ADB-PINACA isomer 2
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 3 corroborating sources
- 3 ROAs with full dose ladders
- duration data present
- 16 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
- 3 corroborating sources
- 3 ROAs with full dose ladders
- duration data present
- 16 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Summary
ADB-PINACA isomer 2 is a positional isomer of Schedule I ADB-PINACA with an isoleucine-derived side chain rather than tert-leucine. Expected to have sub-nanomolar CB1 affinity similar to related compounds (likely Ki < 1 nM), meaning single-milligram doses can cause severe intoxication, catatonia, or seizures. Fatalities and acute kidney injury have been documented with the parent compound and closely related isomers.
Dose Information
Dose basis. Extremely batch- and vendor-dependent; values are based on cross-analog user reports for indazole-3-carboxamide noids. Always use a 0.001 g (1 mg)–readable scale and volumetric dosing to avoid hot spots in herb or oil. Do not eyeball powders. Avoid large, rapid redoses; wait at least 10 minutes between micro-puffs due to steep dose–response and delayed peak. Reports of mislabeled ‘botanical’ or ‘blue lotus’ vape oils containing potent noids (e.g., MDMB‑4en‑PINACA) underline the need for testing and cautious titration. If preparing an e‑liquid, dissolve by weight to a known mg/mL in PG/VG (typical test concentrations 0.2–1.0 mg/mL). Shake thoroughly and label. Use the minimum wattage/temperature that vaporizes the carrier to reduce unknown pyrolysis products. Avoid shared tanks to prevent accidental exposures. (Dose figures and this note are from Drugs.Wiki.)
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Smoked | 0.5-1mg | 1-2mg | 2-3mg | 3mg+ (dangerous) |
| Vaporized | 0.4-0.8mg | 0.8-1.6mg | 1.6-2.5mg | 2.5mg+ |
| Oral | 0.5-1mg | 1-1.5mg | 1.5-2mg | 2mg+ |
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Smoked | 1-2 min | 5-25 min | 45-90 min | 0.84-1.95 hrs |
| Vaporized | 1-2 min | 5-25 min | 45-90 min | 0.84-1.95 hrs |
| Oral | 10-30 min | 30-90 min | 1-2 hrs | 1.67-4 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Mild auditory effects with low visuals, headspace, and body load
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track ADB-PINACA isomer 2 there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
ADB-PINACA isomer 2 Source: SubstanceSearch (substancesearch.com) Smoked dose (mg): threshold 0.5 · light 0.5-1 · common 1-2 · strong 2-3 · heavy 3+ (dangerous) Vaporized dose (mg): threshold 0.4 · light 0.4-0.8 · common 0.8-1.6 · strong 1.6-2.5 · heavy 2.5+ Oral dose (mg): threshold 0.5 · light 0.5-1 · common 1-1.5 · strong 1.5-2 · heavy 2+ Smoked duration: onset 1-2m · peak 5-25m · offset 0.75-1.5h · total 0.84-1.95h · after-effects 4h Vaporized duration: onset 1-2m · peak 5-25m · offset 0.75-1.5h · total 0.84-1.95h · after-effects 4h Oral duration: onset 10-30m · peak 0.5-1.5h · offset 1-2h · total 1.67-4h · after-effects 4h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 1.5 mg (Smoked).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Tolerance accrues rapidly with daily use in this class and often drives compulsive re‑dosing; decay appears slow (weeks) after cessation. Data quality is predominantly anecdotal from user communities and case observations.
Cross-Tolerances
Effects
- Pain relief
- Tachycardia and palpitations
- Dry mouth and eyes
- Nausea
- Seizures
- Dry mouth
- Body heaviness
- Motor incoordination
- Spontaneous bodily sensations
- Sedation
- Euphoria
- Enhanced music appreciation
- Thought connectivity
- Short-term memory suppression
- Anxiety or paranoia
- Compulsive re-dosing
- Anxiety
- Paranoia
- Motor control loss
- Time distortion
- Color enhancement
- Appetite enhancement
- Perception of bodily lightness
- Increased Music Appreciation
- Dehydration
- Closed-eye visuals
- Visual hallucinations
- Visual distortions
- Appetite intensification
- Changes in felt gravity
Combinations
Cross-Check ADB-PINACA isomer 2 with another substanceHelpful Links
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