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    This substance has both stimulant and depressant properties, which can mask the effects of each other and increase the risk of overdose or cardiovascular complications.

    THC Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 3 corroborating sources
    • 2 ROAs with full dose ladders
    • duration data present
    • 26 combo interactions documented
    • PubChem toxicity data
    • classified Tentative

    Aliases: Marinol, Cesamet, Syndros, Dronabinol, Δ9--tetrahydrocannabinol, δ9-thc, delta9-tetrahydrocannabinol, delta9-thc, weed, marijuana, dagga, hash, cannabis

    Summary Erowid TripSit

    Dronabinol is a synthetic form of delta-9-THC, the primary active ingredient in Cannabis. It is presecribed as an appetite stimulant and for treating neuropathic pain in the United States. Dronabinol is one of the examples used to point out the inconsistency of the U.S. and U.N. controlled substance rules and definitions because THC both falls under the classifications as "no accepted medical use" and "accepted medical use".

    Dose Information TripSit PsychonautWiki

    ROA Light Common Strong Heavy
    Oral 10-20mg 20-30mg 30-50mg 50mg+
    Smoked (Cannabis Flower) 10-20mg 20-60mg 60-100mg 100mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TripSit PsychonautWiki

    ROA Onset Peak Offset After Effects Total
    Oral 0.5-2 hrs 4-12 hrs 4-6 hrs 1-4 hrs 8.5-20 hrs
    Smoked (Cannabis Flower) 1-10 min 1-4 hrs 3-4 hrs 2-24 hrs 1-4 hrs

    Effect Profile

    94 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Validated against 94 Erowid trip reports
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 6.6
    Strong+ 7/10

    Strong visuals, body load, and auditory effects with mild headspace

    Visual Intensity ×3
    10
    color enhancement drifting brightened colour
    Headspace Depth ×3
    5
    time distortion confusion
    Auditory Effects ×1
    8
    Body Load / Somatic Effects ×1
    10
    nausea vasoconstriction increased heart rate
    Stimulant 6.5
    Strong 6/10

    Strong stimulation, anxiety/jitters, and euphoria with low focus

    Stimulation / Energy ×3
    10
    stimulation wakefulness alertness enhancement
    Euphoria / Mood Lift ×2
    8
    euphoria cognitive euphoria
    Focus / Productivity ×2
    3
    Anxiety / Jitters ×1
    10
    anxiety restlessness increased heart rate vasoconstriction

    Tolerance

    Build-up develops gradually over weeks of daily use; subjective effects diminish before physiological tolerance
    Reset 2–4 weeks for most users; heavy users may need longer (up to 90 days for full CB1 receptor reset)

    Tolerance Decay

    Full tolerance 10d Half tolerance 14d Baseline ~28d

    Based on human imaging and clinical studies showing CB1 down‑regulation with daily use and reversal over days–weeks. Model is approximate and varies with dose, frequency, and route. Data quality: mixed clinical/anecdotal.

    Cross-Tolerances

    Effects Erowid

    Aggregated from 94 Erowid experience reports

    Positive Effects 12

    Anxiety Suppression 47.9% 70%
    Music Enhancement 38.3% 70%
    Stimulation 34.0% 70%
    Color Enhancement 31.9% 70%
    Euphoria 30.9% 70%
    Empathy 25.5% 70%
    Focus Enhancement 24.5% 70%
    Sedation 22.3% 70%
    Tactile Enhancement 17.0% 70%
    Body High 11.7% 70%
    Introspection 8.5% 70%
    Creativity Enhancement 4.3% 70%

    Adverse Effects 13

    Confusion 29.8% 70%
    Nausea 26.6% 70%
    Memory Suppression 8.5% 70%
    Muscle Tension 6.4% 70%
    Motor Impairment 6.4% 70%
    Increased Heart Rate 6.4% 70%
    Jaw Clenching 5.3% 70%
    Headache 4.3% 70%
    Psychosis 4.3% 70%
    Sweating 4.3% 70%
    Seizure 4.3% 70%
    Appetite Suppression 3.2% 70%
    Thought Loops 3.2% 70%

    Combinations TripSit

    Cross-Check THC with another substance

    Trip Reports Effect Index

    Community Trip Reports

    Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.

