I have used Darvon many times, the first being the best, so I'll share it with you. It was early afternoon, around 1:00, when my older brother asked me if I wanted to take some darvon with him. I didn't know what it was so I was sorta cautious about it. He told me it was a pain killer similar to Vicodin.
Dextropropoxyphene
Well-documented
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 5 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 19 combo interactions documented
- toxicity data (PsychonautWiki, PubChem)
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 5 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 19 combo interactions documented
- toxicity data (PsychonautWiki, PubChem)
Aliases: Darvon, Capadex, Darvocet, Di-gesic, Co-proxamol, coproxamol
Summary
Dextropropoxyphene (also known as Propoxyphene and Darvon) is a synthetic opioid of the phenylpropylamine chemical class. Like other substances in its class, particularly tapentadol and tramadol, it produces mild euphoric, analgesic, sedative and antitussive effects when administered (typically orally, but sometimes intravenous or rectally). Notably, it is reported to produce significantly less euphoria in comparison to other opioids.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 30-65mg | 65-100mg | 100-200mg | 200mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 20-30 min | 30-60 min | 1-4 hrs | 2-4 hrs | 3.83-9.5 hrs |
Effect Profile
2 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Opioid
6.1
Strong
6/10
Strong euphoria with moderate itching/nausea, mild pain relief and sedation
Euphoria / Warmth
×3
9
physical euphoria
cognitive euphoria
euphoria
Analgesia
×2
4
pain relief
Sedation / Relaxation
×1
4
sedation
dream potentiation
Itching / Nausea
×1
6
nausea
constipation
Based on reports from:
Import into PsychonautWiki Journal
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Ranges are harm-reduction guidance, not a prescription.
Tolerance
Build-up
develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
Reset
7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk
Tolerance Decay
Full tolerance
1d
Half tolerance
21d
Baseline
~35d
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Effects
Positive
- Pain Relief
- Physical Euphoria
- Cough Suppression
Negative
- Respiratory Depression
- Nausea
- Sedation
- Itchiness
- Pupil Constriction
- Difficulty Urinating
Positive
- Cognitive Euphoria
- Anxiety Suppression
- Dream Potentiation
- Euphoria
Negative
- Constipation
- Dizziness
- Confusion
- Compulsive Redosing
Positive
- Increased music appreciation
Negative
- Decreased Libido
- Appetite Suppression
- Double vision
- Orgasm Suppression
- Acuity Suppression
- Dehydration
- Dulled perception
- Internal hallucination
Combinations
Cross-Check Dextropropoxyphene with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.
Erowid 1 report 1 positive visit
Bluelight 1 thread 1 neutral visit
Primer: I have a high tolerance to opiates and also am a heroin addict on and off. Anyway, it was a Saturday morning and I had 10 Vicodens(Hydrocodone) 7.5/350 APAP's and 9 Darvons(Propoxyphene) 65/350 APAP's. Both are relatively weak synthetic opiods.
Pill Identifiers
1
known pill identifiers on record — view imprints, colors, shapes, and images
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Dextropropoxyphene's nerd page
Pharmacology, chemical data, effect profiles, and more
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Helpful Links
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