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    alpha-PiHP molecular structure

    alpha-PiHP Stats & Data

    Pihp Funky 4-me-pvp Alpha-phip a-pihp
    NPS DataHub
    MW245.36
    FormulaC16H23NO
    IUPAC4-methyl-1-phenyl-2-pyrrolidin-1-ylpentan-1-one
    SMILESCC(C)CC(N1CCCC1)C(=O)c1ccccc1
    InChIKeyUOZWZANRCOALQL-UHFFFAOYSA-N
    Phenethylamines; Cathinones; 2020/1. Von 2-Phenethylamin abgeleitete Verbindungen; 2021/1. Von 2-Phenethylamin abgeleitete Verbindungen; 2022/1. Von 2-Phenethylamin abgeleitete Verbindungen
    Chemical Class Amphetamine
    Psychoactive Class Stimulant
    Half-Life Unknown in humans; user reports suggest a several‑hour effect window consistent with short‑acting stimulants (roughly 2–5 h active period when not redosing).

    Pharmacology

    DrugBank

    Description

    α-PHiP (also known as α-PiHP), is a stimulant drug of the cathinone class that has been sold online as a designer drug. It is a positional isomer of pyrovalerone, with the methyl group shifted from the 4-position of the aromatic ring to the 4-position of the acyl chain. In a classic 2006 study of pyrrolidinyl cathinone derivatives by Meltzer et al. at Organix, the alpha-isobutyl derivative of pyrovalerone, O-2494, was found to have the highest potency in vitro as an inhibitor of the dopamine transporter of the alpha substituted derivatives tested, however it was not until ten years later in July 2016 that α-PHiP was first identified as a designer drug, when it was reported to the EMCDDA by a forensic laboratory in Slovenia.

    Effect Profile

    Curated + 2 Reports
    Empathogen 3.4

    Moderate stimulation and euphoria with mild sensory enhancement

    Empathy / Social Openness×3
    0
    Euphoria / Mood Elevation×2
    6
    Stimulation×1
    7
    Sensory Enhancement×1
    5
    Stimulant 5.4

    Strong anxiety/jitters with moderate euphoria and focus, mild stimulation

    Stimulation / Energy×3
    5
    Euphoria / Mood Lift×2
    7
    Focus / Productivity×2
    7
    Anxiety / Jitters×1
    10

    Tolerance & Pharmacokinetics

    drugs.wiki
    Half-Life
    Unknown in humans; user reports suggest a several‑hour effect window consistent with short‑acting stimulants (roughly 2–5 h active period when not redosing).
    Addiction Potential
    High. Pyrrolidinophenone cathinones ("pyros") show strong reinforcement and craving, especially when vaporized; users frequently report binge patterns and difficulty stopping within a session.

    Tolerance Decay

    Full tolerance 1d Half tolerance 3d Baseline ~14d

    Within‑session acute tolerance to euphoria rises rapidly; next‑day effects are often blunted while side‑effects remain. Rough return to baseline sensitivity typically requires 1–2 weeks after heavy use. Data primarily from user reports; individual variability high.

    Cross-Tolerances

    α‑PVP / MDPV / α‑PHP (other pyrrolidinophenones)
    60% ●○○

    Experience Report Analysis

    Erowid
    2 Reports
    2023–2024 Date Range
    1 With Age Data

    Demographics

    Gender Distribution

    Age Distribution

    Reports Over Time

    Harm Reduction

    drugs.wiki

    Potent NPS stimulant of the pyrrolidinophenone family closely related to α‑PVP/α‑PHP; typically appears as white/off‑white powder or crystals. Batch potency varies widely across vendors and time—use a 0.001 g scale, allergy test (≈1 mg), and incremental titration. Vaporization has the fastest onset and the highest redose liability; many users report compulsive re‑hitting leading to binges, sleep loss, and anxiety spikes. Insufflation is commonly described as notably caustic to nasal mucosa, with increasing irritation and nosebleeds across a session; post‑use saline rinses and spacing lines reduce harm. Cardiovascular strain (tachycardia, hypertension), vasoconstriction (cold extremities), hyperthermia with exertion, and severe insomnia are the most common acute risks; avoid heat, hydrate with electrolytes, and rest. If anxious or paranoid, reduce stimulation, cool down, and consider non‑sedating de‑escalation first; if a benzodiazepine is used, avoid redoses and combining with other depressants due to blackout/respiratory risk. Set a pre‑commitment: cap session total and stop‑time to disrupt redosing loops—many binges escalate after the first hour. Adulteration/misrepresentation occurs in street pills/powders; use reagent tests and, where possible, submit samples to a lab‑based drug checking service. Extended binges increase risk of psychosis‑like symptoms; sleep, nutrition, and at least several days of abstinence are protective. Data on human pharmacokinetics is sparse; avoid frequent reuse within the same week to limit tolerance and sleep debt.

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