threshold 0.3-0.8 ยท light 0.8-2 ยท common 2-4 ยท strong 4-8 ยท heavy 8+ Oral duration: onset 5-15m ยท peak 0.5-1.5h ยท offset 1-3h ยท total 1.58-4.75h ยท after-effects 2-8h Sublingual duration: onset 5-15m ยท peak 0.5-1.5h ยท offset 1-3h ยท total 1.58-4.75h ยท after-effects 2-8h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 4 mg (Oral).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
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