THC - Substance Search

Summary Erowid TripSit

Dronabinol is a synthetic form of delta-9-THC, the primary active ingredient in Cannabis. It is presecribed as an appetite stimulant and for treating neuropathic pain in the United States. Dronabinol is one of the examples used to point out the inconsistency of the U.S. and U.N. controlled substance rules and definitions because THC both falls under the classifications as "no accepted medical use" and "accepted medical use".

Dose Information TripSit PsychonautWiki

ROA	Light	Common	Strong	Heavy
Oral	10-20mg	20-30mg	30-50mg	50mg+
Smoked	10-20mg	20-60mg	60-100mg	100mg+

Light Common Strong Heavy

Onset, Duration & After-effects TripSit PsychonautWiki

ROA	Onset	Peak	Offset	After Effects	Total
Oral	30-120 minutes	4-12 hrs	4-6 hrs	1-4 hrs	8.5-20 hrs
Smoked	1-10 min	1-4 hrs	3-4 hrs	2-24 hrs	4-8.2 hrs

Effect Profile

94 reports

Scores (1–10) curated from multiple sources:

Effect keyword matching from PsychonautWiki catalog
Validated against 94 Erowid trip reports
Weighted by importance: core (×3), major (×2), minor (×1)

Full methodology

Psychedelic 6.6

Strong+ 7/10

Strong visuals, body load, and auditory effects with mild headspace

Visual Intensity ×3

10

color enhancement drifting brightened colour

Headspace Depth ×3

5

time distortion confusion

Auditory Effects ×1

8

⚠ Body Load / Somatic Effects ×1

10

nausea vasoconstriction increased heart rate

Stimulant 6.5

Strong 6/10

Strong stimulation, anxiety/jitters, and euphoria with low focus

Stimulation / Energy ×3

10

stimulation wakefulness alertness enhancement

Euphoria / Mood Lift ×2

8

euphoria cognitive euphoria

Focus / Productivity ×2

3

⚠ Anxiety / Jitters ×1

10

anxiety restlessness increased heart rate vasoconstriction

Based on reports from:

Effect Index Brief Unity on Weed Erowid Experience Reports PsychonautWiki THC

Tolerance

Build-up develops gradually over weeks of daily use; subjective effects diminish before physiological tolerance

Reset 2–4 weeks for most users; heavy users may need longer (up to 90 days for full CB1 receptor reset)

Tolerance Decay

Full tolerance 10d Half tolerance 14d Baseline ~28d

Based on human imaging and clinical studies showing CB1 down‑regulation with daily use and reversal over days–weeks. Model is approximate and varies with dose, frequency, and route. Data quality: mixed clinical/anecdotal.

Cross-Tolerances

Other CB1‑active cannabinoids

50%

Effects Erowid

Aggregated from 94 Erowid experience reports

Positive Effects 12

Anxiety Suppression 47.9% 70%

Music Enhancement 38.3% 70%

Stimulation 34.0% 70%

Color Enhancement 31.9% 70%

Euphoria 30.9% 70%

Empathy 25.5% 70%

Focus Enhancement 24.5% 70%

Sedation 22.3% 70%

Tactile Enhancement 17.0% 70%

Body High 11.7% 70%

Introspection 8.5% 70%

Creativity Enhancement 4.3% 70%

Adverse Effects 13

Confusion 29.8% 70%

Nausea 26.6% 70%

Memory Suppression 8.5% 70%

Muscle Tension 6.4% 70%

Motor Impairment 6.4% 70%

Increased Heart Rate 6.4% 70%

Jaw Clenching 5.3% 70%

Headache 4.3% 70%

Psychosis 4.3% 70%

Sweating 4.3% 70%

Seizure 4.3% 70%

Appetite Suppression 3.2% 70%

Thought Loops 3.2% 70%

Combinations TripSit

Trip Reports Effect Index

Brief Unity on Weed Maethor

Pill Identifiers

6 known pill identifiers on record — view imprints, colors, shapes, and images

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THC's nerd page Pharmacology, chemical data, effect profiles, and more

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Helpful Links

📘 Experience Reports 📖 Erowid 📖 TripSit 📖 PsychonautWiki