Summary
Clonazepam is a long-acting benzodiazepine with an elimination half-life of 30-40 hours. Abrupt discontinuation after regular use can cause life-threatening withdrawal symptoms including seizures. Tapering over weeks or months under medical supervision is essential. The substance presents paradoxical reactions in some users including increased anxiety, aggression, and disinhibition. Should only be used under medical supervision due to high addiction potential and dangerous withdrawal syndrome.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 0.25-0.5mg | 0.5-1mg | 1-2mg | 2mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects | Total |
|---|---|---|---|---|---|---|
| Oral | 20-60 min | 30-60 min | 2-4 hrs | 3-6 hrs | 8-48 hrs | 480-0 min |
Tolerance
Build-up
develops over 1–4 weeks of daily use; hypnotic tolerance faster than anxiolytic tolerance
Reset
weeks to months depending on half-life and duration of use; taper recommended
Cross-tolerance
Effects
Positive
- Muscle relaxation
- Physical euphoria
- Anxiolytic
- Muscle Relaxant
- Seizure suppression
Negative
- Respiratory depression
- Sedation
- Sedative
- Dystaxia
- Hypnotic
Positive
- Anxiety suppression
Negative
- Motor control loss
- Amnesia
- Emotion suppression
- Thought deceleration
- Compulsive redosing
- Delusions of sobriety
- Dizziness
- Analysis suppression
- Delusions
- Information processing suppression
Positive
Negative
- Disinhibition
- Decreased Libido
- Acuity Suppression
- Visual acuity suppression
- Appetite suppression
- Acuity suppression
- Dulled perception
- Appetite fluctuation
- Hallucinations
- Perception of bodily heaviness