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    Arecoline Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 1 source
    • 4 ROAs with full dose ladders
    • duration data present
    • PubChem toxicity data
    • dose data not in PW/TripSit (unverifiable)

    Aliases: Arecolin, Arecaline, Arecholine, Betel nut alkaloid

    Stimulant Nootropic

    Summary TheDrug.Wiki

    One average areca nut (~2 g) contains ~5-8 mg arecoline. Calcium hydroxide or slaked lime is traditionally added to basify saliva and improve buccal absorption, but greatly increases oral carcinogen formation. Chronic areca nut use is classified as a Group 1 carcinogen by IARC with strong evidence for oral cancer, submucous fibrosis, and systemic health effects.

    Dose Information TheDrug.Wiki

    ROA Light Common Strong Heavy
    Buccal 2-4mg 4-8mg 8-15mg 15mg+
    Oral 3-6mg 6-10mg 10-15mg 15mg+
    Sublingual 2-5mg 5-10mg 10-15mg 15mg+
    Vaporized 1-3mg 3-6mg 6-10mg 10mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki

    ROA Onset Peak Offset After Effects Total
    Buccal - 12-42 min 30-90 min 1-3 hrs 1-2 hrs
    Oral 15-25 min 12-42 min 30-90 min 1-3 hrs 1-2 hrs
    Sublingual 2-5 min 12-42 min 30-90 min 1-3 hrs 1-2 hrs
    Vaporized - 12-42 min 30-90 min 1-3 hrs 1-2 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Stimulant 5.6
    Strong 6/10

    Strong focus with moderate stimulation, low anxiety/jitters

    Stimulation / Energy ×3
    6
    stimulation wakefulness alertness enhancement
    Euphoria / Mood Lift ×2
    0
    Focus / Productivity ×2
    10
    focus enhancement enhanced concentration cognitive enhancement memory enhancement
    ⚠ Anxiety / Jitters ×1
    3
    anxiety
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Arecoline
    View methodology →

    Tolerance

    Build-up develops over days to weeks of regular use
    Reset 3–7 days for acute tolerance; longer for full reset

    Tolerance Decay

    Full tolerance 7d Half tolerance 3d Baseline ~18d

    Tolerance patterns are inferred from habitual quid users (rapid tolerance to salivation and GI effects, less to cardiovascular effects). Data are low quality and largely anecdotal; sustained daily use tends to increase dose frequency due to short duration.

    Cross-Tolerances

    other direct muscarinic agonists
    50%

    Effects TheDrug.Wiki

    Positive
    • Stimulation
    • Pain Relief
    Negative
    • Nausea
    • Jaw tremor
    • Headache
    Neutral
    • Increased saliva production
    • GI peristalsis
    • Bradycardia
    • Muscle fasciculation
    • Body Odor Alteration
    Positive
    • Enhanced concentration
    • Mild euphoria
    • Cognitive enhancement
    • Alertness enhancement
    • Dream Potentiation
    • Memory Enhancement
    • Focus Enhancement
    • Wakefulness
    Negative
    • Anxiety
    Neutral
    • Talkativeness
    Positive
    • Acuity Enhancement
    • Bodily Control Enhancement
    • Visual Acuity Enhancement
    Negative
    • Warm facial flushing
    • Light sensitivity
    • Appetite Suppression
    • Appetite suppression
    Neutral
    • Olfactory Intensification
    • Drifting
    • Internal hallucination
    Arecoline's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki