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    Cyclobenzaprine Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 3 corroborating sources
    • 1 ROA with full dose ladder
    • duration data present
    • PubChem toxicity data

    Aliases: amrix, apo-cyclobenzaprin, cycoflex, fexmid, flexeril, mk-130, novo-cycloprine

    Summary

    Muscle relaxant and CNS depressant used to relieve skeletal muscle spasms and associated pain in acute musculoskeletal conditions. Sometimes prescribed off-label for treatment of fibromyalgia or as a sleep aid. Has little recreational value alone, but may potentiate some opioids.

    Dose Information TripSit

    ROA Light Common Strong Heavy
    Oral 2-5mg 5-10mg 10-15mg 15mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TripSit

    ROA Onset Peak After Effects Total
    Oral 15-45 min 6-12 hrs 1-6 hrs 6-12 hrs

    Tolerance

    Build-up sedative effects diminish over 1–2 weeks of daily use
    Reset a few days

    Tolerance Decay

    Full tolerance 14d Half tolerance 7d Baseline ~14d

    Tolerance to daytime sedation can develop over several days of repeated use. Given sparse formal data, these values are approximate and based on class inferences and user reports rather than controlled studies.

    Effects Erowid

    Aggregated from 61 Erowid experience reports

    Positive Effects 9

    Sedation 50.8% 70%
    Stimulation 24.6% 70%
    Music Enhancement 23.0% 70%
    Euphoria 19.7% 70%
    Anxiety Suppression 11.5% 70%
    Body High 9.8% 70%
    Tactile Enhancement 9.8% 70%
    Focus Enhancement 6.6% 70%
    Empathy 4.9% 70%

    Adverse Effects 4

    Confusion 9.8% 70%
    Nausea 6.6% 70%
    Headache 6.6% 70%
    Pupil Dilation 4.9% 70%

    Community Trip Reports

    Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.

    Erowid 8 reports 6 neutral 2 cautionary visit
    Intellectual Relaxation neutral exp #53604

    Previous consumed medications/chemicals: MDMA: 2, 4, 8 days ago. Dextroamphetamine: 2 days ago. Phenergan: 75MG 1 day ago. 20 mg of cyclobenzaprine – oral w/ full glass of water at 12:05am saturday (Note I'm writing this while under intoxication, to increase effect and see whether or not verbal(written) structures chan...

    Ronan · Cyclobenzaprine (Flexeril) · 20 mg oral / 10 mg oral
    Motionless neutral exp #51093

    This will be my first experience with cyclobenzaprine. I acquired a few lately and thought I'd give them a shot. I'm an opiate lover at heart, and I've heard they are comparable to low-potency opiates.

    Slandy Danee · Cyclobenzaprine (Flexeril) · 5 mg insufflated / 5 mg oral / 10 mg oral
    Adventures with Flexeril neutral exp #10357

    After noticing a lack of cyclobenzaprine (Flexeril) information, I figured I'd like to submit what I've learned recently. I've only done it a handful of times (say, 10), but I could share my latest trip report. Flexeril comes in 10mg tabs.

    A Kat · Cyclobenzaprine (Flexeril) · 10 mg oral / 10 mg oral
    SOP·O·RIF·IC neutral exp #8462

    NOTE: This report was written as I was going through the experience in order to illustrate what goes on in the mind of a user. As usual I got sort of bored. I’ve been awake for days, only taking a few naps here and there for about an hour each time.

    The Blaze · 20 mg oral / 20 mg oral
    Boring yet Fluffy neutral exp #38284

    I complained to the doctor of severe back pain and tenseness that prevented me from getting adequate sleep, just to see what I might get. I ended up with a prescription for cyclobenzaprine. At the time that I ingested the cyclobenzaprine, I did indeed have a fair bit of muscular pain in my lower and mid-back.

    Grace · repeated oral / repeated smoked / 5.0 mg oral / 5.0 mg oral
    My Journey With 'Cyclone' (Cyclobenzaprine) neutral exp #28304

    After hearing enthusiastic reports from numerous people about the skeletal muscle relaxant cyclobenzaprine, (or Cyclone, as it has been dubbed by those familiar with it within my circle of friends) I decided that it might be worthwhile to try.

    Mr. Hizodge · 50 mg oral
    Unexpected Panic from Small Dose cautionary exp #119122

    I could not find any specific stories online regarding this kind of experience. A few days ago I took a very small dose of cyclobenzaprine and had a major panic attack and derealization episode that lasted about four days.

    Famous Actress · 36 mg oral / 2.5 mg oral / 2 tablets oral / 2.5 mg oral
    Very Pleasant Experience cautionary exp #19560

    I've done Flexiril a couple times, but this will be a quick description of my first time. Ok, first off, I consider this the best prescription drug I've ever consumed, besides Dilaudid (hydromorphone, basically the strongest pain killer you can get (except for the insane stuff you absolutely cannot get a prescription f...

    Pat · 10 mg oral / 1 glass oral / 10 mg oral / 10 mg insufflated
    Bluelight 4 threads 4 neutral visit
    Cyclobenzaprine Flexeril My First Time Wanted Sleep Got Hallucinations neutral

    Yesterday afternoon, I felt bored. I had a ton Adderall that I haven't used so I decided to have two 20mg pills at 2:30 PM to make work more bearable. Now fast foward to 10:30 PM, when I get home from work. I still feel really wired from the Adderall.

    scraped 2026-03-14
    Flexeril First Time Horrible Stuff neutral

    I've read over and over that Flexeril has no recreational use. There were a few reports on Erowid that were positive, and I had a few that had been laying around for months. Being someone who has to try everything once, I crushed 2 of them up, added a little water, and swallowed it down. Total dose was 20 mg.

    scraped 2026-03-14
    Flexril Cyclobenzaprine 10mg Very Experienced Fun Night With Talking Chair neutral

    I have a rather large scipt for Flexril due to a back problem I'd been having for about year. I went to physical therapy and the problem is pretty much gone now and still have a quite a few flex left. I wrote this report several months ago and submitted it to erowid but it was never published.

    scraped 2026-03-14
    Cyclobenzaprine First Time neutral

    My experience with drugs goes back to 8th grade when I started smoking cannabis. Since then, I’ve experimented with various opiates, amphetamines, alcohol, Diphenhydramine, DXM, Psilocybin mushrooms and Salvia.

    scraped 2026-03-14

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