10mg (ish) roughly half of an 18mg pill consumed orally about 1 hour ago. Person is feeling classic opioid comeup, warmth, and some consistent pains have been relieved to an amnt they are satisfied worth.
7-OH
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 19 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 19 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Aliases: 7-oh-mit, 7-hydroxy mitragynine, Mitragynine hydroxyindolenine, 9-methoxycorynantheidine hydroxyindolenine
Summary
Present only at โ0.6 % in kratom leaf, bulk 7-OH sold today is semisynthetic. Community assays reveal large potency discrepancies between commercial tablets; verified pure material produces pronounced opioid effects at single-digit milligram doses. Users describe hydromorphone-like euphoria, rapidly waning after โ2 h, driving frequent redosing.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 1-3mg | 3-5mg | 5-10mg | 10mg+ |
| Sublingual | 0.8-2mg | 2-4mg | 4-8mg | 8mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset |
|---|---|---|---|
| Oral | 5-15 min | 30-90 min | 1-3 hrs |
| Sublingual | 5-15 min | 30-90 min | 1-3 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Opioid
5.1
Moderate+
5/10
Strong euphoria and itching/nausea with mild sedation
Euphoria / Warmth
×3
10
physical euphoria
cognitive euphoria
euphoria
Analgesia
×2
0
Sedation / Relaxation
×1
4
sedation
dream potentiation
Itching / Nausea
×1
8
itching
nausea
Based on reports from:
Tolerance
Build-up
develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
Reset
7โ14 days for partial reset; full reset may take weeks โ tolerance loss greatly increases overdose risk
Tolerance Decay
Full tolerance
3d
Half tolerance
5d
Baseline
~35d
Acute tolerance: develops within a single session โ the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Patterns are inferred from preclinical abuse-liability findings and extensive user reports of rapid escalation and cross-tolerance with traditional opioids. Decay estimates reflect typical opioid tolerance washout over 1โ2 weeks; high individual variability is expected. Overall data quality is anecdotal with support from animal studies.
Cross-Tolerances
Effects
Positive
- Physical Euphoria
- Stimulation
- Physical euphoria
Negative
- Itching
- Nausea
- Respiratory Depression
- Rapid Tolerance
- Pupil dilation
- Sedation
- Pupil Constriction
Positive
- Dream Potentiation
- Reduced anxiety
- Cognitive euphoria
- Euphoria
- Wakefulness
Negative
- Anxiety
- Dizziness
- Confusion
- Compulsive redosing
- Time distortion
Positive
- Auditory enhancement
Negative
- Light sensitivity
- Appetite suppression
- Dulled perception
- Drifting
- Internal hallucination
- Auditory hallucinations
- Perception of increased weight
- Internal hallucinations
- Auditory distortion
Combinations
Cross-Check 7-OH with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.
Bluelight 1 thread 1 neutral visit
7-OH's nerd page
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