T0:00- Dose taken. Feeling a bit anxious over the purported body load from this drug. I have prepared for myself a very intensely flavored brew of lemon extract and fresh ginger. This was done following a claim that Ξ²-pinene could be found in lemon extract and in fresh ginger.
Escaline
Well-documented
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 5 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 18 combo interactions documented
- toxicity data (PsychonautWiki)
- classified Research-chemical
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 5 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 18 combo interactions documented
- toxicity data (PsychonautWiki)
- classified Research-chemical
Aliases: E
Summary
Escaline is a research chemical with very limited human use history and no formal toxicology studies. It is a Schedule I controlled substance in the United States (DEA #7930), and also controlled in Germany, Japan, Sweden, Switzerland, and the UK. In comparison to mescaline, escaline is approximately 5-8 times more potent but produces significantly more intense negative physical side effects, less insightful cognitive effects, and less complex visual effects.
Perspectives
“This drug was better than I had expected it to be, but still was not very much. It, like some other phenethylamines, seems to light a fire in my mind, generating improved and accelerated cognition, leaving the dynamo of the brain feeling burnt out afterwards.”
“This is a powerful and complex intoxicantβI could not have coordinated any rational muscular activity. I could not walk; I could not tie my shoe-laces. There is analgesia and an incoordination that I cannot shake. My menstrual flow started a bit ahead of time, but it was light.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 30-50mg | 50-100mg | 100-150mg | 150mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 1-2 hrs | 30-60 min | 5-6 hrs | 2-4 hrs | 8-12 hrs |
Effect Profile
2 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Psychedelic
8.8
Intense+
9/10
Strong visuals, headspace, auditory effects, and body load
Visual Intensity
×3
10
external hallucinations
internal hallucinations
autonomous entities
colour enhancement
drifting
tracers
+6 more
Headspace Depth
×3
10
conceptual thinking
thought connectivity
emotion enhancement
perspective alterations
personal bias suppression
delusions
+3 more
Auditory Effects
×1
10
auditory distortion
auditory enhancement
auditory hallucinations
Body Load / Somatic Effects
×1
10
vasoconstriction
physical discomfort
nausea
muscle tension
muscle spasms
increased heart rate
Import into PsychonautWiki Journal
The PsychonautWiki Journal app includes Escaline, but its built-in data can be thinner than ours. Importing this file adds a separate "Escaline (Substance Search)" custom substance with our dose ranges, durations and tolerance, so you can log against whichever you prefer.
⬇ Download import file
Import this file as custom substances
and you get "Escaline (Substance Search)" with every
route's full dose ladder and timeline, no typing. Works on iOS and
Android (v15+); the format is confirmed by the app's
developer.
Ranges are harm-reduction guidance, not a prescription.
Tolerance
Build-up
develops rapidly after a single use
Reset
7β14 days for baseline
Tolerance Decay
Full tolerance
1h
Half tolerance
10d
Baseline
~14d
Acute tolerance: develops within a single session β the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Effects
Positive
- Stimulation
- Mental/physical stimulation
- Spontaneous tactile sensations
Negative
- Pupil Dilation
- Increased Heart Rate
- Muscle Tension
- Vasoconstriction
- Physical Discomfort
- Restlessness
- Sweating/chills
- Insomnia
- Muscle spasms
- Nausea
- Temperature Dysregulation
- Decreased appetite
Positive
- Thought Connectivity
- Novelty Enhancement
- Conceptual Thinking
- Immersion Enhancement
- Increased Sense Of Humor
- Mindfulness
- Wakefulness
- Euphoria
- Empathy
- Insight
- Emotion enhancement
Negative
- Memory Suppression
- Confusion
- Delusions
- Thought disorganization
- Thought loops
- Thought Acceleration
- Time Distortion
- Personal Bias Suppression
- Change in perception
- Ego softening
- Perspective alterations
Positive
- Enhanced Color
- Increased Music Appreciation
- Tracers
- Colour Shifting
- Brightened colour
- Enhanced tactile sensation
- Acuity enhancement
- Auditory enhancement
- Bodily control enhancement
- Colour enhancement
- Pattern recognition enhancement
- Tactile enhancement
- Drifting
- After Images
- Symmetrical Texture Repetition
- Scenery Slicing
- Closed/Open eye visuals
- Auditory distortion
- Auditory hallucinations
- Autonomous entities
- External hallucinations
- Internal hallucinations
Combinations
Cross-Check Escaline with another substanceTrip Reports
Community Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.
Erowid 2 reports 2 neutral visit
[This report originally appeared as a typewritten page pasted into Book 3, page 365 of the Shulgin Lab Books.] Experiment: Escaline, 40 mg for EAM and 60 mg for CM 7/4/80 Procedure: The materials were ingested at 12:30 PM two hours after a light breakfast.
Bluelight 3 threads 3 neutral visit
Age: 21 Weight: 120 lbs Dosage: 100 mg oral in gel cap Setting: My apartment T0:00- Dose taken. Feeling a bit anxious over the purported body load from this drug. I have prepared for myself a very intensely flavored brew of lemon extract and fresh ginger.
50 mg This report will be quite short because of the following reasons. I don't usually write reports and the experience was somewhat mild, so I don't really have too much interesting stuff to tell. I also didn't bother to take detailed notes.
Okay i am just coming down off of a 60mg dose of this stuff, i also did 10mg sublingually which didn't seem to make a difference in onset at least. +0.00: feel really happy, excited and ready to trip! Dose 60mg capsule and 10mg under tongue.
Bluelight Reference Guide
The Big & Dandy Escaline Thread
I'm considering trying this stuff in the next few weeks. Does anyone have experience with escaline? How similar is it to mescaline? I love mescaline, but it's such a pain to extract. I would love to find something similar that's easier to acquire.
Read full thread on Bluelight βPiHKAL / TiHKAL
PiHKAL #72: E
“This is a powerful and complex intoxicantβI could not have coordinated any rational muscular activity. I could not walk; I could not tie my shoe-laces. There is analgesia and an incoordination that I cannot shake. My menstrual flow started a bit ahead of time, but it was light.”
Escaline's nerd page
Pharmacology, chemical data, effect profiles, and more
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Helpful Links
Report an issue or suggest an edit
Spotted incorrect or dangerous information, have a correction, a new study, or a useful addition for Escaline? Let us know. Reports are reviewed by moderators — this is not posted publicly.