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    Agmatine Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 1 source
    • 1 ROA with full dose ladder
    • duration data present
    • 19 combo interactions documented
    • dose data not in PW/TripSit (unverifiable)

    Aliases: 4-aminobutylguanidine, Decarboxylated arginine, 1-amino-4-guanidinobutane

    Nootropic Supplement Opioid

    Summary TheDrug.Wiki

    Agmatine is an endogenous amine stored in synaptic vesicles and released on neuronal activation. It agonises imidazoline I1/I2 sites, inhibits NOS, and blocks NMDA receptor channels in a voltage-dependent manner, collectively producing mild anxiolysis, vascular smooth-muscle relaxation, and anti-addictive effects. Oral bioavailability is roughly 30%, with plasma half-life 75-120 min but brain/spinal half-life ~12 h, explaining why twice-daily split dosing maintains opioid-tolerance–reversal despite short plasma kinetics.

    Dose Information TheDrug.Wiki

    ROA Light Common Strong Heavy
    Oral 100-250mg 250-1000mg 1000-2000mg 2000mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki

    ROA Onset Peak Offset Total
    Oral 30-60 min 1-3 hrs 2-4 hrs 3-6 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Opioid 2.4
    Light 2/10

    Mild pain relief and itching/nausea with low sedation

    Euphoria / Warmth ×3
    0
    Analgesia ×2
    4
    pain relief
    Sedation / Relaxation ×1
    3
    sedation
    ⚠ Itching / Nausea ×1
    4
    nausea
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Agmatine
    View methodology →

    Tolerance

    Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
    Reset 7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk

    Tolerance Decay

    Half tolerance 7d Baseline ~35d

    Formal human tolerance data are lacking. Many community users report reduced subjective benefit after several consecutive daily doses and partial restoration after several days off; pattern suggests short‑term tachyphylaxis. Data quality: anecdotal.

    Cross-Tolerances

    NMDA antagonists (possible)
    20%

    Effects TheDrug.Wiki

    Positive
    • Anxiolysis
    • Pain relief
    • Stimulation
    • Increased energy
    Negative
    • Insomnia
    • Nausea
    • Headache
    Neutral
    • Vasodilation
    • Stimulation or sedation
    • Sedation
    Positive
    • Cognitive enhancement
    • Mood enhancement
    • Motivation enhancement
    • Focus enhancement
    • Stress reduction
    • Emotional enhancement
    • Memory enhancement
    • Mild euphoria
    • Anxiety suppression
    • Emotion enhancement
    • Empathy enhancement
    • Addiction suppression
    Positive
    • Physical enhancement
    Negative
    • Light sensitivity
    • Disinhibition
    • Appetite suppression
    • Spatial disorientation
    • Derealization
    Neutral
    • Dulled perception
    • Visual distortions
    • Visual disconnection
    • Metallic taste

    Combinations TripSit

    Cross-Check Agmatine with another substance

    Agmatine's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    💊 Pill Identifier 📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki