Summary
AM-2233 is a full CB1/CB2 agonist with sub-nanomolar affinity; overdose margins are extremely narrow. Weigh doses with a 0.1 mg-resolution scale or use volumetric dosing. CRITICAL WARNING: AM-2233 is notably associated with severe and persistent tinnitus (ringing in the ears), even at moderate doses, which may last for hours to days. Acute adverse events include severe anxiety, panic, auditory hallucinations, visual distortions, tachycardia, hypertension, seizures, acute kidney injury, and rhabdomyolysis. Very limited human data exist; long-term neurotoxicity is unknown.
Dose Information
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | After Effects |
|---|---|---|---|---|
| Smoked | 1-2 min | 5-20 min | 30-90 min | 2-6 hrs |
| Oral | 15-45 min | 0.75-2 hrs | 30-90 min | 2-6 hrs |
Tolerance
Build-up
develops over weeks of regular use via CB1 receptor downregulation
Reset
2–4 weeks for most users; heavy users may need longer
Effects
Positive
- Analgesia
Negative
- Tachycardia
- Dry mouth
- Nausea
- Rapid tolerance buildup
- Bodily pressures
- Increased heart rate
- Body lightness or heaviness
- Sedation
- Red eye
Positive
- Euphoria
- Anxiety suppression
- Cognitive euphoria
- Emotion enhancement
Negative
- Anxiety
- Paranoia
- Memory suppression
- Confusion
- Rapid intoxication
- Time distortion
Positive
- Color enhancement
- Visual enhancement
- Appetite enhancement
- Increased libido
Negative
- Tinnitus
- Auditory suppression
- Disinhibition
- Visual distortions
- Closed-eye imagery
- Dulled perception