Home
    Disclaimer
    ⚠ Opioids carry significant risk of respiratory depression, physical dependence, and fatal overdose. Never combine with other depressants.

    Imodium Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 2 corroborating sources
    • partial dose data
    • duration data present
    • 19 combo interactions documented
    • PubChem toxicity data
    • dose data not in PW/TripSit (unverifiable)

    Aliases: Fad, Lope, Select, Entrocalm, Immodium a-d

    Depressant Opioid

    Summary TheDrug.Wiki Erowid

    Loperamide is an over-the-counter anti-diarrheal that normally does not cross the blood-brain barrier due to P-glycoprotein efflux. At therapeutic doses (2-16 mg/day), it is safe and effective. High-dose misuse (50-400+ mg) to achieve opioid effects or manage withdrawal is extremely dangerous and has caused numerous deaths from cardiac arrhythmias (QT prolongation, Torsades de Pointes).

    Dose Information TheDrug.Wiki

    ROA Light Common Strong Heavy
    Oral - - - 16+mg(notrecommended)
    Rectal - - - 16+mg(notrecommended)
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki

    ROA Onset Comeup Peak Offset After Effects
    Oral 30-60 min 1-2 hrs 2-5 hrs 12-24 hrs 24-48 hrs
    Rectal 30-60 min 1-2 hrs 2-5 hrs 12-24 hrs 24-48 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Opioid 6.0
    Strong 6/10

    Strong euphoria with moderate itching/nausea, mild pain relief, low sedation

    Euphoria / Warmth ×3
    9
    physical euphoria cognitive euphoria euphoria
    Analgesia ×2
    4
    pain relief
    Sedation / Relaxation ×1
    3
    sedation
    ⚠ Itching / Nausea ×1
    6
    nausea constipation
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Imodium
    View methodology →

    Tolerance

    Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
    Reset 7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk

    Tolerance Decay

    Full tolerance 1d Half tolerance 21d Baseline ~35d

    Effects TheDrug.Wiki

    Positive
    • Pain relief
    • Physical euphoria
    Negative
    • Respiratory depression
    • Abnormal heartbeat
    • Nausea
    • Abdominal discomfort
    Neutral
    • Sedation
    • Itchiness
    • Pupil constriction
    • Impaired motor control
    Positive
    • Cognitive euphoria
    • Anxiety suppression
    • Reduced anxiety
    • Euphoria
    Negative
    • Constipation
    • Confusion
    • Cognitive impairment
    Neutral
    • Dissociation
    • Altered time perception
    • Time distortion
    Positive
    • Visual geometry
    • Increased music appreciation
    • Perception of bodily lightness
    Negative
    • Spatial disorientation
    Neutral
    • Dulled perception
    • Visual and auditory hallucinations
    • Internal hallucination
    • Visual disconnection
    • External hallucination
    • Optical sliding

    Combinations TripSit

    Cross-Check Imodium with another substance

    Pill Identifiers

    1 known pill identifiers on record — view imprints, colors, shapes, and images
    →
    Imodium's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    💊 Pill Identifier 📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki