Butorphanol - Substance Search

Summary TheDrug.Wiki

Butorphanol is marketed as Stadol (human formulation, now discontinued as brand name) and Torbugesic (veterinary). As a potent κ-opioid receptor agonist with partial agonist/antagonist activity at the μ-receptor, it produces analgesia with less respiratory depression than morphine but a high incidence of dysphoria, vertigo, and hallucinatory experiences. Recreational reports describe darkened or tunnel vision, mild warmth, dissociative or salvia-like headspace, and amnestic episodes at higher doses.

Dose Information TheDrug.Wiki

Light Common Strong Heavy

Onset, Duration & After-effects TheDrug.Wiki

ROA	Onset	Comeup	Peak	Offset	After Effects
Intranasal	10-15 min	15-30 min	30-90 min	1-2 hrs	2-6 hrs
Intravenous	1-3 min	5-15 min	30-90 min	1-2 hrs	2-6 hrs
Intramuscular	10-30 min	20-40 min	30-90 min	1-2 hrs	2-6 hrs
Oral	30-60 min	45-90 min	1-2 hrs	1-2 hrs	2-6 hrs

Opioid MME Calculator

⚠ Citation & Disclaimer: Conversion factors sourced from the NIH HEAL Initiative MME Calculator (Adams et al., PAIN 2025), the CDC 2022 Clinical Practice Guideline for Prescribing Opioids for Pain, and the MDCalc MME Calculator. These are approximate equianalgesic ratios for educational reference only. Individual responses vary significantly based on genetics, tolerance, cross-tolerance, and route of administration. This is not medical advice. Do not use these conversions to adjust opioid dosing without professional medical guidance.

Convert from

mg

Convert to

1.42 mg Butorphanol

≈

— mg Morphine

⚠ Equianalgesic dose ratios are approximations and do not account for genetic factors, tolerance, incomplete cross-tolerance, or pharmacokinetic variations. Methadone conversion is especially variable at higher doses. Always consult a healthcare provider before making any changes to opioid therapy.

Effect Profile

12 reports

Scores (1–10) curated from multiple sources:

Effect keyword matching from PsychonautWiki catalog
Weighted by importance: core (×3), major (×2), minor (×1)

Full methodology

Opioid 6.3

Strong 6/10

Strong euphoria with moderate itching/nausea, mild pain relief, low sedation

Euphoria / Warmth ×3

10

physical euphoria euphoria cognitive euphoria mood lift

Analgesia ×2

4

analgesia

Sedation / Relaxation ×1

3

sedation

⚠ Itching / Nausea ×1

7

nausea constipation dry mouth

Based on reports from:

Erowid Experience Reports PsychonautWiki Butorphanol

Tolerance

Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance

Reset 7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk

Tolerance Decay

Full tolerance 3d Half tolerance 7d Baseline ~14d

Patterns are extrapolated from general opioid tolerance behavior and limited user reports. κ‑agonist dysphoria can reduce compulsive redosing for some, but physiological tolerance and dependence can still develop after several consecutive days. Data quality is low; individual variation is high.

Cross-Tolerances

Other opioids (μ‑agonists)

50%

Effects Erowid

Aggregated from 12 Erowid experience reports

Positive Effects 5

Sedation 41.7% 70%

Euphoria 33.3% 70%

Anxiety Suppression 33.3% 70%

Stimulation 25.0% 70%

Empathy 25.0% 70%

Adverse Effects 2

Nausea 41.7% 70%

Confusion 33.3% 70%

Combinations TripSit

Butorphanol's nerd page Pharmacology, chemical data, effect profiles, and more

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