Clobazam
Aliases: Onfi, Frisium, Urbanol, Urbanyl, Urbadan
Categories
Summary
Clobazam is a unique 1,5-benzodiazepine with preferential ฮฑ2 subunit binding, resulting in potentially less sedation than classic 1,4-benzodiazepines. FDA-approved for Lennox-Gastaut syndrome; used off-label for anxiety and other seizure types in some countries. The long-acting active metabolite N-desmethylclobazam significantly contributes to effects and extends duration. Tolerance to anticonvulsant effects may develop. Can cause serious skin reactions including Stevens-Johnson syndrome, especially in first 8 weeks.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 5-10mg | 10-15mg | - | 15-30mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects | Total |
|---|---|---|---|---|---|---|
| Oral | 30-60 min | 60-90 min | 1-4 hrs | 6-12 hrs | 24 hrs | 360-0 min |
Tolerance
Build-up
develops over 1โ4 weeks of daily use; hypnotic tolerance faster than anxiolytic tolerance
Reset
weeks to months depending on half-life and duration of use; taper recommended
Cross-tolerance
Effects
Positive
- Anxiolysis
- Muscle relaxation
- Anticonvulsant effects
- Anxiolytic
- Muscle Relaxant
- Physical euphoria
Negative
- Respiratory depression
- Sedation
- Sedative
- Dystaxia
Positive
- Anxiety suppression
Negative
- Cognitive suppression
- Memory suppression
- Motor control loss
- Compulsive redosing
- Thought deceleration
- Emotion suppression
- Amnesia
- Dizziness
- Delusions of sobriety
Positive
Negative
- Disinhibition
- Decreased Libido
- Acuity Suppression
- Visual acuity suppression
- Appetite suppression
- Acuity suppression
- Dulled perception
- Appetite fluctuation
- Hallucinations
- Perception of bodily heaviness