Summary
Atomoxetine is a selective norepinephrine reuptake inhibitor (SNRI) approved as a less stimulating treatment for ADHD in 2002 (U.S.). The precise mechanism by which it produces its therapeutic effects is unknown, but is thought to be related to its SNRI action.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 10-18mg | 18-40mg | 40-80mg | 80mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | After Effects | Total |
|---|---|---|---|---|
| Oral | 15-45 min | 8.0-12.0 hrs | 2.0-24.0 hrs | 480-0 min |
Tolerance
Build-up
develops over days to weeks of regular use
Reset
3–7 days for acute tolerance; longer for full reset
Effects
Positive
- Stimulation
- Mental/physical stimulation
Negative
- Increased heart rate
- Pupil dilation
- Insomnia
- Nausea
- Vasoconstriction
- Restlessness
- Sedation
- Decreased appetite
Positive
- Alertness enhancement
- Euphoria
- Cognitive euphoria
- Wakefulness
- Empathy
Negative
- Anxiety
- Confusion
- Compulsive redosing
- Talkativeness
- Time distortion
Positive
- Increased music appreciation
- Color enhancement
- Brightened colour
- Tactile enhancement
Negative
- Light sensitivity
- Disinhibition
- Appetite suppression
- Dehydration
- Dulled perception
- Drifting