Summary
GABA, also known as gamma-aminobutyric acid, is the main inhibitory neurotransmitter. Drugs targeting GABA include benzodiazepines, barbiturates, alcohol and GHB/GBL.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 200-400mg | 400-800mg | 800-1600mg | 1600mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | After Effects |
|---|---|---|---|
| Oral | 15-60 min | 5.0-8.0 hrs | 1.0-2.0 hrs |
Tolerance
Build-up
develops over 1–4 weeks of daily use; hypnotic tolerance faster than anxiolytic tolerance
Reset
weeks to months depending on half-life and duration of use; taper recommended
Effects
Positive
- Physical euphoria
- Muscle relaxation
- Anxiolytic
Negative
- Motor impairment
- Nausea
- Respiratory depression
- Sedation
- Sedative
- Dystaxia
- Itchiness
Positive
- Reduced anxiety
- Anxiety suppression
- Cognitive euphoria
- Euphoria
Negative
- Dizziness
- Compulsive redosing
- Amnesia
- Thought deceleration
- Motor control loss
- Constipation
Positive
- Increased music appreciation
- Increased libido
Negative
- Disinhibition
- Appetite suppression
- Dehydration
- Light sensitivity
- Double vision
- Acuity suppression
- Dulled perception
- Internal hallucinations