I injected it into my left arm a few days ago. My entire arm actually FELL OFF It rotted so bad, I had to rush to the hospital but on the way over to the hospital it fell off!!!! I got to the ER and I walked in carrying my left arm.
Desomorphine
Well-documented
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 5 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 29 combo interactions documented
- toxicity data (PsychonautWiki)
- classified Research-chemical
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 5 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 29 combo interactions documented
- toxicity data (PsychonautWiki)
- classified Research-chemical
Aliases: Krok, Croc, Krokodil, Permonid, Crocodile
Summary
Desomorphine (also known as Dihydrodesoxymorphine) is an opioid substance of the morphinan chemical class that produces analgesic, muscle-relaxing, sedative, and euphoric effects when administered. It is a structural analog of morphine and the psychoactive component of the mixture known as Krokodil (also known as Crocodile, Krok, or Croc). Developed by Roche in the 1930s, desomorphine first saw use in Switzerland under the trade name Permonid.
Dose Information
Dose basis. Desomorphine is roughly 8-10 times the potency of morphine. The oral figures above are community-derived, not clinical. An earlier version of this page served morphineβs ladder verbatim β doses roughly ten times too high β corrected 7 August 2026. Illicitly produced desomorphine ("krokodil") additionally carries severe tissue injury from synthesis residues that has nothing to do with the dose.
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 2-5mg | 5-10mg | 10-15mg | 15mg+ |
Light
Common
Strong
Heavy
Sources
Oral
Dose ladder — Drugs.WikiOnset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 10-20 min | - | 0.5-2 hrs | 1-2 hrs | 1.67-4.33 hrs |
| Intravenous | 36 sec | 2-5 min | 30-90 min | 1-2 hrs | 1.54-3.59 hrs |
| Insufflated | 5-10 min | 10-20 min | 0.5-2 hrs | 1-2 hrs | 1.75-4.5 hrs |
Effect Profile
Scores (0–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Opioid
6.6
Strong+
7/10
Strong euphoria with moderate itching/nausea, mild pain relief and sedation
Euphoria / Warmth
×3
10
physical euphoria
cognitive euphoria
euphoria
mood lift
Analgesia
×2
4
analgesia
Sedation / Relaxation
×1
4
sedation
dream potentiation
Itching / Nausea
×1
6
nausea
constipation
Based on reports from:
Tolerance
Build-up
develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
Reset
Falls quickly once you stop, at a rate you can't judge. After any break, treat your tolerance as gone.
No tolerance chart. Our decay curves for opioids were estimates, and a curve can make tolerance look longer-lasting than it is, which is the dangerous direction.
Opioid tolerance drops fast when you stop, and even a few days off can be enough, so a dose that used to be normal can now stop your breathing. Overdose deaths rise sharply after prison, detox or leaving treatment, and tolerance also falls during a hospital stay. After any break, start with a much smaller amount, try a test dose first, don't use alone, and keep naloxone within reach. Alcohol, benzodiazepines, gabapentinoids and other sedatives make an opioid overdose much more likely.
Sources: FRANK: heroin Β· National Harm Reduction Coalition Β· WHO: opioid overdose Β· Merrall et al. 2010 Β· Binswanger et al. 2007 Β· Strang et al. 2003 Β· FDA 2019: gabapentinoids and breathing
Cross-Tolerances
All ΞΌβopioid agonists (morphine, heroin, hydromorphone, fentanyl family)
Effects
Effect glossary — · full glossary
Positive
Negative
Positive
Negative
Negative
Combinations
Cross-Check Desomorphine with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, Bluelight, and Dose.wiki. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.
Bluelight 1 thread 1 cautionary visit
Desomorphine's nerd page
Pharmacology, chemical data, effect profiles, and more
→
Helpful Links
Add missing routes to PsychonautWiki Journal
The PsychonautWiki Journal app already has Desomorphine, but its built-in entry only covers Oral. Here are the other routes we have data for. You can't edit a built-in substance, but you can add a Custom Unit for any of these routes to log it.
⬇ Download import file
Import this file as custom substances
and you get "Desomorphine (Substance Search)" with every
route's full dose ladder and timeline, no typing. Works on iOS and
Android (v15+); the format is confirmed by the app's
developer. The manual values below work for older
versions.
Duration (reference)
Desomorphine: routes the PsychonautWiki Journal app is missing Source: SubstanceSearch (substancesearch.com) Intravenous duration: onset 36s Β· come-up 2-5m Β· peak 0.5-1.5h Β· offset 1-2h Β· total 1.54-3.59h Β· after-effects 6-12h Insufflated duration: onset 5-10m Β· come-up 10-20m Β· peak 0.5-2h Β· offset 1-2h Β· total 1.75-4.5h Β· after-effects 6-12h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Ranges are harm-reduction guidance, not a prescription.
Report an issue or suggest an edit
Spotted incorrect or dangerous information, have a correction, a new study, or a useful addition for Desomorphine? Let us know. Reports are reviewed by moderators — this is not posted publicly.