I was about 15 if I recall correctly I was on probation for getting caught with xanax at school so I could no longer smoke weed. I loved weed but didn't want to get caught up with my probation officer so I began to figure ways to 'have fun' if you know what I mean on probation without having to worry about dropping dir...
DOC
Well-documented
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 5 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 20 combo interactions documented
- PubChem toxicity data
- classified Research-chemical
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 5 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 20 combo interactions documented
- PubChem toxicity data
- classified Research-chemical
Summary
DOC is an extremely potent and long-lasting psychedelic amphetamine with a steep dose-response curve. Active at sub-milligram doses with effects lasting 14-20 hours, it poses significant risks of overdose and prolonged difficult experiences. Commonly misrepresented as LSD on blotter paper.
Perspectives
“There is little I can say about DOC that hasnβt been said already. I am grateful that I got to experience this, grateful for the humor and grateful for the intensity and testing the limits of my endurance. DOC for me at this dose was immense, intense and domineering.”
“I was hit with a slightly light head; the effects were quite real. I was disconnected, and somehow spacey, but this was a favorable spacey which was kind of fun. Somewhere at about the sixth hour I realized that I was beginning to drop off a bit, but six hours later yet, there was still a lot of memory. This is a long thing.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 1-2mg | 2-4mg | 4-6mg | 6mg+ |
| Insufflated | 0.25-1mg | 1-2mg | 2-3.5mg | 3.5mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 0.75-2 hrs | 1-2.5 hrs | 3.5-6 hrs | 3-6 hrs | 10-20 hrs |
| Insufflated | 0-6 min | 12-30 min | 2-6 hrs | 2-8 hrs | 10-20 hrs |
Effect Profile
148 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Validated against 83 Erowid trip reports
- Weighted by importance: core (×3), major (×2), minor (×1)
Psychedelic
8.1
Intense
8/10
Strong visuals, body load, headspace, and auditory effects
Visual Intensity
×3
10
color enhancement
drifting
tracers
visual enhancement
pattern recognition enhancement
brightened colour
Headspace Depth
×3
9
thought connectivity
time distortion
confusion
Auditory Effects
×1
8
Body Load / Somatic Effects
×1
10
vasoconstriction
nausea
temperature regulation suppression
muscle tension
increased heart rate
Stimulant
8.0
Intense
8/10
Strong stimulation, euphoria, and anxiety/jitters with moderate focus
Stimulation / Energy
×3
10
stimulation
wakefulness
Euphoria / Mood Lift
×2
10
physical euphoria
cognitive euphoria
euphoria
Focus / Productivity
×2
7
analysis enhancement
Anxiety / Jitters
×1
10
anxiety
restlessness
increased heart rate
vasoconstriction
muscle tension
Based on reports from:
Tolerance
Build-up
develops rapidly; very long duration provides natural spacing
Reset
7β14 days for baseline
Tolerance Decay
Full tolerance
1d
Half tolerance
7d
Baseline
~14d
Acute tolerance: develops within a single session β the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Tolerance to DOC (and classic psychedelics) rises sharply after an experience and then decays over about 1β2 weeks; model and ratios are heuristic, inferred from user reports, not measured pharmacology.
Effects
Aggregated from 83 Erowid and 65 Bluelight experience reports
Positive Effects 69
Stimulation
57.1%
85%
Visual Distortions
56.4%
84%
Color Enhancement
54.9%
85%
Music Enhancement
40.6%
89%
Euphoria
39.9%
88%
Closed-Eye Visuals
32.3%
87%
Awe
30.0%
80%
Empathy
28.6%
80%
Visual Trails
28.0%
84%
Thought Acceleration
28.0%
81%
Sedation
27.8%
85%
Open-Eye Visuals
25.6%
89%
Introspection
24.1%
80%
Body High
24.1%
84%
Auditory Effects
22.5%
82%
Tactile Enhancement
22.5%
90%
Morphing
22.0%
84%
Focus Enhancement
21.8%
80%
Geometric Imagery
18.0%
85%
Joy
16.0%
86%
Adverse Effects 48
Anxiety
45.1%
76%
Confusion
30.1%
82%
Body Load
30.0%
77%
Nausea
26.3%
80%
Muscle Tension
21.8%
75%
Dissociation
13.5%
70%
Fear
12.0%
81%
Insomnia
12.0%
82%
Psychosis
10.8%
70%
Memory Suppression
10.6%
80%
Thought Disorganization
10.0%
78%
Headache
9.0%
78%
Jaw Clenching
9.0%
82%
Increased Heart Rate
8.4%
70%
Dysphoria
8.0%
78%
Depersonalization
8.0%
76%
Vomiting
8.0%
88%
Sweating
6.0%
85%
Frequent Urination
6.0%
80%
Dry Mouth
6.0%
77%
Combinations
Cross-Check DOC with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.
