10mg (ish) roughly half of an 18mg pill consumed orally about 1 hour ago. Person is feeling classic opioid comeup, warmth, and some consistent pains have been relieved to an amnt they are satisfied worth.
7-OH
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 19 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 19 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Aliases: 7-oh-mit, 7-hydroxy mitragynine, Mitragynine hydroxyindolenine, 9-methoxycorynantheidine hydroxyindolenine
Summary
Present only at โ0.6 % in kratom leaf, bulk 7-OH sold today is semisynthetic. Community assays reveal large potency discrepancies between commercial tablets; verified pure material produces pronounced opioid effects at single-digit milligram doses. Users describe hydromorphone-like euphoria, rapidly waning after โ2 h, driving frequent redosing.
Dose Information
Dose basis. The dose figures on this page are not clinical data. They are aggregated from community reports by a secondary source whose own notes state there is no human pharmacokinetic study behind them, and our internal audit flags this substance's dosing as unverifiable. Treat them as a rough orientation, not a safe range. Assume full respiratory depression, keep naloxone to hand, never dose alone, and never combine with benzodiazepines, alcohol or other depressants.
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 1-3mg | 3-5mg | 5-10mg | 10mg+ |
| Sublingual | 0.8-2mg | 2-4mg | 4-8mg | 8mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Oral | 5-15 min | 30-90 min | 1-3 hrs | 1.58-4.75 hrs |
| Sublingual | 5-15 min | 30-90 min | 1-3 hrs | 1.58-4.75 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Opioid
4.7
Moderate+
5/10
Strong euphoria and itching/nausea with mild sedation
Euphoria / Warmth
×3
9
physical euphoria
cognitive euphoria
euphoria
Analgesia
×2
0
Sedation / Relaxation
×1
4
sedation
dream potentiation
Itching / Nausea
×1
8
itching
nausea
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track 7-OH there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
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Import this file as custom substances
and you get "7-OH (Substance Search)" with every
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Android (v15+); the format is confirmed by the app's
developer. The manual values below work for older
versions.
Name
7-OH
Unit
mg
Description
7-OH Source: SubstanceSearch (substancesearch.com) Oral dose (mg): threshold 0.5-1 ยท light 1-3 ยท common 3-5 ยท strong 5-10 ยท heavy 10+ Sublingual dose (mg): threshold 0.3-0.8 ยท light 0.8-2 ยท common 2-4 ยท strong 4-8 ยท heavy 8+ Oral duration: onset 5-15m ยท peak 0.5-1.5h ยท offset 1-3h ยท total 1.58-4.75h ยท after-effects 2-8h Sublingual duration: onset 5-15m ยท peak 0.5-1.5h ยท offset 1-3h ยท total 1.58-4.75h ยท after-effects 2-8h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 4 mg (Oral).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Build-up
develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
Reset
7โ14 days for partial reset; full reset may take weeks โ tolerance loss greatly increases overdose risk
Tolerance Decay
Full tolerance
3d
Half tolerance
5d
Baseline
~35d
Acute tolerance: develops within a single session โ the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Patterns are inferred from preclinical abuse-liability findings and extensive user reports of rapid escalation and cross-tolerance with traditional opioids. Decay estimates reflect typical opioid tolerance washout over 1โ2 weeks; high individual variability is expected. Overall data quality is anecdotal with support from animal studies.
Cross-Tolerances
Effects
Positive
- Physical Euphoria
- Stimulation
Negative
- Itching
- Nausea
- Respiratory Depression
- Rapid Tolerance
- Sedation
- Pupil Constriction
Positive
- Dream Potentiation
- Reduced anxiety
- Cognitive euphoria
- Euphoria
- Wakefulness
Negative
- Anxiety
- Dizziness
- Confusion
- Compulsive redosing
- Time distortion
Positive
- Auditory enhancement
Negative
- Light sensitivity
- Appetite suppression
- Dulled perception
- Drifting
- Internal hallucination
- Auditory hallucinations
- Perception of increased weight
- Internal hallucinations
- Auditory distortion
Combinations
Cross-Check 7-OH with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.
Bluelight 1 thread 1 neutral visit
7-OH's nerd page
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