Home
    Disclaimer
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    HXE

    Aliases: Hydroxetamine, 3-hydroxy-2-oxo-pce, O-desmethyl methoxetamine

    Categories

    Dissociative Research-chemical
    HXE structure

    Summary TheDrug.Wiki PsychonautWiki

    HXE is a novel arylcyclohexylamine structurally related to MXE and ketamine. Limited human data exists; approach with caution and harm reduction practices. Low water solubility makes intranasal use caustic; oral administration produces fuller effects. Historical mislabeling and synthesis difficulties mean reagent testing or analytical confirmation is advisable. May trigger false-positive PCP results on urine screens.

    Dose Information TheDrug.Wiki PsychonautWiki

    ROA Light Common Strong Heavy
    Oral 30-60mg 60-100mg 100-130mg 130mg+
    Insufflated 20-40mg 40-70mg 70-120mg 120mg+
    Sublingual 30-60mg 60-100mg 100-130mg 130mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki PsychonautWiki

    ROA Onset Comeup Peak Offset After Effects
    Oral 40-90 min 30-60 min 1.5-2.5 hrs 1-2 hrs 2-12 hrs
    Insufflated 5-20 min 15-30 min 1.5-2.5 hrs 1-2 hrs 2-12 hrs
    Vaporized 1-5 min 5-15 min 0.75-2 hrs 30-60 min 1-6 hrs
    Sublingual 18-60 min 30-60 min 2-4 hrs 2-6 hrs 1-12 hrs

    Tolerance

    Build-up develops with repeated use over days to weeks
    Reset 2–4 weeks for noticeable reduction
    Cross-tolerance
    Ketamine Dextromethorphan PCP Methoxetamine 3-MeO-PCP 3-HO-PCP 3-MeO-PCE 3-HO-PCE

    Effects TheDrug.Wiki

    Positive
    • Stimulation
    • Pain Relief
    • Physical euphoria
    • Pain relief
    Negative
    • Nausea
    • Numbness
    • Loss of balance
    Neutral
    • Sedation
    • Tactile Disconnection
    • Physical disconnection
    Positive
    • Cognitive Euphoria
    • Anxiety Suppression
    • Immersion Enhancement
    • Introspection
    • Conceptual Thinking
    Negative
    • Compulsive Redosing
    • Depersonalization
    • Derealization
    • Memory Suppression
    • Motor Control Loss
    • Dizziness
    Neutral
    • Time Distortion
    • Physical Autonomy
    • Perspective Distortions
    • Consciousness Disconnection
    Positive
    • Increased Music Appreciation
    • Bodily Lightness
    Negative
    • Disinhibition
    • Tactile Suppression
    • Spatial Disorientation
    • Visual Acuity Suppression
    • Double Vision
    • Pattern Recognition Suppression
    Neutral
    • Spontaneous Physical Sensations
    • Internal Hallucination
    • External Hallucination
    • Visual Disconnection

    Combinations TripSit

    Helpful Links

    📘 Experience Reports 📖 PsychonautWiki