Clobazam - Substance Search

Summary TheDrug.Wiki TripSit

Clobazam is a unique 1,5-benzodiazepine with preferential α2 subunit binding, resulting in potentially less sedation than classic 1,4-benzodiazepines. FDA-approved for Lennox-Gastaut syndrome; used off-label for anxiety and other seizure types in some countries. The long-acting active metabolite N-desmethylclobazam significantly contributes to effects and extends duration.

Dose Information TheDrug.Wiki TripSit

ROA	Light	Common	Strong	Heavy
Oral	5-10mg	10-15mg	-	15-30mg+

Light Common Strong Heavy

Benzo Equivalence Calculator

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mg

Convert to

20.0 mg Clobazam

=

— mg Diazepam

⚠ These are approximate equivalences for educational and cross-tapering reference. Individual response, tolerance, and half-life differences mean actual equivalence varies. Always consult a healthcare provider for tapering guidance.

Onset, Duration & After-effects TheDrug.Wiki TripSit

ROA	Onset	Comeup	Peak	Offset	After Effects	Total
Oral	30-60 min	60-90 min	1-4 hrs	6-12 hrs	24-24 hrs	8.5-18.5 hrs

Effect Profile

1 reports

Scores (1–10) curated from multiple sources:

Effect keyword matching from PsychonautWiki catalog
Weighted by importance: core (×3), major (×2), minor (×1)

Full methodology

Benzodiazepine 6.7

Strong+ 7/10

Strong anxiolysis and cognitive impairment with moderate euphoria, mild sedation

Anxiolysis ×3

10

anxiolysis anxiety suppression anxiolytic muscle relaxation muscle relaxant emotion suppression

Sedation / Relaxation ×2

5

sedation muscle relaxation

⚠ Motor / Cognitive Impairment ×1

9

motor control loss memory suppression amnesia delusions of sobriety

Euphoria / Mood Lift ×1

6

physical euphoria disinhibition

Based on reports from:

Erowid Experience Reports PsychonautWiki Clobazam

Tolerance

Build-up develops over 1–4 weeks of daily use; hypnotic tolerance faster than anxiolytic tolerance

Reset weeks to months depending on half-life and duration of use; taper recommended

Tolerance Decay

Full tolerance 14d Half tolerance 168d Baseline ~336d

Tolerance to hypnotic/anxiolytic effects tends to develop over weeks of daily use and decays slowly over weeks after cessation; seizure‑protective effects may persist variably. Data are drawn from class‑level evidence and clinical experience; individual variability is high.