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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    DMHA Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 2 corroborating sources
    • 2 ROAs with full dose ladders
    • duration data present
    • classified Research-chemical
    • dose data not in PW/TripSit (unverifiable)

    Aliases: Amidrine, Vaporpac, Octodrine, 2-aminoisoheptane, 1,5-dimethylhexylamine

    Stimulant Research-chemical

    Summary dose.wiki

    DMHA is a synthetic sympathomimetic stimulant originally developed as a nasal decongestant in the 1940s-1950s. The FDA considers DMHA an unsafe food additive and has issued warning letters to supplement manufacturers. It is banned by WADA for athletic competition and is illegal in several countries including Australia, Canada, and parts of the EU.

    Dose Information dose.wiki Drugs.Wiki

    Dose basis. Dose data primarily come from user reports and supplement labels, not controlled clinical studies; salt form (freebase vs HCl) and product purity vary widely. Use an accurate mg scale; avoid combining with proprietary blends that include multiple stimulants. Anecdotal reports only; higher risk of nasal irritation and local vasoconstriction. Oral use is generally lower-risk than intranasal for this compound. (Dose figures and this note are from Drugs.Wiki.)

    ROA Light Common Strong Heavy
    Oral 75-100mg 100-150mg 150-200mg 200mg+
    Insufflated 50-75mg 75-100mg 100-150mg 150mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects dose.wiki Drugs.Wiki

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 20-40 min 30-60 min 1-2 hrs 1-2 hrs 2-4 hrs 2.83-5.67 hrs
    Insufflated 5-15 min 15-30 min 1-2 hrs 1-2 hrs 1-3 hrs 2.33-4.75 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Stimulant 5.6
    Strong 6/10

    Strong focus and anxiety/jitters with mild stimulation and euphoria

    Stimulation / Energy ×3
    5
    stimulation increased energy
    Euphoria / Mood Lift ×2
    5
    euphoria motivation enhancement
    Focus / Productivity ×2
    10
    enhanced focus focus enhancement cognitive enhancement motivation enhancement
    ⚠ Anxiety / Jitters ×1
    10
    anxiety restlessness increased heart rate teeth grinding tachycardia vasoconstriction
    View methodology →

    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track DMHA there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "DMHA (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    DMHA
    Unit
    mg
    Description 
    DMHA
Source: SubstanceSearch (substancesearch.com)

Oral dose (mg): threshold 50 · light 75-100 · common 100-150 · strong 150-200 · heavy 200+
Insufflated dose (mg): threshold 25 · light 50-75 · common 75-100 · strong 100-150 · heavy 150+

Oral duration: onset 20-40m · come-up 0.5-1h · peak 1-2h · offset 1-2h · total 2.83-5.67h · after-effects 2-4h
Insufflated duration: onset 5-15m · come-up 15-30m · peak 1-2h · offset 1-2h · total 2.33-4.75h · after-effects 1-3h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 125 mg (Oral).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.

    Tolerance

    Build-up develops over days to weeks of regular use
    Reset 3–7 days for acute tolerance; longer for full reset

    Tolerance Decay

    Full tolerance 14d Half tolerance 3d Baseline ~18d

    Estimates reflect stimulant-class tolerance patterns inferred from user reports; high uncertainty.

    Cross-Tolerances

    DMAA
    60%
    Caffeine
    20%

    Effects dose.wiki

    Positive
    • Stimulation
    • Increased energy
    Negative
    • Increased heart rate
    • Increased blood pressure
    • Vasoconstriction
    • Restlessness
    • Increased perspiration
    • Teeth grinding
    • Tachycardia
    • Temperature regulation suppression
    Positive
    • Enhanced focus
    • Cognitive enhancement
    • Motivation enhancement
    • Euphoria
    • Focus enhancement
    • Increased sociability
    Negative
    • Anxiety
    • Irritability
    • Cognitive fatigue
    Neutral
    • Time distortion
    Positive
    • Increased libido
    • Color enhancement
    • Increased music appreciation
    • Tactile enhancement
    Negative
    • Appetite suppression
    • Light sensitivity
    • Dehydration
    • Disinhibition
    Neutral
    • Dulled perception
    • Drifting
    DMHA's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📘 Experience Reports 📖 dose.wiki 📖 PsychonautWiki