Summary
Caffeine is a a CNS stimulant, and also the most widely used psychoactive substance in the world. It is legal and unregulated in most parts of the world, and is found in many commonly sold products. It has a good safety profile, though regular heavy use can cause physical dependence and contribute to certain medical conditions.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 20-50mg | 50-150mg | 150-500mg | 500mg+ |
| Insufflated | 10-25mg | 25-40mg | 40-80mg | 80mg+ |
| Smoked | 25-75mg | 75-125mg | 125-175mg | 175mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects | Total |
|---|---|---|---|---|---|---|
| Oral | 5-45 min | 10-60 min | 0.5-2 hrs | 2-10 hrs | 2-12 hrs | 90-0 min |
| Insufflated | 0 min | 0 min | 30-60 min | 6-10 hrs | 6-24 hrs | 90-0 min |
| Smoked | 0-6 min | - | 12-18 min | 30-48 min | 2-4 hrs | 90-0 min |
Tolerance
Build-up
develops over 1–2 weeks of daily use
Reset
7–12 days of abstinence
Cross-tolerance
Effects
Positive
- Stimulation
- Physical euphoria
- Bronchodilation
Negative
- Increased heart rate
- Increased blood pressure
- Increased perspiration
- Jitteriness
- Teeth grinding
- Nausea
- Physical agitation
- Uncomfortable bodyload
- Vasoconstriction
- Frequent urination
- Elevated heartrate
- Increase in cognitive abilities
Positive
- Wakefulness
- Focus enhancement
- Motivation enhancement
- Analysis enhancement
- Memory enhancement
- Cognitive euphoria
Negative
- Anxiety
- Irritability
- Panicked thinking
- Cognitive fatigue
- Depression
- Thought deceleration
- Thought acceleration
- Racing thoughts
Positive
- Increased libido
- Tactile enhancement
- Increased Music Appreciation
- Increased Libido
- Increased music appreciation
Negative
- Appetite suppression
- Light sensitivity
- Appetite Suppression
- Dehydration
- Disinhibition