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    Disclaimer
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.
    ⚠ Benzodiazepines can cause physical dependence with regular use. Withdrawal can be life-threatening. Never combine with opioids or alcohol.

    Deschloroetizolam

    Aliases: Etizolam-2

    Depressant Research-chemical Benzodiazepine

    Summary PsychonautWiki

    Deschloroetizolam is a short-acting psychoactive substance of the thienodiazepine class which has been shown to produce depressant, anxiolytic, sedative, hypnotic, muscle relaxant, anticonvulsant and amnesic effects. Deschloroetizolam, like benzodiazepines, binds to modulatory sites on the GABA receptors. Deschloroetizolam is closely related to etizolam (Etilaam), triazolam (Halcion), and alprazolam (Xanax).

    Dose Information TheDrug.Wiki TripSit PsychonautWiki

    ROA Light Common Strong Heavy
    Oral 2-4mg 4-6mg 6-12mg 12mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit PsychonautWiki

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 15-30 min 30-60 min 3-4 hrs 3-4 hrs 3-6 hrs 6.8-9.5 hrs

    Effect Profile

    4 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Benzodiazepine 8.0
    Intense 8/10

    Strong anxiolysis and euphoria with mild sedation and cognitive impairment

    Anxiolysis ×3
    10
    anxiety suppression anxiolytic muscle relaxation muscle relaxant emotion suppression
    Sedation / Relaxation ×2
    5
    sedation muscle relaxation
    ⚠ Motor / Cognitive Impairment ×1
    4
    amnesia delusions of sobriety
    Euphoria / Mood Lift ×1
    10
    cognitive euphoria physical euphoria disinhibition
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Deschloroetizolam
    View methodology →

    Tolerance

    Build-up develops over 1–4 weeks of daily use; hypnotic tolerance faster than anxiolytic tolerance
    Reset weeks to months depending on half-life and duration of use; taper recommended

    Tolerance Decay

    Full tolerance 7d Half tolerance 14d Baseline ~30d

    Tolerance to sedation/anxiolysis builds within days of regular use and decays slowly over weeks; figures are heuristic and derived from benzodiazepine class data and community experience rather than DCE-specific trials.

    Cross-Tolerances

    Benzodiazepines
    90%
    Z-drugs (zolpidem, zopiclone, etc.)
    60%

    Effects Erowid

    Aggregated from 4 Erowid experience reports

    Positive Effects 1

    Anxiety Suppression 75.0% 70%

    Adverse Effects 0

    Combinations TripSit

    Deschloroetizolam's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki