Creatine
Aliases: N-amidinosarcosine, Methylguanidoacetic acid, N-carbamimidoyl-n-methylglycine
Summary
Creatine is a naturally occurring amino acid and one of the most well-researched dietary supplements. While generally considered safe at recommended doses (3-5 g/day maintenance), proper hydration is essential to prevent cramping and gastrointestinal distress. Individuals with pre-existing kidney disease should consult a healthcare provider before use.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 1-5g | 5-10g | 10-20g | 20g+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Stimulant
6.4
Strong
6/10
Strong focus with moderate stimulation, low euphoria and anxiety/jitters
Stimulation / Energy
×3
7
physical stimulation
stimulation
stamina enhancement
Euphoria / Mood Lift
×2
2
motivation enhancement
Focus / Productivity
×2
9
focus enhancement
analysis enhancement
memory enhancement
motivation enhancement
Anxiety / Jitters
×1
2
increased heart rate
Based on reports from:
Tolerance
Build-up
develops over days to weeks of regular use
Reset
3–7 days for acute tolerance; longer for full reset
Tolerance Decay
Full tolerance
1d
Half tolerance
10d
Baseline
~18d
Effects
Positive
- Physical Stimulation
- Stamina Enhancement
- Stimulation
Negative
- Increased heart rate
- Nausea
- Headache
- Ataxia
- Muscle twitching
- Motor impairment
- Sedation
Positive
- Memory Enhancement
- Motivation Enhancement
- Thought Connectivity
- Analysis Enhancement
- Focus Enhancement
- Anxiety Suppression
- Rejuvenation
Negative
- Confusion
- Delirium
- Thought Organization
Positive
- Bodily Control Enhancement
- Tracers
Negative
- Light sensitivity
- Perception Of Bodily Heaviness
- Visual distortions
- Auditory distortions
- Sensations of floating
- Dulled perception
- Appetite suppressant
- Auditory hallucination
Creatine's nerd page
Pharmacology, chemical data, effect profiles, and more
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