T0:00- Dose taken. Feeling a bit anxious over the purported body load from this drug. I have prepared for myself a very intensely flavored brew of lemon extract and fresh ginger. This was done following a claim that Ξ²-pinene could be found in lemon extract and in fresh ginger.
Escaline
Well-documented
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 5 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 18 combo interactions documented
- PubChem toxicity data
- classified Research-chemical
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 5 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 18 combo interactions documented
- PubChem toxicity data
- classified Research-chemical
Aliases: E
Summary
Escaline is a research chemical with very limited human use history and no formal toxicology studies. It is a Schedule I controlled substance in the United States (DEA #7930), and also controlled in Germany, Japan, Sweden, Switzerland, and the UK. In comparison to mescaline, escaline is approximately 5-8 times more potent but produces significantly more intense negative physical side effects, less insightful cognitive effects, and less complex visual effects.
Perspectives
“This drug was better than I had expected it to be, but still was not very much. It seems to light a fire in my mind, generating improved and accelerated cognition, leaving the dynamo of the brain feeling burnt out afterwards. Sensory effects are minor.”
“This is a powerful and complex intoxicantβI could not have coordinated any rational muscular activity. I could not walk; I could not tie my shoe-laces. There is analgesia and an incoordination that I cannot shake. My menstrual flow started a bit ahead of time, but it was light.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 30-50mg | 50-100mg | 100-150mg | 150mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 1-2 hrs | 30-60 min | 5-6 hrs | 2-4 hrs | 8-12 hrs |
Effect Profile
2 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Psychedelic
8.8
Intense+
9/10
Strong visuals, headspace, auditory effects, and body load
Visual Intensity
×3
10
external hallucinations
internal hallucinations
autonomous entities
colour enhancement
drifting
tracers
+6 more
Headspace Depth
×3
10
conceptual thinking
thought connectivity
emotion enhancement
perspective alterations
personal bias suppression
delusions
+3 more
Auditory Effects
×1
10
auditory distortion
auditory enhancement
auditory hallucinations
Body Load / Somatic Effects
×1
10
vasoconstriction
physical discomfort
nausea
muscle tension
muscle spasms
increased heart rate
Tolerance
Build-up
develops rapidly after a single use (serotonergic psychedelic)
Reset
7β14 days for baseline
Tolerance Decay
Full tolerance
1h
Half tolerance
10d
Baseline
~14d
Acute tolerance: develops within a single session β the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Effects
Positive
- Stimulation
- Mental/physical stimulation
- Spontaneous tactile sensations
Negative
- Pupil Dilation
- Increased Heart Rate
- Muscle Tension
- Vasoconstriction
- Physical Discomfort
- Restlessness
- Sweating/chills
- Insomnia
- Muscle spasms
- Nausea
- Temperature Dysregulation
- Decreased appetite
Positive
- Thought Connectivity
- Novelty Enhancement
- Conceptual Thinking
- Immersion Enhancement
- Increased Sense Of Humor
- Mindfulness
- Wakefulness
- Euphoria
- Empathy
- Insight
- Emotion enhancement
Negative
- Memory Suppression
- Confusion
- Delusions
- Thought disorganization
- Thought loops
- Thought Acceleration
- Time Distortion
- Personal Bias Suppression
- Change in perception
- Ego softening
- Perspective alterations
Positive
- Enhanced Color
- Increased Music Appreciation
- Tracers
- Colour Shifting
- Brightened colour
- Enhanced tactile sensation
- Acuity enhancement
- Auditory enhancement
- Bodily control enhancement
- Colour enhancement
- Pattern recognition enhancement
- Tactile enhancement
- Drifting
- After Images
- Symmetrical Texture Repetition
- Scenery Slicing
- Closed/Open eye visuals
- Auditory distortion
- Auditory hallucinations
- Autonomous entities
- External hallucinations
- Internal hallucinations
Combinations
Cross-Check Escaline with another substanceTrip Reports
Community Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.
Erowid 2 reports 2 neutral visit
[This report originally appeared as a typewritten page pasted into Book 3, page 365 of the Shulgin Lab Books.] Experiment: Escaline, 40 mg for EAM and 60 mg for CM 7/4/80 Procedure: The materials were ingested at 12:30 PM two hours after a light breakfast.
Bluelight 3 threads 3 neutral visit
Age: 21 Weight: 120 lbs Dosage: 100 mg oral in gel cap Setting: My apartment T0:00- Dose taken. Feeling a bit anxious over the purported body load from this drug. I have prepared for myself a very intensely flavored brew of lemon extract and fresh ginger.
50 mg This report will be quite short because of the following reasons. I don't usually write reports and the experience was somewhat mild, so I don't really have too much interesting stuff to tell. I also didn't bother to take detailed notes.
Okay i am just coming down off of a 60mg dose of this stuff, i also did 10mg sublingually which didn't seem to make a difference in onset at least. +0.00: feel really happy, excited and ready to trip! Dose 60mg capsule and 10mg under tongue.
Bluelight Reference Guide
The Big & Dandy Escaline Thread
I'm considering trying this stuff in the next few weeks. Does anyone have experience with escaline? How similar is it to mescaline? I love mescaline, but it's such a pain to extract. I would love to find something similar that's easier to acquire.
Read full thread on Bluelight βPiHKAL / TiHKAL
PiHKAL #72: E
“This is a powerful and complex intoxicantβI could not have coordinated any rational muscular activity. I could not walk; I could not tie my shoe-laces. There is analgesia and an incoordination that I cannot shake. My menstrual flow started a bit ahead of time, but it was light.”
Escaline's nerd page
Pharmacology, chemical data, effect profiles, and more
→
Helpful Links
Report an issue or suggest an edit
Spotted incorrect or dangerous information, have a correction, a new study, or a useful addition for Escaline? Let us know. Reports are reviewed by moderators — this is not posted publicly.