Fosazepam
Summary
Fosazepam is a water-soluble phosphate ester derivative of diazepam with approximately 10-fold lower potency (100 mg fosazepam equals 10 mg diazepam). It is a prodrug that is metabolized to desmethyldiazepam (nordiazepam), which has a very long elimination half-life of approximately 72 hours. This long-acting metabolite can cause extended sedation and accumulation with repeated dosing.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 30-50mg | - | - | - |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset |
|---|---|---|---|---|
| Oral | 30-90 min | 1-2 hrs | 2-4 hrs | 4-8 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong euphoria with moderate anxiolysis and sedation, mild cognitive impairment
Tolerance
Tolerance Decay
Benzodiazepine tolerance can develop within 1–4 weeks of frequent/daily use and decays over weeks to months after cessation. Cross‑tolerance within the benzodiazepine class is substantial; partial cross‑tolerance with Z‑drugs is expected. Data are based on class-level observations and anecdotal reports rather than fosazepam-specific studies.
Cross-Tolerances
Effects
- Muscle relaxation
- Stimulation
- Physical Euphoria
- Motor impairment
- Nausea
- Increased heart rate
- Increased blood pressure
- Increased perspiration
- Vasoconstriction
- Sedation
- Anxiety suppression
- Wakefulness
- Cognitive Euphoria
- Amnesia
- Drowsiness
- Motor control loss
- Thought deceleration
- Emotion suppression
- Anxiety
- Time Distortion
- Increased libido
- Tactile Enhancement
- Increased Music Appreciation
- Pattern Recognition Enhancement
- Disinhibition
- Appetite suppression
- Light sensitivity
- Dulled perception
- Auditory hallucination
- Auditory distortion