Imodium
Aliases: Fad, Lope, Select, Entrocalm, Immodium a-d
Summary
Loperamide is an over-the-counter anti-diarrheal that normally does not cross the blood-brain barrier due to P-glycoprotein efflux. At therapeutic doses (2-16 mg/day), it is safe and effective. High-dose misuse (50-400+ mg) to achieve opioid effects or manage withdrawal is extremely dangerous and has caused numerous deaths from cardiac arrhythmias (QT prolongation, Torsades de Pointes).
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | - | - | - | 16+mg(notrecommended)+ |
| Rectal | - | - | - | 16+mg(notrecommended)+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset |
|---|---|---|---|---|
| Oral | 30-60 min | 1-2 hrs | 2-5 hrs | 12-24 hrs |
| Rectal | 30-60 min | 1-2 hrs | 2-5 hrs | 12-24 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Opioid
6.0
Strong
6/10
Strong euphoria with moderate itching/nausea, mild pain relief, low sedation
Euphoria / Warmth
×3
9
physical euphoria
cognitive euphoria
euphoria
Analgesia
×2
4
pain relief
Sedation / Relaxation
×1
3
sedation
Itching / Nausea
×1
6
nausea
constipation
Based on reports from:
Tolerance
Build-up
develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
Reset
7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk
Tolerance Decay
Full tolerance
1d
Half tolerance
21d
Baseline
~35d
Effects
Positive
- Pain relief
- Physical euphoria
Negative
- Respiratory depression
- Abnormal heartbeat
- Nausea
- Abdominal discomfort
- Sedation
- Itchiness
- Pupil constriction
- Impaired motor control
Positive
- Cognitive euphoria
- Anxiety suppression
- Reduced anxiety
- Euphoria
Negative
- Constipation
- Confusion
- Cognitive impairment
- Dissociation
- Altered time perception
- Time distortion
Positive
- Visual geometry
- Increased music appreciation
- Perception of bodily lightness
Negative
- Spatial disorientation
- Dulled perception
- Visual and auditory hallucinations
- Internal hallucination
- Visual disconnection
- External hallucination
- Optical sliding
Combinations
Pill Identifiers
1
known pill identifiers on record — view imprints, colors, shapes, and images
→
Imodium's nerd page
Pharmacology, chemical data, effect profiles, and more
→