Imodium
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- partial dose data
- duration data present
- 29 combo interactions documented
- PubChem toxicity data
- dose data not in PW/TripSit (unverifiable)
- 2 corroborating sources
- partial dose data
- duration data present
- 29 combo interactions documented
- PubChem toxicity data
- dose data not in PW/TripSit (unverifiable)
Aliases: Fad, Lope, Select, Entrocalm, Immodium a-d
Summary
Loperamide is an over-the-counter anti-diarrheal that normally does not cross the blood-brain barrier due to P-glycoprotein efflux. At therapeutic doses (2-16 mg/day), it is safe and effective. High-dose misuse (50-400+ mg) to achieve opioid effects or manage withdrawal is extremely dangerous and has caused numerous deaths from cardiac arrhythmias (QT prolongation, Torsades de Pointes).
Dose Information
| ROA | Heavy |
|---|---|
| Oral | 16+ mg (not recommended) |
| Rectal | 16+ mg (not recommended) |
Sources· no ladder identified
Oral
Dose ladder — source not identifiedRectal
Dose ladder — source not identified“High-dose misuse (50-400+ mg) to achieve opioid effects or manage withdrawal is extremely dangerous and has caused numerous deaths from cardiac arrhythmias (QT prolongation, Torsades de Pointes).” — encyclopedia summary
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 30-60 min | 1-2 hrs | 2-5 hrs | 12-24 hrs | 15.5-32 hrs |
| Rectal | 30-60 min | 1-2 hrs | 2-5 hrs | 12-24 hrs | 15.5-32 hrs |
Effect Profile
Scores (0–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong euphoria with moderate itching/nausea, mild pain relief, low sedation
Tolerance
No tolerance chart. Our decay curves for opioids were estimates, and a curve can make tolerance look longer-lasting than it is, which is the dangerous direction.
Opioid tolerance drops fast when you stop, and even a few days off can be enough, so a dose that used to be normal can now stop your breathing. Overdose deaths rise sharply after prison, detox or leaving treatment, and tolerance also falls during a hospital stay. After any break, start with a much smaller amount, try a test dose first, don't use alone, and keep naloxone within reach. Alcohol, benzodiazepines, gabapentinoids and other sedatives make an opioid overdose much more likely.
Sources: FRANK: heroin · National Harm Reduction Coalition · WHO: opioid overdose · Merrall et al. 2010 · Binswanger et al. 2007 · Strang et al. 2003 · FDA 2019: gabapentinoids and breathing
Effects
Effect glossary — · full glossary
- Visual and auditory hallucinations
Combinations
Cross-Check Imodium with another substancePill Identifiers
Helpful Links
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track Imodium there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
Imodium Source: SubstanceSearch (substancesearch.com) Oral dose (mg): threshold 0.5 · heavy 16+ (not recommended) Rectal dose (mg): threshold 0.5 · heavy 16+ (not recommended) Oral duration: onset 0.5-1h · come-up 1-2h · peak 2-5h · offset 12-24h · total 15.5-32h · after-effects 24-48h Rectal duration: onset 0.5-1h · come-up 1-2h · peak 2-5h · offset 12-24h · total 15.5-32h · after-effects 24-48h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
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