Etizolam
Aliases: Etiz, Towa, Zoly, Depas, Lamet, etizest, etilaam, sedekopan, etizola, inxity
Categories
Summary
Etizolam is not approved for medical use in many countries but is prescribed in some (e.g., Japan, India) for anxiety and insomnia. It is 6-10 times more potent than diazepam milligram for milligram. Overdose risk increases significantly when combined with other depressants, particularly opioids and alcohol. Many illicitly-obtained etizolam products lack quality control and may contain variable doses. Compulsive redosing is common due to rapid onset and amnesic effects.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 0.5-1mg | 1-2mg | 2-5mg | 5mg+ |
| Sublingual | 0.5-1mg | 1-2mg | 2-5mg | 5mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects | Total |
|---|---|---|---|---|---|---|
| Oral | 15-30 min | 30-60 min | 2-3 hrs | 1.5-2.5 hrs | 6-24 hrs | 300-0 min |
| Sublingual | 10-20 min | 20-45 min | 2-3 hrs | 1.5-2.5 hrs | 6-24 hrs | 300-0 min |
Tolerance
Build-up
develops over 1–4 weeks of daily use (thienodiazepine with full benzodiazepine cross-tolerance)
Reset
weeks to months depending on half-life and duration of use; taper recommended
Cross-tolerance
Effects
Positive
- Muscle relaxation
- Physical euphoria
- Anxiolytic
- Muscle relaxant
Negative
- Respiratory depression
- Temporary erectile dysfunction
- Sedation
- Hypnotic
- Sedative
- Dystaxia
Positive
- Anxiety suppression
- Cognitive euphoria
Negative
- Motor control loss
- Memory suppression
- Delusions of sobriety
- Compulsive redosing
- Emotion suppression
- Amnesia
- Analysis suppression
- Delusions
- Dizziness
- Information processing suppression
- Thought deceleration
Positive
- Increased libido
- Appetite enhancement
- Increased music appreciation
Negative
- Disinhibition
- Visual acuity suppression
- Acuity suppression
- Dehydration
- Light sensitivity
- Dulled perception
- Perception of bodily heaviness