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    alpha-PCYP molecular structure

    alpha-PCYP Stats & Data

    Alpha-pyrrolidinocyclohexanophenone
    NPS DataHub
    MW271.4
    FormulaC18H25NO
    IUPAC2-cyclohexyl-1-phenyl-2-(pyrrolidin-1-yl)ethanone
    SMILESO=C(c1ccccc1)C(C1CCCCC1)N1CCCC1
    InChIKeyFKEHRWJWTWDTDB-UHFFFAOYSA-N
    Phenethylamines; Cathinones; 2020/1. Von 2-Phenethylamin abgeleitete Verbindungen; 2021/1. Von 2-Phenethylamin abgeleitete Verbindungen; 2022/1. Von 2-Phenethylamin abgeleitete Verbindungen
    Chemical Class Amphetamine
    Psychoactive Class Stimulant
    Half-Life Unknown in humans (no published pharmacokinetic data).

    Receptor Profile

    Receptor Actions

    Inhibitors
    Dopamine-norepinephrine reuptake inhibitor (NDRI)
    Dopamine transporter inhibitor (high potency)

    Effect Profile

    Curated
    Stimulant 6.1

    Strong euphoria and anxiety/jitters with moderate focus, mild stimulation

    Stimulation / Energy×3
    5
    Euphoria / Mood Lift×2
    10
    Focus / Productivity×2
    7
    Anxiety / Jitters×1
    10

    Tolerance & Pharmacokinetics

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    Half-Life
    Unknown in humans (no published pharmacokinetic data).
    Addiction Potential
    Moderate to high; pyrrolidinophenones are widely reported to encourage compulsive redosing and binges, increasing psychological dependence risk.

    Tolerance Decay

    Full tolerance 2d Half tolerance 7d Baseline ~14d

    Tolerance appears to build rapidly with binges and decays over 1–4 weeks, extrapolated from stimulant class patterns and community accounts; data remain anecdotal, so spacing sessions by several weeks is prudent. Avoid consecutive-day use.

    Cross-Tolerances

    Other pyrrolidinophenone cathinones (e.g., α‑PVP, α‑PHP)
    70% ●○○
    Amphetamines (partial)
    30% ●○○

    Harm Reduction

    drugs.wiki

    Identity: α‑PCYP is a pyrrolidinophenone cathinone; structural identifiers (InChIKey FKEHRWJWTWDTDB) are cataloged by chemistry databases and compendia, confirming nomenclature and class. This backs using class-based harm reduction where substance-specific data are sparse. Route risks: Snorting cathinones is frequently linked to significant nasal and throat irritation and chemical burns; oral routes are typically less damaging to mucosa. Users often report harshness when vaporizing α‑PCYP or similar pyrrolidinophenones. Prefer oral, avoid vaporizing, and if insufflating, use sterile tools and saline care. Compulsive use/psychosis: Cathinones—especially pyrrolidinophenones like α‑PVP—are consistently associated with compulsive redosing, insomnia, paranoia and psychotic episodes. Set strict limits, schedule sleep, and stop at early warning signs (racing thoughts, overheating, suspicious ideation). Cardiovascular strain/overheating: Stimulants raise heart rate and temperature; combining with other stimulants heightens risk. Keep cool, rest periodically, and hydrate modestly (about 250 ml/hour at rest, up to ~500 ml/hour if active). Avoid heavy exertion in hot settings. Drug checking: Mislabeling within the pyrrolidinophenone market is well documented (e.g., α‑PVP sold as 3‑MMC; α‑PiHP sold as 2C‑B). Use accredited drug checking when possible; note FTIR’s ~5% detection limit—trace adulterants may be missed—so single tests can be misleading. Start with very small doses even after testing. Polydrug caution: Alcohol and sedatives can increase risky behavior and mask stimulant intoxication; ‘balancing’ uppers and downers raises overdose/accident risk. If severe agitation, chest pain, or hyperthermia occur, seek medical help; do not self‑treat with more substances. Limited evidence base: Human pharmacokinetics for α‑PCYP are uncharacterized; most info comes from community reports and forensic listings. Treat all dose/duration figures as rough; individual variability is high.

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