AM-2233
Aliases: Cs-325
Summary
AM-2233 is a full CB1/CB2 agonist with sub-nanomolar affinity; overdose margins are extremely narrow. Weigh doses with a 0.1 mg-resolution scale or use volumetric dosing. CRITICAL WARNING: AM-2233 is notably associated with severe and persistent tinnitus (ringing in the ears), even at moderate doses, which may last for hours to days.
Dose Information
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset |
|---|---|---|---|
| Smoked | 1-2 min | 5-20 min | 30-90 min |
| Oral | 15-45 min | 0.75-2 hrs | 30-90 min |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Psychedelic
4.2
Moderate
4/10
Moderate body load with mild visuals, headspace, and auditory effects
Visual Intensity
×3
5
color enhancement
visual enhancement
visual distortions
Headspace Depth
×3
4
emotion enhancement
time distortion
confusion
Auditory Effects
×1
4
auditory suppression
tinnitus
Body Load / Somatic Effects
×1
7
nausea
bodily pressures
tachycardia
increased heart rate
Based on reports from:
Tolerance
Build-up
develops over weeks of regular use via CB1 receptor downregulation
Reset
2–4 weeks for most users; heavy users may need longer
Cross-Tolerances
cannabis
50%
Effects
Positive
- Analgesia
Negative
- Tachycardia
- Dry mouth
- Nausea
- Rapid tolerance buildup
- Bodily pressures
- Increased heart rate
- Body lightness or heaviness
- Sedation
- Red eye
Positive
- Euphoria
- Anxiety suppression
- Cognitive euphoria
- Emotion enhancement
Negative
- Anxiety
- Paranoia
- Memory suppression
- Confusion
- Rapid intoxication
- Time distortion
Positive
- Color enhancement
- Visual enhancement
- Appetite enhancement
- Increased libido
Negative
- Tinnitus
- Auditory suppression
- Disinhibition
- Visual distortions
- Closed-eye imagery
- Dulled perception
Combinations
AM-2233's nerd page
Pharmacology, chemical data, effect profiles, and more
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