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    ☠ This substance has been associated with serious adverse events including fatalities. Use extreme caution.
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.
    ⚠ Synthetic cannabinoids are far more potent and unpredictable than natural cannabis. They lack a ceiling effect and have been linked to seizures, psychosis, and death.

    ADB-PINACA isomer 2

    Psychedelic Research-chemical Cannabinoid

    Summary TheDrug.Wiki

    ADB-PINACA isomer 2 is a positional isomer of Schedule I ADB-PINACA with an isoleucine-derived side chain rather than tert-leucine. Expected to have sub-nanomolar CB1 affinity similar to related compounds (likely Ki < 1 nM), meaning single-milligram doses can cause severe intoxication, catatonia, or seizures. Fatalities and acute kidney injury have been documented with the parent compound and closely related isomers.

    Dose Information TheDrug.Wiki

    ROA Light Common Strong Heavy
    Smoked - - - 3+mg(dangerous)+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki

    ROA Onset Peak Offset After Effects
    Smoked 1-2 min 5-25 min 45-90 min 4-4 hrs
    Oral 10-30 min 30-90 min 1-2 hrs 4-4 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 3.8
    Moderate 4/10

    Mild auditory effects with low visuals, headspace, and body load

    Visual Intensity ×3
    3
    color enhancement visual distortions
    Headspace Depth ×3
    3
    thought connectivity time distortion
    Auditory Effects ×1
    4
    enhanced music appreciation
    ⚠ Body Load / Somatic Effects ×1
    2
    nausea
    Based on reports from:
    Erowid Experience Reports PsychonautWiki ADB-PINACA isomer 2
    View methodology →

    Tolerance

    Build-up develops over weeks of regular use via CB1 receptor downregulation
    Reset 2–4 weeks for most users; heavy users may need longer

    Tolerance Decay

    Full tolerance 3d Half tolerance 14d Baseline ~30d

    Tolerance accrues rapidly with daily use in this class and often drives compulsive re‑dosing; decay appears slow (weeks) after cessation. Data quality is predominantly anecdotal from user communities and case observations.

    Cross-Tolerances

    THC
    50%
    Other synthetic cannabinoids
    80%

    Effects TheDrug.Wiki

    Positive
    • Pain relief
    Negative
    • Tachycardia and palpitations
    • Dry mouth and eyes
    • Nausea
    • Seizures
    • Dry mouth
    Neutral
    • Body heaviness
    • Motor incoordination
    • Spontaneous bodily sensations
    • Sedation
    Positive
    • Euphoria
    • Enhanced music appreciation
    • Thought connectivity
    Negative
    • Short-term memory suppression
    • Anxiety or paranoia
    • Compulsive re-dosing
    • Anxiety
    • Paranoia
    • Motor control loss
    Neutral
    • Time distortion
    Positive
    • Color enhancement
    • Appetite enhancement
    • Perception of bodily lightness
    • Increased Music Appreciation
    Negative
    • Dehydration
    Neutral
    • Closed-eye visuals
    • Visual hallucinations
    • Visual distortions
    • Appetite intensification
    • Changes in felt gravity

    Combinations TripSit

    ADB-PINACA isomer 2's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki