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    Disclaimer
    ☠ This substance has been associated with serious adverse events including fatalities. Use extreme caution.
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.
    ⚠ Synthetic cannabinoids are far more potent and unpredictable than natural cannabis. They lack a ceiling effect and have been linked to seizures, psychosis, and death.

    AM-2201

    Aliases: am2201

    Categories

    Psychedelic Research-chemical Cannabinoid
    AM-2201 structure

    Summary TheDrug.Wiki TripSit

    AM-2201 is an extremely potent full agonist at CB1/CB2 receptors (~4–10× potency of JWH-018). Milligram-accurate weighing (0.000 mg resolution) and volumetric dilution are strongly recommended; eyeballing plant material almost always leads to overdose. Acute toxicity can include severe anxiety, hypertension, tachyarrhythmia, hyperemesis, and generalized tonic–clonic seizures. Fatalities have been associated with polydrug use and high ambient temperatures (heat stroke). Users should have a sober sitter and avoid driving for several hours after use.

    Dose Information TheDrug.Wiki TripSit

    ROA Light Common Strong Heavy
    Vaporized 250-500ug 500-1000ug 1–2mg 2µg+
    Smoked - - 1–2mg 2µg+
    Vapourized 250-500ug 500-1000ug 1000-2000ug 2000ug+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit

    ROA Onset Peak Offset After Effects
    Vaporized 1-3 min 5-15 min 20-60 min 0.5-2 hrs
    Smoked 1-3 min 5-15 min 20-60 min 0.5-2 hrs
    Oral 15-30 min 45-90 min 20-60 min 0.5-2 hrs
    Vapourized 1-3 min 30-90 min - 15-60 min

    Tolerance

    Build-up develops over weeks of regular use via CB1 receptor downregulation
    Reset 2–4 weeks for most users; heavy users may need longer

    Effects TheDrug.Wiki

    Positive
    • Powerful body high
    • Muscle relaxation
    • Physical euphoria
    Negative
    • Tachycardia
    • Dry mouth
    • Profuse sweating
    • Nausea / vomiting
    • Convulsions/seizures
    • Respiratory depression
    Neutral
    • Sedation
    Positive
    • Rapid euphoria
    • Enhanced music appreciation
    • Anxiety suppression
    Negative
    • Short-term memory suppression
    • Anxiety / panic
    • Paranoia
    • Irritability on comedown
    Neutral
    • Altered time perception
    • Mental fog
    • Derealisation
    Positive
    • Color enhancement
    • Increased libido
    Negative
    • Disinhibition
    • Double vision
    Neutral
    • Visual distortion at high dose
    • Stimulus control loss
    • Visual distortions
    • Dulled perception
    • Internal hallucination
    • Internal hallucinations

    Combinations TripSit

    Helpful Links

    📘 Experience Reports 📖 PsychonautWiki 📖 The Drug Users Bible