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    Disclaimer
    ☠ This is a fentanyl analogue active in microgram doses. Accidental overdose can be rapidly fatal. Naloxone should always be on hand.
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    Acetylfentanyl

    Aliases: A-f, Desmethyl fentanyl, Wrongly called china white, acetyl-fentanyl

    Depressant Research-chemical Opioid

    Summary TheDrug.Wiki Erowid TripSit PsychonautWiki

    Acetylfentanyl is a synthetic opioid substance of the anilidopiperidine chemical class that produces analgesic, anxiety suppressing, and euphoric effects when administered. It is a structural analog of fentanyl. Studies have estimated acetylfentanyl to be between five to fifteen times more potent than heroin, eighty times more potent than morphine, and fifteen times less potent than its parent compound, fentanyl.

    Dose Information TheDrug.Wiki TripSit PsychonautWiki

    ROA Light Common Strong Heavy
    Sublingual 5-10mg 10-15mg 15-20mg 20mg+
    Insufflated 5-10mg 10-15mg 15-20mg 20mg+
    Oral 1-3mg 3-5mg 5-7mg 7mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit PsychonautWiki

    ROA Onset Peak Offset After Effects Total
    Sublingual 20-40 min 1-2 hrs 30-90 min 1-4 hrs 1.8-4.2 hrs
    Insufflated 5-15 min 30-90 min 30-60 min 1-3 hrs 1.1-2.8 hrs
    Oral 5-20 min 1-4 hrs - 1-8 hrs 1.1-4.3 hrs

    Effect Profile

    5 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Opioid 8.4
    Intense 8/10

    Strong euphoria and pain relief with moderate sedation, mild itching/nausea

    Euphoria / Warmth ×3
    10
    physical euphoria cognitive euphoria euphoria mood lift
    Analgesia ×2
    8
    pain relief analgesia
    Sedation / Relaxation ×1
    7
    sedation drowsiness dream potentiation
    ⚠ Itching / Nausea ×1
    4
    constipation dry mouth
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Acetylfentanyl
    View methodology →

    Tolerance

    Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
    Reset 7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk

    Tolerance Decay

    Full tolerance 1d Half tolerance 21d Baseline ~35d

    Effects TheDrug.Wiki TripSit PsychonautWiki

    Positive
    • Pain Relief
    • Physical Euphoria
    • Cough Suppression
    • Analgesia
    Negative
    • Respiratory Depression
    • Dry Mouth
    Neutral
    • Sedation
    • Itchiness
    • Pupil Constriction
    • Difficulty Urinating
    • Relaxant
    Positive
    • Cognitive Euphoria
    • Anxiety Suppression
    • Dream Potentiation
    • Euphoria
    • Mood lift
    • Feelings of relaxation
    Negative
    • Constipation
    • Compulsive Redosing
    • Drowsiness
    Neutral
    • Changes in focus
    Negative
    • Decreased Libido
    • Dehydration
    • Double Vision
    • Appetite Suppression
    • Orgasm Suppression
    • Orgasm depression
    • Acuity Suppression
    • Disinhibition
    • Light sensitivity
    Neutral
    • Dulled perception

    Combinations TripSit

    Acetylfentanyl's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

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