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    Bupropion

    Aliases: Zyban, Wellbutrin, Amfebutamone, Wellbutrin xl

    Stimulant Nootropic

    Summary TheDrug.Wiki Erowid TripSit

    Bupropion is a prescription antidepressant and smoking cessation aid with a dose-dependent risk of seizures, particularly above 450 mg/day. It is contraindicated in individuals with seizure disorders, eating disorders (anorexia or bulimia), or during alcohol/benzodiazepine withdrawal. Unlike most antidepressants, bupropion does not typically cause sexual dysfunction or weight gain.

    Dose Information TheDrug.Wiki TripSit

    ROA Light Common Strong Heavy
    Oral 150mg/day 150-300mg/day 300-450mg/day 400+mg(notrecommendedduetoseizurerisk)+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit

    ROA Onset Peak Offset After Effects
    Oral 1-2 hrs 2-4 hrs 6-24 hrs 1-6 hours

    Effect Profile

    178 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Validated against 178 Erowid trip reports
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Stimulant 6.4
    Strong 6/10

    Strong anxiety/jitters and stimulation with moderate euphoria and focus

    Stimulation / Energy ×3
    9
    stimulation increased energy
    Euphoria / Mood Lift ×2
    6
    mood lift motivation enhancement
    Focus / Productivity ×2
    6
    cognitive enhancement motivation enhancement
    ⚠ Anxiety / Jitters ×1
    10
    anxiety restlessness
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Bupropion
    View methodology →

    Tolerance

    Build-up develops rapidly, often within a single session; compulsive redosing common
    Reset a few days for acute tolerance

    Tolerance Decay

    Full tolerance 1h Half tolerance 4d Baseline ~5d

    Effects Erowid

    Aggregated from 178 Erowid experience reports

    Positive Effects 11

    Stimulation 41.6% 70%
    Euphoria 30.9% 70%
    Tactile Enhancement 20.2% 70%
    Music Enhancement 19.1% 70%
    Color Enhancement 19.1% 70%
    Focus Enhancement 15.7% 70%
    Empathy 11.8% 70%
    Body High 9.0% 70%
    Introspection 7.3% 70%
    Pain Relief 5.1% 70%
    Creativity Enhancement 3.4% 70%

    Adverse Effects 13

    Anxiety 43.3% 70%
    Nausea 16.9% 70%
    Confusion 15.2% 70%
    Seizure 14.0% 70%
    Memory Suppression 11.2% 70%
    Increased Heart Rate 11.2% 70%
    Headache 9.0% 70%
    Pupil Dilation 7.9% 70%
    Motor Impairment 6.7% 70%
    Muscle Tension 6.2% 70%
    Psychosis 6.2% 70%
    Jaw Clenching 5.1% 70%
    Sweating 5.1% 70%

    Combinations TripSit

    Pill Identifiers

    15 known pill identifiers on record — view imprints, colors, shapes, and images
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    Bupropion's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    💊 Pill Identifier 📘 Experience Reports 📖 TheDrug.Wiki 📖 TripSit 📖 PsychonautWiki