Summary
Heroin is highly illegal in most countries and carries extreme overdose risk due to variable purity, fentanyl contamination, and rapid tolerance development. Street heroin ranges from 5-95% purity making accurate dosing nearly impossible. After any period of abstinence, tolerance drops dramatically and previous doses become potentially fatal. Always use with naloxone available, never use alone, test substances when possible, and employ proper harm reduction practices. Medical diamorphine is used only in certain countries for severe pain management.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Intravenous | - | 5-8mg | 8-15mg | 15mg+ |
| Insufflated | 7.5-20mg | 20-35mg | 35-50mg | 50mg+ |
| Smoked | 5-15mg | 15-25mg | 25-50mg | 50mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects | Total |
|---|---|---|---|---|---|---|
| Intravenous | 0-1 min | 1-2 min | 1-90 min | 1-3 hrs | 1.5-3 hrs | 180-0 min |
| Insufflated | 2-10 min | 10-20 min | 30-90 min | 2-4 hrs | 12 hrs | 180-0 min |
| Smoked | 0-0 min | 1-3 min | 15-30 min | 2-3 hrs | 12 hrs | - |
Tolerance
Build-up
develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
Reset
7โ14 days for partial reset; full reset may take weeks โ tolerance loss greatly increases overdose risk
Cross-tolerance
Effects
Positive
- Physical euphoria
- Pain relief
- Muscle relaxation
- Analgesia
- Cough suppression
Negative
- Respiratory depression
- Nausea
- Dry Mouth
- Sedation
- Pupil constriction
- Itchiness
- Relaxant
- Difficulty urinating
Positive
- Cognitive euphoria
- Anxiety suppression
- Dream potentiation
- Euphoria
- Mood lift
- Cognitive Euphoria
- Anxiety Suppression
Negative
- Constipation
- Compulsive redosing
- Dizziness
Positive
- Warmth
- Visual geometry
Negative
- Appetite suppression
- Decreased Libido
- Appetite Suppression
- Spatial disorientation
- Internal hallucination
- Internal hallucinations
- Dulled perception
- Visual and auditory hallucinations