Erowid 8 reports 2 positive 4 neutral 2 cautionary visit
DOC Warning I started using DOC slightly over a year from now. Before DOC I used a lot of different hallucinogens, mushrooms, dmt, lsd, peyote. At the time I was using a lot of MDMA; after doing DOC a couple of times, I stopped using MD. ....Was using DOC once a week at high doses [6-12mg], redosing later again.
DOC Report Β Analysis of Evil in the World Substance: DOC HCl Β 5 mg (oral, sublingual) I had long been interested in the DOx series after becoming familiar with the NBOMe series.
My experiences with psychedelics began at 17, with LSA, mushrooms and then eventually LSD-25. By 2009, the genuine LSD-25 had all but vanished from my city, and blotter acid began to shift into the focus of grey-market psychedelic phenethylamines.
'Bitter amphetamine mixture is floating so free. Mixed to precision I swish it around in my mouth 'Til it filters through membranes and saturates me. Waiting and waiting and waiting it gathers its speed And finally crosses the threshold, my soul's floating free.
Substance: DOC (2,5-Dimethoxy-4-Chloroamphetamine) Dose: 6 Milligrams / 4 mg powder in clear capsule. 2 mg blotter. Setting: My Apartment & Area of Town. Date: Saturday, October 22, 2005.
I'd heard some good things about DOC, and had been interested in trying it. I consider myself an experienced user of entheogens and other mind-expanding substances, and have had only positive experiences previously. Before now, I have used: Psilocybin mushrooms, LSD, Salvia Divinorum, Ecstasy, 2C-I, and 5MEO-DMT.
I am choosing to write this trip report, after watching a very close friend of mine had an extremely negative reaction to the drug 2,5-dimethoxy-4-chloroamphetamine (AKA DOC).
Bluelight 8 threads 3 positive 3 neutral 2 cautionary visit
I dedicate this report to the memory of Ann Shulgin. For those of us who seek to document the wide wonderful world of psychedelics, you are a giant upon whose shoulders we stand, and we all owe you our eternal gratitude. This is a long one. It was a long experience.
And amazing day, and night β Background info. 21 year old male, in decent shape. Good mindset. Done a lot of reading and have a full 24 hours set aside. 2:00 We each take 3mg of DOC orally. 2:40 Some first alerts. Too soon to tell if im off baseline yet. 3:00 Off baseline for sure. mabye some visual distortion also.
I decided I would take 1.5mg of DOC -- which in my experience is visually equivilant to about 80ug - 100ug of LSD. Except the visuals are different than with LSD. LSD makes everything look more magical, and the headspace goes along with it. DOC makes everything more beautiful and colorful. That is, at a 1.5mg dose.
not sure if this is the proper place for a trip report (and i should know as ive been emerged in this thread for the past week and the old ones) but anyway skip until *** TrIP REPORT *** part but introduction ill put here. drug history , this is my very 1st research chemical.
This was my first experience knowingly taking an identified psychedelic in the DOx family. For this reason I feel that I should give a little extra background information here, compared to all of my other reports that I have been writing about tryptamines.
"Bitter amphetamine mixture is floating so free. Mixed to precision I swish it around in my mouth 'Til it filters through membranes and saturates me. Waiting and waiting and waiting it gathers its speed And finally crosses the threshold; my soul's floating free.
( DOC/1.5mgs) β Beginner - Donβt take this shit and then go to work (Warning: TL;DR) Now that this substance is making the rounds in a big way, I thought I would share an interesting experience I had with it β in fact, my first experience with DOC.
before you read my trip report, I need to inform you that i did a LOT of LSD two days prior, so because of the cross tolerance I'm not experiencing the effects to their true potential. I did way more than the normal dosage. I do not recommend ANYONE to take more than 4mg their first time, i ended up taking 8mg total.
Bluelight Reference Guide
β Official β The Big & Dandy DOC Thread - Third opinion
Welcome to the Big and Dandy DOC Thread (Part 3) DOC: 4-chloro-2,5-dimethoxyamphetamine Previous B&Ds: Previous Big and Dandy DOC Thread (Part 2) Previouser Big and Dandy DOC Thread (Part 1) Old and Overgrown DOC Thread External Information Links: Erowid DOC Vault (experience reports) PIHKAL Entry for DOC Wikipedia ent...
Read full thread on Bluelight βPiHKAL / TiHKAL
PiHKAL #64: DOC
“I was hit with a slightly light head; the effects were quite real. I was disconnected, and somehow spacey, but this was a favorable spacey which was kind of fun. Somewhere at about the sixth hour I realized that I was beginning to drop off a bit, but six hours later yet, there was still a lot of memory. This is a long thing.”
DOC's nerd page
Pharmacology, chemical data, effect profiles, and more
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Helpful Links
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