Summary
Fluclotizolam is a potent thienotriazolodiazepine approximately 3 times stronger than etizolam with a shorter half-life, leading to pronounced rebound insomnia and anxiety. First synthesized in 1979 but never marketed; emerged as a designer drug in 2017. Without medical oversight it poses serious overdose and dependence risks, particularly when combined with other depressants. Volumetric dosing from lab-weighed solutions is strongly advised due to its extreme potency and product inconsistency. Forum reports stress setting strict dosing limits and avoiding daily use to prevent tolerance and severe withdrawal.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral / Sublingual | 250ug | 250-500ug | 500-750ug | 750ug+ |
| Oral | 250ug | 250-500ug | 500-750ug | 750ug+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | After Effects | Total |
|---|---|---|---|---|---|
| Oral / Sublingual | 10-30 min | 1-3 hrs | 2-4 hrs | 1-36 hrs | 180-0 min |
| Insufflated | 5-15 min | 1-3 hrs | 2-4 hrs | 1-36 hrs | 180-0 min |
| Rectal | 600-0 min | 1-3 hrs | 2-4 hrs | 1-36 hrs | 180-0 min |
| Oral | 10-30 min | 3.0-6.0 hrs | - | 1.0-14.0 hrs | 180-0 min |
Tolerance
Build-up
develops over 1โ4 weeks of daily use; hypnotic tolerance faster than anxiolytic tolerance
Reset
weeks to months depending on half-life and duration of use; taper recommended
Effects
Positive
- Anxiolysis
- Muscle relaxation
- Physical euphoria
- Anxiolytic
Negative
- Respiratory depression
- Motor impairment
- Sedation
- Sedative
- Dystaxia
- Hypnotic
Positive
- Anxiety suppression
- Cognitive euphoria
Negative
- Amnesia
- Thought deceleration
- Delusions of sobriety
- Compulsive redosing
- Delusions
- Emotion suppression
- Dizziness
- Hypnotic effects
Positive
- Increased libido
- Appetite enhancement
- Increased music appreciation
Negative
- Disinhibition
- Visual acuity suppression
- Acuity suppression
- Dehydration
- Light sensitivity
- Dulled perception
- Perception of bodily heaviness