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    Disclaimer
    ☢ This substance has an extremely narrow safety margin. Small dosing errors can lead to life-threatening effects.
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.
    ⚠ Synthetic cannabinoids are far more potent and unpredictable than natural cannabis. They lack a ceiling effect and have been linked to seizures, psychosis, and death.

    AM-2233 Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 3 corroborating sources
    • 2 ROAs with full dose ladders
    • duration data present
    • 27 combo interactions documented
    • classified Research-chemical
    • dose data not in PW/TripSit (unverifiable)

    Aliases: Cs-325

    Psychedelic Research-chemical Cannabinoid

    Summary dose.wiki

    AM-2233 is a full CB1/CB2 agonist with sub-nanomolar affinity; overdose margins are extremely narrow. Weigh doses with a 0.1 mg-resolution scale or use volumetric dosing. CRITICAL WARNING: AM-2233 is notably associated with severe and persistent tinnitus (ringing in the ears), even at moderate doses, which may last for hours to days.

    Dose Information Drugs.Wiki

    Dose basis. Smoked: Potency is extremely high (full CB1/CB2 agonist). Community-reported ranges only; human data are sparse. Use a 0.001 g-resolution scale or volumetrically dose to avoid over- or under-reading; TripSit provides a volumetric converter. Begin with an allergy test (≤0.25 mg) and wait a full 20–30 min before redosing because peaks can be delayed and stacking is a common cause of adverse events. These precautions are emphasized for synthetic cannabinoids due to very narrow safety margins and frequent poisonings with this class. Sources: TripSit HR tools; EUDA synthetic cannabinoid harm briefings. Oral: Lipophilic; absorption improves with fat/oil carriers (e.g., butter, cream, oils) per user/HR reports. Onset is slower and duration longer than inhalation; avoid redosing for at least 2 h. Community-reported ranges only; measure precisely or use volumetric dosing. Sources: Drugs‑Forum AM‑2233 wiki; TripSit HR tools. (Dose figures and this note are from Drugs.Wiki.)

    ROA Light Common Strong Heavy
    Smoked 0.5-1mg 1-2mg 2-4mg 4mg+
    Oral 2-3mg 3-5mg 5-8mg 8mg+
    Light Common Strong Heavy
    Sources

    Smoked

    Dose ladder — Drugs.Wiki

    Oral

    Dose ladder — Drugs.Wiki

    Onset, Duration & After-effects dose.wiki Drugs.Wiki

    ROA Onset Peak Offset After Effects Total
    Smoked 1-2 min 5-20 min 30-90 min 2-6 hrs 0.59-1.86 hrs
    Oral 15-45 min 0.75-2 hrs 30-90 min 2-6 hrs 1.5-4.25 hrs

    Effect Profile

    Scores (0–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 4.2
    Moderate 4/10

    Mild visuals, headspace, and auditory effects with moderate body load

    Visual Intensity ×3
    5
    color enhancement visual enhancement visual distortions
    Headspace Depth ×3
    4
    emotion enhancement time distortion confusion
    Auditory Effects ×1
    4
    auditory suppression tinnitus
    ⚠ Body Load / Somatic Effects ×1
    7
    nausea bodily pressures tachycardia increased heart rate
    View methodology →

    Tolerance

    Build-up develops over weeks of regular use via CB1 receptor downregulation
    Reset 2–4 weeks for most users; heavy users may need longer

    Tolerance Decay

    Full tolerance 3d Half tolerance 10d Baseline ~35d

    Tolerance to CB1-mediated effects can build within days of daily exposure and tends to remit over weeks; estimates extrapolated from cannabinoid class observations and user reports. Data quality is limited and highly variable between compounds and users.

    Cross-Tolerances

    cannabis
    other synthetic cannabinoids

    Effects dose.wiki

    Positive
    Negative
    Neutral
    • Body lightness or heaviness
    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral

    Combinations

    Cross-Check AM-2233 with another substance

    AM-2233's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📖 dose.wiki
    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track AM-2233 there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "AM-2233 (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    AM-2233
    Unit
    mg
    Description 
    AM-2233
Source: SubstanceSearch (substancesearch.com)

Smoked dose (mg): threshold 0.25 · light 0.5-1 · common 1-2 · strong 2-4 · heavy 4+
Oral dose (mg): threshold 1 · light 2-3 · common 3-5 · strong 5-8 · heavy 8+

Smoked duration: onset 1-2m · peak 5-20m · offset 0.5-1.5h · total 0.59-1.86h · after-effects 2-6h
Oral duration: onset 15-45m · peak 0.75-2h · offset 0.5-1.5h · total 1.5-4.25h · after-effects 2-6h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 1.5 mg (Smoked).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.