AM-2233
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 3 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 16 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
- 3 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 16 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Aliases: Cs-325
Summary
AM-2233 is a full CB1/CB2 agonist with sub-nanomolar affinity; overdose margins are extremely narrow. Weigh doses with a 0.1 mg-resolution scale or use volumetric dosing. CRITICAL WARNING: AM-2233 is notably associated with severe and persistent tinnitus (ringing in the ears), even at moderate doses, which may last for hours to days.
Dose Information
Dose basis. Potency is extremely high (full CB1/CB2 agonist). Community-reported ranges only; human data are sparse. Use a 0.001 g-resolution scale or volumetrically dose to avoid over- or under-reading; TripSit provides a volumetric converter. Begin with an allergy test (≤0.25 mg) and wait a full 20–30 min before redosing because peaks can be delayed and stacking is a common cause of adverse events. These precautions are emphasized for synthetic cannabinoids due to very narrow safety margins and frequent poisonings with this class. Sources: TripSit HR tools; EUDA synthetic cannabinoid harm briefings. Lipophilic; absorption improves with fat/oil carriers (e.g., butter, cream, oils) per user/HR reports. Onset is slower and duration longer than inhalation; avoid redosing for at least 2 h. Community-reported ranges only; measure precisely or use volumetric dosing. Sources: Drugs‑Forum AM‑2233 wiki; TripSit HR tools. (Dose figures and this note are from Drugs.Wiki.)
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Smoked | 0.5-1mg | 1-2mg | 2-4mg | 4mg+ |
| Oral | 2-3mg | 3-5mg | 5-8mg | 8mg+ |
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Smoked | 1-2 min | 5-20 min | 30-90 min | 0.59-1.86 hrs |
| Oral | 15-45 min | 0.75-2 hrs | 30-90 min | 1.5-4.25 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Moderate body load with mild visuals, headspace, and auditory effects
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track AM-2233 there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
AM-2233 Source: SubstanceSearch (substancesearch.com) Smoked dose (mg): threshold 0.25 · light 0.5-1 · common 1-2 · strong 2-4 · heavy 4+ Oral dose (mg): threshold 1 · light 2-3 · common 3-5 · strong 5-8 · heavy 8+ Smoked duration: onset 1-2m · peak 5-20m · offset 0.5-1.5h · total 0.59-1.86h · after-effects 2-6h Oral duration: onset 15-45m · peak 0.75-2h · offset 0.5-1.5h · total 1.5-4.25h · after-effects 2-6h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 1.5 mg (Smoked).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Tolerance to CB1-mediated effects can build within days of daily exposure and tends to remit over weeks; estimates extrapolated from cannabinoid class observations and user reports. Data quality is limited and highly variable between compounds and users.
Cross-Tolerances
Effects
- Analgesia
- Tachycardia
- Dry mouth
- Nausea
- Rapid tolerance buildup
- Bodily pressures
- Increased heart rate
- Body lightness or heaviness
- Sedation
- Red eye
- Euphoria
- Anxiety suppression
- Cognitive euphoria
- Emotion enhancement
- Anxiety
- Paranoia
- Memory suppression
- Confusion
- Rapid intoxication
- Time distortion
- Color enhancement
- Visual enhancement
- Appetite enhancement
- Increased libido
- Tinnitus
- Auditory suppression
- Disinhibition
- Visual distortions
- Closed-eye imagery
- Dulled perception
Combinations
Cross-Check AM-2233 with another substanceHelpful Links
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