Flunitrazolam is a novel lesser-known depressant substance of the benzodiazepine class. It has been noted for its unusual potency for a benzodiazepine compound, being active in the low microgram range. This trait is also shared by compounds such as flubromazolam and clonazolam.
Build-updevelops over 1β4 weeks of daily use; hypnotic tolerance faster than anxiolytic tolerance
Resetweeks to months depending on half-life and duration of use; taper recommended
Tolerance Decay
Full tolerance
3dHalf tolerance
7dBaseline
~28d
Tolerance to sedation/anxiolysis can build within several consecutive days of use and declines over 1β4 weeks of abstinence; estimates are generalized from benzodiazepine class guidance and HR resources rather than drugβspecific studies.