Aniracetam - Substance Search

Summary TheDrug.Wiki Erowid TripSit PsychonautWiki

Fat-soluble compound requiring dietary fat for optimal absorption. Oral bioavailability of parent drug is very low (~10%); most central activity believed to come from active metabolites (notably N-anisoyl-GABA and 2-pyrrolidinone). Users often stack with choline sources (CDP-choline, alpha-GPC) to reduce racetam-type headaches, though clinical necessity is unproven.

Dose Information TheDrug.Wiki TripSit PsychonautWiki

ROA	Light	Common	Strong	Heavy
Oral	500-1200mg	1200-1800mg	1800-2400mg	2400mg+
Sublingual	500-1200mg	1200-1800mg	1800-2400mg	2400mg+

Light Common Strong Heavy

Onset, Duration & After-effects TheDrug.Wiki TripSit PsychonautWiki

ROA	Onset	Comeup	Peak	Offset	After Effects	Total
Oral	20-90 min	30-60 min	1-2 hrs	1-2 hrs	1-4 hrs	2.8-6.5 hrs
Sublingual	5-30 min	15-30 min	1-2 hrs	1-2 hrs	1-4 hrs	2.3-5 hrs

Tolerance

Build-up develops over 1–4 weeks of regular use

Reset days to weeks depending on duration of use

Tolerance Decay

Full tolerance 21d Half tolerance 7d Baseline ~14d

Patterns are largely anecdotal. Many users rotate racetams or limit use to 2–4 days/week to preserve effects. Headache propensity appears linked to individual cholinergic sensitivity. Evidence base: community reports and Erowid experience summaries.