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    Disclaimer
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.
    ⚠ Benzodiazepines can cause physical dependence with regular use. Withdrawal can be life-threatening. Never combine with opioids or alcohol.

    Fluclotizolam

    Depressant Research-chemical Benzodiazepine

    Summary TheDrug.Wiki TripSit

    Fluclotizolam is a potent thienotriazolodiazepine approximately 3 times stronger than etizolam with a shorter half-life, leading to pronounced rebound insomnia and anxiety. First synthesized in 1979 but never marketed; emerged as a designer drug in 2017. Without medical oversight it poses serious overdose and dependence risks, particularly when combined with other depressants.

    Dose Information TheDrug.Wiki TripSit

    ROA Light Common Strong Heavy
    Oral / Sublingual 250ug 250-500ug 500-750ug 750ug+
    Oral 250ug 250-500ug 500-750ug 750ug+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit

    ROA Onset Peak Offset After Effects Total
    Oral / Sublingual 10-30 min 1-3 hrs 2-4 hrs 1-36 hrs 3.2-7.5 hrs
    Insufflated 5-15 min 1-3 hrs 2-4 hrs 1-36 hrs 3.1-7.2 hrs
    Rectal 10-30 minutes 1-3 hrs 2-4 hrs 1-36 hrs 13-7 hrs
    Oral 10-30 min 3-6 hrs - 1-14 hrs 3.2-6.5 hrs

    Effect Profile

    1 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Benzodiazepine 8.0
    Intense 8/10

    Strong anxiolysis and euphoria with mild sedation and cognitive impairment

    Anxiolysis ×3
    10
    anxiolysis anxiety suppression anxiolytic muscle relaxation emotion suppression
    Sedation / Relaxation ×2
    5
    sedation muscle relaxation
    ⚠ Motor / Cognitive Impairment ×1
    4
    amnesia delusions of sobriety
    Euphoria / Mood Lift ×1
    10
    cognitive euphoria physical euphoria disinhibition
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Fluclotizolam
    View methodology →

    Tolerance

    Build-up develops over 1–4 weeks of daily use; hypnotic tolerance faster than anxiolytic tolerance
    Reset weeks to months depending on half-life and duration of use; taper recommended

    Tolerance Decay

    Full tolerance 5d Half tolerance 3d Baseline ~14d

    Rapid tolerance accumulation is typical with short-acting, high-potency benzos; intermittent spacing (≥2–3 weeks) best limits tolerance and withdrawal risk.

    Cross-Tolerances

    all benzodiazepines
    80%
    z-drugs
    50%

    Effects TheDrug.Wiki

    Positive
    • Anxiolysis
    • Muscle relaxation
    • Physical euphoria
    • Anxiolytic
    Negative
    • Respiratory depression
    • Motor impairment
    Neutral
    • Sedation
    • Sedative
    • Dystaxia
    • Hypnotic
    Positive
    • Anxiety suppression
    • Cognitive euphoria
    Negative
    • Amnesia
    • Thought deceleration
    • Delusions of sobriety
    • Compulsive redosing
    • Delusions
    • Emotion suppression
    • Dizziness
    Neutral
    • Hypnotic effects
    Positive
    • Increased libido
    • Appetite enhancement
    • Increased music appreciation
    Negative
    • Disinhibition
    • Visual acuity suppression
    • Acuity suppression
    • Dehydration
    • Light sensitivity
    Neutral
    • Dulled perception
    • Perception of bodily heaviness

    Combinations TripSit

    Fluclotizolam's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

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