Cyputylone
Aliases: N-cyclohexylmethylone
Summary
Cyputylone is structurally similar to methylone with cyclohexyl substitution at the amine nitrogen. Early user reports highlight marked body-load including bruxism, hypertension, nausea, and diarrhea even at lower doses around 25 mg rectal. Insufflated material produces strong nasal numbness and vasoconstriction but relatively minimal euphoria compared to methylone or eutylone.
Dose Information
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset |
|---|---|---|---|---|
| Oral | 20-40 min | 30-60 min | 30-90 min | 2-4 hrs |
| Insufflated | 5-10 min | 15-30 min | 30-90 min | 2-3 hrs |
| Rectal | 5-10 min | 15-30 min | 30-90 min | 2-4 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Moderate stimulation, sensory enhancement, and euphoria
Strong anxiety/jitters with moderate euphoria and stimulation, low focus
Tolerance
Tolerance Decay
Acute tolerance can develop within a single session, especially with redosing. Anecdotally, partial tolerance may persist for several days, similar to other serotonergic cathinones. Data quality: low/anecdotal.
Cross-Tolerances
Effects
- Stimulation
- Teeth grinding
- Jaw clenching
- Increased heart rate
- Increased blood pressure
- Nausea
- Temperature regulation suppression
- Pupil dilation
- Vasoconstriction
- Difficulty urinating
- Cognitive euphoria
- Wakefulness
- Alertness enhancement
- Euphoria
- Motivation enhancement
- Compulsive redosing
- Anxiety
- Talkativeness
- Time distortion
- Thought acceleration
- Increased music appreciation
- Tactile enhancement
- Increased libido
- Tracers
- Color enhancement
- Dehydration
- Light sensitivity
- Appetite suppression
- Disinhibition
- Spontaneous physical sensations