Imodium
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- partial dose data
- duration data present
- 19 combo interactions documented
- PubChem toxicity data
- dose data not in PW/TripSit (unverifiable)
- 2 corroborating sources
- partial dose data
- duration data present
- 19 combo interactions documented
- PubChem toxicity data
- dose data not in PW/TripSit (unverifiable)
Aliases: Fad, Lope, Select, Entrocalm, Immodium a-d
Summary
Loperamide is an over-the-counter anti-diarrheal that normally does not cross the blood-brain barrier due to P-glycoprotein efflux. At therapeutic doses (2-16 mg/day), it is safe and effective. High-dose misuse (50-400+ mg) to achieve opioid effects or manage withdrawal is extremely dangerous and has caused numerous deaths from cardiac arrhythmias (QT prolongation, Torsades de Pointes).
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | - | - | - | 16+ mg (not recommended) |
| Rectal | - | - | - | 16+ mg (not recommended) |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 30-60 min | 1-2 hrs | 2-5 hrs | 12-24 hrs | 15.5-32 hrs |
| Rectal | 30-60 min | 1-2 hrs | 2-5 hrs | 12-24 hrs | 15.5-32 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong euphoria with moderate itching/nausea, mild pain relief, low sedation
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track Imodium there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
Imodium Source: SubstanceSearch (substancesearch.com) Oral dose (mg): threshold 0.5 · heavy 16+ (not recommended) Rectal dose (mg): threshold 0.5 · heavy 16+ (not recommended) Oral duration: onset 0.5-1h · come-up 1-2h · peak 2-5h · offset 12-24h · total 15.5-32h · after-effects 24-48h Rectal duration: onset 0.5-1h · come-up 1-2h · peak 2-5h · offset 12-24h · total 15.5-32h · after-effects 24-48h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Effects
- Pain relief
- Physical euphoria
- Respiratory depression
- Abnormal heartbeat
- Nausea
- Abdominal discomfort
- Sedation
- Itchiness
- Pupil constriction
- Impaired motor control
- Cognitive euphoria
- Anxiety suppression
- Reduced anxiety
- Euphoria
- Constipation
- Confusion
- Cognitive impairment
- Dissociation
- Altered time perception
- Time distortion
- Visual geometry
- Increased music appreciation
- Perception of bodily lightness
- Spatial disorientation
- Dulled perception
- Visual and auditory hallucinations
- Internal hallucination
- Visual disconnection
- External hallucination
- Optical sliding
Combinations
Cross-Check Imodium with another substancePill Identifiers
Helpful Links
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