Summary
ADB-PINACA isomer 2 is a positional isomer of Schedule I ADB-PINACA with an isoleucine-derived side chain rather than tert-leucine. Expected to have sub-nanomolar CB1 affinity similar to related compounds (likely Ki < 1 nM), meaning single-milligram doses can cause severe intoxication, catatonia, or seizures. Fatalities and acute kidney injury have been documented with the parent compound and closely related isomers. Laboratory detection standards are limited; routine drug screens rarely detect this isomer, so users may test negative while impaired. Using a milligram scale (0.001 g readability) and thoroughly dissolving powder into carrier (PG/VG e-liquid or acetone for herb spraying) is essential for harm reduction.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Smoked | - | - | - | 3+mg(dangerous)+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | After Effects |
|---|---|---|---|---|
| Smoked | 1-2 min | 5-25 min | 45-90 min | 4 hrs |
| Vaporized | 1-2 min | 5-25 min | 45-90 min | 4 hrs |
| Oral | 10-30 min | 30-90 min | 1-2 hrs | 4 hrs |
Tolerance
Build-up
develops over weeks of regular use via CB1 receptor downregulation
Reset
2–4 weeks for most users; heavy users may need longer
Effects
Positive
- Pain relief
Negative
- Tachycardia and palpitations
- Dry mouth and eyes
- Nausea
- Seizures
- Dry mouth
- Body heaviness
- Motor incoordination
- Spontaneous bodily sensations
- Sedation
Positive
- Euphoria
- Enhanced music appreciation
- Thought connectivity
Negative
- Short-term memory suppression
- Anxiety or paranoia
- Compulsive re-dosing
- Anxiety
- Paranoia
- Motor control loss
- Time distortion
Positive
- Color enhancement
- Appetite enhancement
- Perception of bodily lightness
- Increased Music Appreciation
Negative
- Dehydration
- Closed-eye visuals
- Visual hallucinations
- Visual distortions
- Appetite intensification
- Changes in felt gravity