    Reddit 8 reports 1 positive 4 neutral 3 cautionary visit
    Just passed the peak of an edible cannabis experience positive ▲7 6 comments

    And I’ve got to tell you, idk if mid-trip posting is the vibe in this chamber, but it’s just the most wonderful, beautiful, *important* experience yours truly is flowing with, riding on atm~💕 Here, so idk if any of y’all have ever read Stephen King’s book *Insomnia,* but first of...

    u/CJClementine · 2024-03-16
    What the fuck did i take? neutral ▲21 58 comments

    Had my first trip yesterday and it went horribly wrong. I was sold what i thought were edibles in a weed shop. 20 Bucks for two edibles, so sorta a reasonable price. I decided to take one with a friend of mine. She took one too, and we went to a shopping street for fun.

    u/bqunnie · 2023-03-05
    Accidentally Tripped balls on RSO (Rick Simpson Oil) neutral ▲13 3 comments

    I’ve stopped using cannabis for a little over a month now. It’s been a good tolerance cleanse. I decided I wanted to get something non smokeable but also without any added food coloring or unwanted unwanted ingredients, so I got ahold of some RSO cannabis oil.

    u/Capable-Pair-9994 ★ 2 reports · 2026-01-20
    Intense weed trips neutral ▲9 5 comments

    So this isnt really a trip report but more of a description of a type of trip I doubt many other people have experienced. Sorry for the text wall I think that this is really interesting and something that ive never seen other people experience to this extent so I just wanted to s...

    u/ManoelGomesPsych ★ 2 reports · 2025-12-02
    THC Carts Almost Killed Me cautionary ▲28 83 comments

    I started smoking weed when I was 18 back in 2017. Around that time carts weren’t as common as they are now. I started buying pens and carts later that year after trying a friends. I liked that I could do it at home and in my car and nobody would know.

    u/anonymous · 2024-12-20
    Unspeakable Horrors cautionary ▲23 11 comments

    I have no idea whether a real ego death is possible with weed, but based on the definitions I've read I think I experienced it last night. I've never tried psychedelics but smoke somewhat regularly, maybe 1-2 times a week on average.

    u/sleepystemmy · 2023-02-02
    Erowid 8 reports 3 positive 3 neutral 2 cautionary visit
    Ladies and Gents, He Has Achieved Liftoff... positive exp #116680

    Consciousness, has always been a topic of intrigue, to me; in particular, ways and means of exploring and mapping states of consciousness to ordinary reality. The first reason, I pursue it for personal or spiritual growth. The second reason, practical knowledge in creating an artificially conscious mind i.e.

    DBLR · Cannabis (edible) · 0.5 oral / 0.5 oral / 0.5 oral / 0.5 oral
    Schizophrenic Journey to Heaven, Hell, In-Between and Back positive exp #61636

    March 22, 2007 First, let me begin by telling you a little bit about myself and that the reason I am writing this is to attain closure. I am seventeen years old and I have great parents who are not divorced, I have two wonderful older siblings, I live in sunny California and life is great.

    GSscla · Cannabis · 0.25 g smoked
    My Experiences With Medical Cannabis positive exp #73627

    'There is no progress in art, any more than there is progress in making love. There are simply different ways of doing it.' -Man Ray I realize that there are a ton of cannabis experience reports, but I have not found adequate representation of my experiences. So here goes. I’m a 32 year old male weighing 80 kg.

    OpenedEyes · Cannabis · 1 hit smoked
    Staggering Blindly Through the Chaos neutral exp #15843

    It somewhat started a day before the fourth of July. Raz and I had the idea to hook our computers up over at his house because his parents would be gone. Then we could play Warcraft 3 for all hours of the day. Then, the fourth of July rolled around, and I went to bed around four-thirty.

