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    Caffeine

    Aliases: Tea, Many, Theine, Coffee, Mateine

    Stimulant Nootropic

    Summary TripSit PsychonautWiki

    Caffeine is a a CNS stimulant, and also the most widely used psychoactive substance in the world. It is legal and unregulated in most parts of the world, and is found in many commonly sold products. It has a good safety profile, though regular heavy use can cause physical dependence and contribute to certain medical conditions.

    Dose Information TheDrug.Wiki TripSit PsychonautWiki

    ROA Light Common Strong Heavy
    Oral 20-50mg 50-150mg 150-500mg 500mg+
    Insufflated 10-25mg 25-40mg 40-80mg 80mg+
    Smoked 25-75mg 75-125mg 125-175mg 175mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit PsychonautWiki

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 5-45 min 10-60 min 0.5-2 hrs 2-10 hrs 2-12 hrs 2.8-13.8 hrs
    Smoked 0-6 min - 12-18 min 30-48 min 2-4 hrs 42-72 min

    Effect Profile

    402 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Validated against 402 Erowid trip reports
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Stimulant 8.8
    Intense+ 9/10

    Strong stimulation, euphoria, focus, and anxiety/jitters

    Stimulation / Energy ×3
    10
    stimulation wakefulness
    Euphoria / Mood Lift ×2
    10
    physical euphoria cognitive euphoria motivation enhancement
    Focus / Productivity ×2
    10
    focus enhancement analysis enhancement memory enhancement motivation enhancement thought acceleration
    ⚠ Anxiety / Jitters ×1
    10
    anxiety jitteriness increased heart rate teeth grinding vasoconstriction
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Caffeine The Drug Users Bible Caffeine
    View methodology →

    Tolerance

    Build-up develops over 1–2 weeks of daily use
    Reset 7–12 days of abstinence

    Tolerance Decay

    Full tolerance 3d Half tolerance 3d Baseline ~10d

    Tolerance to many subjective and cardiovascular effects develops with daily use over days to weeks and decays over about 1–2 weeks of abstinence; withdrawal (headache, sleepiness, irritability) usually peaks within 24–48 hours and resolves within several days. Data are mixed and interindividual variability is high; figures above synthesize experimental and observational reports.

    Cross-Tolerances

    Theophylline
    40%
    Theobromine
    30%

    Effects Erowid

    Aggregated from 402 Erowid experience reports

    Positive Effects 11

    Stimulation 62.7% 70%
    Euphoria 30.3% 70%
    Music Enhancement 22.9% 70%
    Focus Enhancement 22.1% 70%
    Tactile Enhancement 17.4% 70%
    Color Enhancement 16.7% 70%
    Empathy 16.2% 70%
    Body High 9.5% 70%
    Creativity Enhancement 5.2% 70%
    Introspection 4.7% 70%
    Pain Relief 2.2% 70%

    Adverse Effects 13

    Anxiety 37.8% 70%
    Nausea 24.9% 70%
    Confusion 18.9% 70%
    Headache 13.2% 70%
    Increased Heart Rate 9.7% 70%
    Memory Suppression 9.5% 70%
    Sweating 8.2% 70%
    Muscle Tension 6.0% 70%
    Motor Impairment 5.0% 70%
    Pupil Dilation 4.7% 70%
    Psychosis 3.5% 70%
    Appetite Suppression 3.0% 70%
    Seizure 2.0% 70%

    Combinations TripSit

    Pill Identifiers

    3 known pill identifiers on record — view imprints, colors, shapes, and images
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    Caffeine's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki 📖 TripSit 📖 The Drug Users Bible