Summary
Clonidine (known by the trade names Catapres, Kapvay, Nexiclon, Clophelin, and others) is a depressant substance of the arylaminoimidazoline class. It is primarily used to treat high blood pressure, but can also be used for a variety of conditions that include attention deficit hyperactivity disorder, anxiety disorders, tic disorders, substance withdrawal, migraine, diarrhea, and certain pain conditions.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 50-75μg | 75-100μg | 100-300μg | 300μg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | After Effects | Total |
|---|---|---|---|---|---|
| Oral | 12-48 min | 60-90 min | 6-8 hrs | 60-0 min | 480-0 min |
Tolerance
Build-up
develops over 1–4 weeks of regular use
Reset
days to weeks depending on duration of use
Effects
Positive
- Stimulation
- Physical euphoria
- Muscle relaxation
- Spontaneous tactile sensations
Negative
- Motor impairment
- Nausea
- Increased heart rate
- Respiratory depression
- Sedation
- Difficulty urinating
Positive
- Reduced anxiety
- Euphoria
- Cognitive euphoria
- Anxiety suppression
Negative
- Thought deceleration
- Anxiety
- Memory suppression
- Compulsive redosing
- Dizziness
- Time distortion
Positive
- Increased libido
- Increased music appreciation
Negative
- Dehydration
- Disinhibition
- Appetite suppression
- Dulled perception
- Internal hallucinations
- Auditory hallucinations
- Drifting
- Auditory distortion