    Lsded · Cannabis · 3 bowls smoked / oral / inhaled
    The Philosopher's Tool neutral exp #33811

    Sometimes people who have never smoked cannabis ask me why I do it. Some of them are genuinely curious. Others make a point of saying that they have plenty of fun without drugs. Well good for them, and so do I.

    Brainaddict · Cannabis · repeated smoked
    Time Spirals neutral exp #114402

    Marijuana's Time Spirals Dosage: Approximately 3 Grams of alleged "High Grade" plant material rolled into a blunt. Method of Administration: Smoking. Timing of Administration: Attempted to smoke all at once, but in fact smoked it in at LEAST 2 segments, possibly 3.

    River of Phantasia · Cannabis
    Paranoid Schizophrenic For a Day cautionary exp #94624

    FORWARD: I realize this is a very long report and as a result many people may not read it. I am okay with that as I feel that simply having written it down may have given me the peace that I needed. Thank you. This report is written approximately 1 week after the experience.

    Smokey Smoke · Cannabis
    Scribblings of an Infant Psychonaut cautionary exp #69891

    About Me: I am fifteen years old and am enrolled in lots of overachiever high school classes and so on and so on. Nevertheless, I am decidedly lazy and inconsistent, maybe pulling an A plus in one unit and perhaps failing the next.

    Jane · Cannabis · repeated smoked
    Bluelight 8 threads 2 positive 4 neutral 2 cautionary visit
    Cannabis Master Kush Semi Experienced positive

    Okay, so alot of people ask me if I've hallucinated on sweet MJ before, and I always answer the same way. Truth is, yeah, I've hallucinated on weed. And it isn't really about the fact that I hallucinated, as the fact that it's such an amazing and beautiful journey. Both of my friends and I shared such an experience.

    scraped 2026-03-14
    Rolls Cannabis 3 Tabs Experienced Theme Parks Rolling Amazing Terrifying neutral

    Rolls & Cannabis (3 tabs) - Experienced - Theme Parks & Rolling, Amazing & Terrifying I quickly summarized my experience with shrooms and lsd, because they are the 2 most intense drugs I've ever used, which can offer some comparison of the intensity of this roll. Weed - Daily smoker. Usually only once a day.

    scraped 2026-03-14
    Cannabis 1 5 Grams Vaporized – Lifelong Stoner – “wombstone” neutral

    0:00 I haven’t had any weed for six days which is like some kind of record for me. Can’t remember the last time I made it this far. I’ve been smoking five or six joints a day, minimum, for months despite the fact that I own a perfectly good vaporizer. In the end there were more roaches in the house than roaches.

    scraped 2026-03-14
    Cannabis Last Experience Drowning Dying W Mary Jane neutral

    Marajuana -- Last Experience -- Drowning & Dying w/ Mary Jane. Drowning & Dying With Mary Jane. (on 3/15/02) Sandra patted me on the back and congratulated me -- I'd finally inhaled correctly. I'm always trying to do it too quickly, but I inhaled slowly and then a bit deeper when I took my finger of the air hole.

    scraped 2026-03-14
    Cannabis Oral High Dose Exp Brownies Resulted In Hospital Trip On cautionary

    So, this is hard to piece together as I don't remember anything too clearly. I am partially going off of other's accounts, but I cannot separate the "dreams" I had from reality that went on during this night. It is really hard to recount the story.

    scraped 2026-03-14
    Cannabis Years Of Experience Heart Attack Panic Attack Flashback cautionary

    Marijuana - Years of Experience - Heart Attack? Panic Attack? Flashback? Hey there, I've smoked weed for about 2 and a bit years and I've had more than my fair share of experiences including bad and terrible ones. Just recently though, this weekend I had 2 COMPLETE freak outs like I have never had before.

    scraped 2026-03-14

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