Summary
Ξ±-PPP is the three-carbon homologue in the pyrrolidinophenone series (shorter alkyl chain than Ξ±-PVP and Ξ±-PBP). It acts as a potent DAT and NET inhibitor with negligible SERT activity, but uniquely also functions as a partial norepinephrine releasing agent and 5-HT2A antagonistβproperties not shared by Ξ±-PVP. This 5-HT2A antagonism may contribute to its reportedly lower euphoria and reduced popularity compared to Ξ±-PVP. Community reports describe 20-40 mg insufflated or 30-60 mg oral as producing 4-6 hours of focused, relatively non-euphoric stimulation with social facilitation. Higher doses (β₯90 mg oral, β₯70 mg intranasal) increase peripheral vasoconstriction, bruxism, and tremor without proportional mood elevation.
Dose Information
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects |
|---|---|---|---|---|---|
| Oral | 15-45 min | 20-40 min | 30 min | 1-2 hrs | 2-12 hrs |
| Insufflated | 5-15 min | 10-20 min | 30 min | 1-2 hrs | 2-12 hrs |
| Vaporized | 1-2 min | 3-5 min | 30 min | 1-2 hrs | 2-12 hrs |
| Intravenous | 1 min | 1-3 min | 30 min | 1-2 hrs | 2-12 hrs |
Tolerance
Build-up
develops over days to weeks of regular use
Reset
3β7 days for acute; 1β3 weeks for full reset
Effects
Positive
- Stimulation
Negative
- Vasoconstriction
- Bruxism
- Tachycardia
- Temperature regulation suppression
- Increased heart rate
- Teeth grinding
- Insomnia
- Increased blood pressure
- Increased perspiration
Positive
- Focus enhancement
- Motivation enhancement
- Increased sociability
- Wakefulness
- Euphoria
- Cognitive euphoria
Negative
- Anxiety
- Compulsive redosing
- Paranoia
- Thought acceleration
Positive
- Increased libido
- Tactile enhancement
- Increased music appreciation
Negative
- Appetite suppression
- Light sensitivity
- Dehydration
- Disinhibition
- Appetite Suppression
- Vibrating vision
- Increase sexuality