Agmatine
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- dose data not in PW/TripSit (unverifiable)
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- dose data not in PW/TripSit (unverifiable)
Aliases: 4-aminobutylguanidine, Decarboxylated arginine, 1-amino-4-guanidinobutane
Summary
Agmatine is an endogenous amine stored in synaptic vesicles and released on neuronal activation. It agonises imidazoline I1/I2 sites, inhibits NOS, and blocks NMDA receptor channels in a voltage-dependent manner, collectively producing mild anxiolysis, vascular smooth-muscle relaxation, and anti-addictive effects. Oral bioavailability is roughly 30%, with plasma half-life 75-120 min but brain/spinal half-life ~12 h, explaining why twice-daily split dosing maintains opioid-tolerance–reversal despite short plasma kinetics.
Dose Information
Dose basis. Community use typically 250–1,000 mg per dose. A human open‑label case series for neuropathic pain used 2.67 g/day for 2 months without serious adverse events reported; higher daily intakes appear to increase rates of GI upset and dizziness. Evidence base is limited; dosing guidance is largely derived from user reports with one small human series. (Dose figures and this note are from Drugs.Wiki.)
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 100-250mg | 250-1000mg | 1000-2000mg | 2000mg+ |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 15-30 min | 30-60 min | 1-3 hrs | 2-4 hrs | 3.75-8.5 hrs |
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track Agmatine there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
Agmatine Source: SubstanceSearch (substancesearch.com) Oral dose (mg): threshold 50 · light 100-250 · common 250-1000 · strong 1000-2000 · heavy 2000+ Oral duration: onset 15-30m · come-up 0.5-1h · peak 1-3h · offset 2-4h · total 3.75-8.5h · after-effects 12h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 625 mg (Oral).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Cross-Tolerances
Effects
- Anxiolysis
- Pain relief
- Stimulation
- Increased energy
- Insomnia
- Nausea
- Headache
- Vasodilation
- Stimulation or sedation
- Sedation
- Cognitive enhancement
- Mood enhancement
- Motivation enhancement
- Focus enhancement
- Stress reduction
- Emotional enhancement
- Memory enhancement
- Mild euphoria
- Anxiety suppression
- Emotion enhancement
- Empathy enhancement
- Addiction suppression
- Physical enhancement
- Light sensitivity
- Disinhibition
- Appetite suppression
- Spatial disorientation
- Derealization
- Dulled perception
- Visual distortions
- Visual disconnection
- Metallic taste
Helpful Links
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