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    Disclaimer
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    HXE Well-documented
    Well-documented
    Multiple authoritative sources agree on dosing and effects.
    • 3 corroborating sources
    • 3 ROAs with full dose ladders
    • duration data present
    • 18 combo interactions documented
    • toxicity data (PsychonautWiki)
    • classified Research-chemical

    Aliases: Hydroxetamine, 3-hydroxy-2-oxo-pce, O-desmethyl methoxetamine

    Dissociative Research-chemical

    Summary dose.wiki PsychonautWiki

    HXE is a novel arylcyclohexylamine structurally related to MXE and ketamine. Limited human data exists; approach with caution and harm reduction practices. Low water solubility makes intranasal use caustic; oral administration produces fuller effects.

    Perspectives

    “So much was reminiscent of the properties of the abyssal zones of the sea, the darkness, the blueness, the vastness, the immense pressure, the sense of currents and flows and swirls, the sense of being pressed and tossed about by immense masses of creeping fluid. The sense of viscous magma glowing and setting and sinking into the dark, casting a warmth and light that beckons me in. It is a cozy, homely substance, like being in a dimly lit house during a thunderstorm.”

    Dose Information dose.wiki PsychonautWiki

    ROA Light Common Strong Heavy
    Oral 30-60mg 60-100mg 100-130mg 130mg+
    Insufflated 20-40mg 40-70mg 70-120mg 120mg+
    Sublingual 30-60mg 60-100mg 100-130mg 130mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects dose.wiki PsychonautWiki

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 40-90 min 30-60 min 1.5-2.5 hrs 1-2 hrs 2-12 hrs 3.67-7 hrs
    Insufflated 5-20 min 15-30 min 1.5-2.5 hrs 1-2 hrs 2-12 hrs 2.83-5.33 hrs
    Vaporized 1-5 min 5-15 min 0.75-2 hrs 30-60 min 1-6 hrs 1.35-3.33 hrs
    Sublingual 18-60 min 30-60 min 2-4 hrs 2-6 hrs 1-12 hrs 4.8-12 hrs

    Effect Profile

    1 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Dissociative 6.6
    Strong+ 7/10

    Strong dissociative depth, motor impairment, and mania with moderate insight

    Dissociative Depth ×3
    10
    depersonalization derealization consciousness disconnection tactile disconnection physical disconnection visual disconnection +3 more
    ⚠ Mania / Compulsion ×1
    8
    compulsive redosing disinhibition stimulation
    Insight / Novel Thought ×2
    7
    conceptual thinking introspection immersion enhancement perspective distortions
    ⚠ Motor / Sensory Impairment ×1
    10
    motor control loss tactile disconnection physical disconnection tactile suppression numbness spatial disorientation +2 more
    Based on reports from:
    Erowid Experience Reports
    View methodology →

    Add missing routes to PsychonautWiki Journal

    The PsychonautWiki Journal app already has HXE, but its built-in entry only covers Insufflated, Oral, Sublingual. Here are the other routes we have data for. You can't edit a built-in substance, but you can add a Custom Unit for any of these routes to log it.

    ⬇ Download import file Import this file as custom substances and you get "HXE (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Dose & duration (reference) 
    HXE: routes the PsychonautWiki Journal app is missing
Source: SubstanceSearch (substancesearch.com)

Vaporized dose (mg): threshold 2-5

Vaporized duration: onset 1-5m · come-up 5-15m · peak 0.75-2h · offset 0.5-1h · total 1.35-3.33h · after-effects 1-6h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Custom Units carry a single dose per route, so the full ranges live in the reference above. A route's suggested dose is the midpoint of its common range. Ranges are harm-reduction guidance, not a prescription.

    Tolerance

    Build-up develops with repeated use over days to weeks
    Reset 2–4 weeks for noticeable reduction

    Tolerance Decay

    Full tolerance 2d Half tolerance 7d Baseline ~30d

    Model is a conservative synthesis from ketamine user reports and harm-reduction sources; high variability exists. Expect near-immediate acute tolerance within a session and partial persistence for days to weeks.

    Cross-Tolerances

    ketamine
    60%
    methoxetamine (MXE)
    60%
    other arylcyclohexylamines
    50%

    Effects dose.wiki

    Positive
    • Stimulation
    • Pain Relief
    • Physical euphoria
    Negative
    • Nausea
    • Numbness
    • Loss of balance
    Neutral
    • Sedation
    • Tactile Disconnection
    • Physical disconnection
    Positive
    • Cognitive Euphoria
    • Anxiety Suppression
    • Immersion Enhancement
    • Introspection
    • Conceptual Thinking
    Negative
    • Compulsive Redosing
    • Depersonalization
    • Derealization
    • Memory Suppression
    • Motor Control Loss
    • Dizziness
    Neutral
    • Time Distortion
    • Physical Autonomy
    • Perspective Distortions
    • Consciousness Disconnection
    Positive
    • Increased Music Appreciation
    • Bodily Lightness
    Negative
    • Disinhibition
    • Tactile Suppression
    • Spatial Disorientation
    • Visual Acuity Suppression
    • Double Vision
    • Pattern Recognition Suppression
    Neutral
    • Spontaneous Physical Sensations
    • Internal Hallucination
    • External Hallucination
    • Visual Disconnection

    Combinations

    Cross-Check HXE with another substance

    HXE's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📘 Experience Reports 📖 dose.wiki 📖 PsychonautWiki