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    Disclaimer
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.
    ⚠ Benzodiazepines can cause physical dependence with regular use. Withdrawal can be life-threatening. Never combine with opioids or alcohol.

    Fluclotizolam Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 2 corroborating sources
    • 1 ROA with full dose ladder
    • duration data present
    • 17 combo interactions documented
    • classified Tentative
    • classified Research-chemical

    Depressant Research-chemical Benzodiazepine

    Summary dose.wiki TripSit

    Fluclotizolam is a thienotriazolodiazepine, a benzodiazepine-class depressant that first appeared as a designer drug in 2017 despite having been first synthesized in 1979 and never marketed. It is potent, estimated at roughly 3 times stronger than etizolam, and has a comparatively short half-life that can lead to pronounced rebound insomnia and anxiety. Without medical oversight it poses serious overdose and dependence risks, particularly when combined with other depressants.

    Dose Information dose.wiki TripSit

    ROA Light Common Strong Heavy
    Oral / Sublingual 250ug 250-500ug 500-750ug 750ug+
    Light Common Strong Heavy

    Onset, Duration & After-effects dose.wiki TripSit

    ROA Onset Peak Offset After Effects Total
    Oral / Sublingual 10-30 min 1-3 hrs 2-4 hrs 1-36 hrs 3-6 hrs
    Insufflated 5-15 min 1-3 hrs 2-4 hrs 1-36 hrs 3-6 hrs
    Rectal 10-30 min 1-3 hrs 2-4 hrs 1-36 hrs 3-6 hrs

    Effect Profile

    1 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Benzodiazepine 8.0
    Intense 8/10

    Strong anxiolysis and euphoria with mild sedation and cognitive impairment

    Anxiolysis ×3
    10
    anxiolysis anxiety suppression anxiolytic muscle relaxation emotion suppression
    Sedation / Relaxation ×2
    5
    sedation muscle relaxation
    ⚠ Motor / Cognitive Impairment ×1
    4
    amnesia delusions of sobriety
    Euphoria / Mood Lift ×1
    10
    cognitive euphoria physical euphoria disinhibition
    Based on reports from:
    Erowid Experience Reports
    View methodology →

    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track Fluclotizolam there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    Name
    Fluclotizolam
    Unit
    mg
    Description 
    Fluclotizolam
Source: SubstanceSearch (substancesearch.com)

Oral / Sublingual dose (mg): threshold 0.05 · light 250ug · common 250-500ug · strong 500-750ug · heavy 750ug+
Insufflated dose (mg): threshold 0.05
Rectal dose (mg): threshold 0.1

Oral / Sublingual duration: onset 10-30m · peak 1-3h · offset 2-4h · total 3-6h · after-effects 1-36h
Insufflated duration: onset 5-15m · peak 1-3h · offset 2-4h · total 3-6h · after-effects 1-36h
Rectal duration: onset 10-30m · peak 1-3h · offset 2-4h · total 3-6h · after-effects 1-36h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 0.38 mg (Oral / Sublingual).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.

    Tolerance

    Build-up develops over 1–4 weeks of daily use; hypnotic tolerance faster than anxiolytic tolerance
    Reset weeks to months depending on half-life and duration of use; taper recommended

    Tolerance Decay

    Full tolerance 5d Half tolerance 14d Baseline ~60d

    Rapid tolerance accumulation is typical with short-acting, high-potency benzos; intermittent spacing (≥2–3 weeks) best limits tolerance and withdrawal risk.

    Cross-Tolerances

    all benzodiazepines
    80%
    z-drugs
    50%

    Effects dose.wiki

    Positive
    • Anxiolysis
    • Muscle relaxation
    • Physical euphoria
    • Anxiolytic
    Negative
    • Respiratory depression
    • Motor impairment
    Neutral
    • Sedation
    • Sedative
    • Dystaxia
    • Hypnotic
    Positive
    • Anxiety suppression
    • Cognitive euphoria
    Negative
    • Amnesia
    • Thought deceleration
    • Delusions of sobriety
    • Compulsive redosing
    • Delusions
    • Emotion suppression
    • Dizziness
    Neutral
    • Hypnotic effects
    Positive
    • Increased libido
    • Appetite enhancement
    • Increased music appreciation
    Negative
    • Disinhibition
    • Visual acuity suppression
    • Acuity suppression
    • Dehydration
    • Light sensitivity
    Neutral
    • Dulled perception
    • Perception of bodily heaviness

    Combinations TripSit

    Cross-Check Fluclotizolam with another substance

    Community Trip Reports

    Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.

    Erowid 1 report 1 cautionary visit
    Novel Chemical Not So Novel Effects cautionary exp #111261

    I received some fluclotizolam blotters and was extremely excited to try this new chemical out as I had not even tried a benzo in almost a entire year. I have vast experience with many different benzodiazipines and I was very curious how this one would rank next to etizolam.

    brokenphone
    Fluclotizolam's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 dose.wiki 📖 TripSit 📖 PsychonautWiki