7-OH
Aliases: 7-oh-mit, 7-hydroxy mitragynine, Mitragynine hydroxyindolenine, 9-methoxycorynantheidine hydroxyindolenine
Categories
Summary
Present only at ≈0.6 % in kratom leaf, bulk 7-OH sold today is semisynthetic. Community assays reveal large potency discrepancies between commercial tablets; verified pure material produces pronounced opioid effects at single-digit milligram doses. Users describe hydromorphone-like euphoria, rapidly waning after ≈2 h, driving frequent redosing. Withdrawal emerges after 3–5 days of daily use and is reportedly more dysphoric than kratom leaf alone. Harm-reduction advice includes starting ≤1 mg, spacing doses ≥6 h, combining with plain leaf rather than escalating 7-OH, and securing naloxone.
Dose Information
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | After Effects |
|---|---|---|---|---|
| Oral (Tablets / Capsules; Dissolved Powder) | 5-15 min | 30-90 min | 1-3 hrs | 2-8 hrs |
| Sublingual / Buccal | 5-15 min | 30-90 min | 1-3 hrs | 2-8 hrs |
Tolerance
Build-up
develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
Reset
7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk
Effects
Positive
- Physical Euphoria
- Stimulation
- Physical euphoria
Negative
- Itching
- Nausea
- Respiratory Depression
- Rapid Tolerance
- Pupil dilation
- Sedation
- Pupil Constriction
Positive
- Dream Potentiation
- Reduced anxiety
- Cognitive euphoria
- Euphoria
- Wakefulness
Negative
- Anxiety
- Dizziness
- Confusion
- Compulsive redosing
- Time distortion
Positive
- Auditory enhancement
Negative
- Light sensitivity
- Appetite suppression
- Dulled perception
- Drifting
- Internal hallucination
- Auditory hallucinations
- Perception of increased weight
- Internal hallucinations
- Auditory distortion