Desomorphine - Substance Search

Summary TheDrug.Wiki Erowid PsychonautWiki

Desomorphine (also known as Dihydrodesoxymorphine) is an opioid substance of the morphinan chemical class that produces analgesic, muscle-relaxing, sedative, and euphoric effects when administered. It is a structural analog of morphine and the psychoactive component of the mixture known as Krokodil (also known as Crocodile, Krok, or Croc). Developed by Roche in the 1930s, desomorphine first saw use in Switzerland under the trade name Permonid.

Dose Information TheDrug.Wiki PsychonautWiki

ROA	Light	Common	Strong	Heavy
Oral	10-15mg	15-20mg	20-30mg	30mg+

Light Common Strong Heavy

Onset, Duration & After-effects TheDrug.Wiki PsychonautWiki

ROA	Onset	Comeup	Peak	Offset	After Effects
Oral	10-20 min	-	0.5-2 hrs	1-2 hrs	6-12 hrs
Intravenous	1 min	2-5 min	30-90 min	1-2 hrs	6-12 hrs
Insufflated	5-10 min	10-20 min	0.5-2 hrs	1-2 hrs	6-12 hrs

Effect Profile

Scores (1–10) curated from multiple sources:

Effect keyword matching from PsychonautWiki catalog
Weighted by importance: core (×3), major (×2), minor (×1)

Full methodology

Opioid 6.6

Strong+ 7/10

Strong euphoria with moderate itching/nausea, mild pain relief and sedation

Euphoria / Warmth ×3

10

physical euphoria cognitive euphoria euphoria mood lift

Analgesia ×2

4

analgesia

Sedation / Relaxation ×1

4

sedation dream potentiation

⚠ Itching / Nausea ×1

6

nausea constipation

Based on reports from:

Erowid Experience Reports PsychonautWiki Desomorphine

Tolerance

Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance

Reset 7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk

Tolerance Decay

Full tolerance 3d Half tolerance 5d Baseline ~21d

Pattern inferred from opioid class data and community reports: fast tolerance buildup with daily/frequent redosing; partial reversal over 1–2 weeks; near‑baseline in ~3–4 weeks for many, but longer after heavy/chronic use. Data quality limited; individual variability is high.