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    Disclaimer
    ☢ This substance has an extremely narrow safety margin. Small dosing errors can lead to life-threatening effects.
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.
    ⚠ Synthetic cannabinoids are far more potent and unpredictable than natural cannabis. They lack a ceiling effect and have been linked to seizures, psychosis, and death.

    AM-2233 Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 2 corroborating sources
    • 2 ROAs with full dose ladders
    • duration data present
    • 16 combo interactions documented
    • classified Research-chemical
    • dose data not in PW/TripSit (unverifiable)

    Aliases: Cs-325

    Psychedelic Research-chemical Cannabinoid

    Summary TheDrug.Wiki

    AM-2233 is a full CB1/CB2 agonist with sub-nanomolar affinity; overdose margins are extremely narrow. Weigh doses with a 0.1 mg-resolution scale or use volumetric dosing. CRITICAL WARNING: AM-2233 is notably associated with severe and persistent tinnitus (ringing in the ears), even at moderate doses, which may last for hours to days.

    Dose Information TheDrug.Wiki

    ROA Light Common Strong Heavy
    Smoked 0.5-1mg 1-2mg 2-4mg 4mg+
    Oral 2-3mg 3-5mg 5-8mg 8mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki

    ROA Onset Peak Offset After Effects Total
    Smoked - 5-20 min 30-90 min 2-6 hrs 1-3 hrs
    Oral 15-45 min 5-20 min 30-90 min 2-6 hrs 1-3 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 4.2
    Moderate 4/10

    Moderate body load with mild visuals, headspace, and auditory effects

    Visual Intensity ×3
    5
    color enhancement visual enhancement visual distortions
    Headspace Depth ×3
    4
    emotion enhancement time distortion confusion
    Auditory Effects ×1
    4
    auditory suppression tinnitus
    ⚠ Body Load / Somatic Effects ×1
    7
    nausea bodily pressures tachycardia increased heart rate
    Based on reports from:
    Erowid Experience Reports PsychonautWiki AM-2233
    View methodology →

    Tolerance

    Build-up develops over weeks of regular use via CB1 receptor downregulation
    Reset 2–4 weeks for most users; heavy users may need longer

    Tolerance Decay

    Full tolerance 3d Half tolerance 10d Baseline ~35d

    Tolerance to CB1-mediated effects can build within days of daily exposure and tends to remit over weeks; estimates extrapolated from cannabinoid class observations and user reports. Data quality is limited and highly variable between compounds and users.

    Cross-Tolerances

    cannabis
    50%
    other synthetic cannabinoids
    60%

    Effects TheDrug.Wiki

    Positive
    • Analgesia
    Negative
    • Tachycardia
    • Dry mouth
    • Nausea
    • Rapid tolerance buildup
    • Bodily pressures
    • Increased heart rate
    Neutral
    • Body lightness or heaviness
    • Sedation
    • Red eye
    Positive
    • Euphoria
    • Anxiety suppression
    • Cognitive euphoria
    • Emotion enhancement
    Negative
    • Anxiety
    • Paranoia
    • Memory suppression
    • Confusion
    Neutral
    • Rapid intoxication
    • Time distortion
    Positive
    • Color enhancement
    • Visual enhancement
    • Appetite enhancement
    • Increased libido
    Negative
    • Tinnitus
    • Auditory suppression
    • Disinhibition
    Neutral
    • Visual distortions
    • Closed-eye imagery
    • Dulled perception

    Combinations TripSit

    Cross-Check AM-2233 with another substance

    AM-2233's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki