Summary
Bupropion is a prescription antidepressant and smoking cessation aid with a dose-dependent risk of seizures, particularly above 450 mg/day. It is contraindicated in individuals with seizure disorders, eating disorders (anorexia or bulimia), or during alcohol/benzodiazepine withdrawal. Unlike most antidepressants, bupropion does not typically cause sexual dysfunction or weight gain. Recreational use at high doses can produce unpleasant stimulant and deliriant-like effects. Therapeutic effects for depression may take several weeks to develop.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 150mg/day | 150-300mg/day | 300-450mg/day | 400+mg(notrecommendedduetoseizurerisk)+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | After Effects |
|---|---|---|---|---|
| Oral | 1-2 hrs | 2-4 hrs | 6-24 hrs | 60-0 min |
Tolerance
Build-up
develops rapidly, often within a single session; compulsive redosing common
Reset
a few days for acute tolerance
Effects
Positive
- Stimulation
- Increased energy
- Anxiolysis
Negative
- Insomnia
- Restlessness
- Tremor
- Nausea
- Headache
- Motor impairment
- Sedation
Positive
- Motivation enhancement
- Dream potentiation
- Anxiety suppression
- Mood lift
- Cognitive enhancement
Negative
- Anxiety
- Agitation
- Delirium
- Dizziness
- Motor control loss
Positive
- Physical enhancement
Negative
- Disinhibition
- Appetite suppression
- Light sensitivity
- Spatial disorientation
- Derealization
- Dulled perception
- Visual distortions
- Visual disconnection
- Metallic taste