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    ⚠ Opioids carry significant risk of respiratory depression, physical dependence, and fatal overdose. Never combine with other depressants.

    Dextropropoxyphene

    Aliases: Darvon, Capadex, Darvocet, Di-gesic, Co-proxamol, coproxamol

    Depressant Opioid

    Summary TheDrug.Wiki TripSit PsychonautWiki

    Dextropropoxyphene (also known as Propoxyphene and Darvon) is a synthetic opioid of the phenylpropylamine chemical class. Like other substances in its class, particularly tapentadol and tramadol, it produces mild euphoric, analgesic, sedative and antitussive effects when administered (typically orally, but sometimes intravenous or rectally). Notably, it is reported to produce significantly less euphoria in comparison to other opioids.

    Dose Information TheDrug.Wiki TripSit PsychonautWiki

    ROA Light Common Strong Heavy
    Oral 30-65mg 65-100mg 100-200mg 200mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit PsychonautWiki

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 20-30 min 30-60 min 1-4 hrs 2-4 hrs 1-6 hrs 3.83-9.5 hrs

    Effect Profile

    2 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Opioid 6.6
    Strong+ 7/10

    Strong euphoria with moderate itching/nausea, mild pain relief and sedation

    Euphoria / Warmth ×3
    10
    physical euphoria cognitive euphoria euphoria
    Analgesia ×2
    4
    pain relief
    Sedation / Relaxation ×1
    4
    sedation dream potentiation
    ⚠ Itching / Nausea ×1
    6
    nausea constipation
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Dextropropoxyphene
    View methodology →

    Tolerance

    Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
    Reset 7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk

    Tolerance Decay

    Full tolerance 1d Half tolerance 21d Baseline ~35d

    Effects TheDrug.Wiki

    Positive
    • Pain Relief
    • Physical Euphoria
    • Cough Suppression
    • Physical euphoria
    Negative
    • Respiratory Depression
    • Nausea
    Neutral
    • Sedation
    • Itchiness
    • Pupil Constriction
    • Difficulty Urinating
    Positive
    • Cognitive Euphoria
    • Anxiety Suppression
    • Dream Potentiation
    • Anxiety suppression
    • Cognitive euphoria
    • Euphoria
    Negative
    • Constipation
    • Dizziness
    • Confusion
    • Compulsive Redosing
    Positive
    • Increased music appreciation
    Negative
    • Decreased Libido
    • Appetite Suppression
    • Appetite suppression
    • Double vision
    • Orgasm Suppression
    • Acuity Suppression
    • Dehydration
    Neutral
    • Dulled perception
    • Internal hallucination

    Combinations TripSit

    Pill Identifiers

    1 known pill identifiers on record — view imprints, colors, shapes, and images
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    Dextropropoxyphene's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    💊 Pill Identifier 📘 Experience Reports 📖 TheDrug.Wiki 📖 TripSit 📖 PsychonautWiki