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    Imodium molecular structure

    Imodium Stats & Data

    Depressant Opioid
    Fad Lope Select Entrocalm Immodium a-d
    PubChem CID 71420
    PubChem
    MW513.5
    FormulaC29H34Cl2N2O2
    IUPAC4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide;hydrochloride
    InChIKeyPGYPOBZJRVSMDS-UHFFFAOYSA-N
    Chemical Class Phenylpiperidine
    Psychoactive Class Depressant

    Measured Affinities

    Guide to PHARMACOLOGY

    Measured binding and functional data for loperamide, curated by the IUPHAR/BPS Guide to PHARMACOLOGY. Each row cites the paper it came from. Lower concentrations mean tighter binding — a value in the sub-nanomolar range indicates a very potent interaction.

    Target Action Measure Value Concentration Species Source
    μ receptor OPRM1 Agonist pKi 9.28 0.525 nM Human PMID 15454210

    Reading this. pKi, pEC50 and pIC50 are negative log molar values, so a higher number means a tighter interaction; the concentration column converts them for you. Values from non-human species are laboratory measurements and do not translate directly to human effect. Receptor affinity is not a dose — it describes what a molecule binds, not how much of it is safe to take.

    Receptor data from the IUPHAR/BPS Guide to PHARMACOLOGY (v2026.2), licensed CC BY-SA 4.0. Matched to this substance by InChIKey.

    Toxicity

    PubChem

    Liver injury risk

    No documented concern

    FDA LiverTox / DILIrank. Reflects published case reports of liver injury, not absolute risk.

    Effect Profile

    Curated
    Opioid 6.0

    Strong euphoria with moderate itching/nausea, mild pain relief, low sedation

    Euphoria / Warmth×3
    9
    Analgesia×2
    4
    Sedation / Relaxation×1
    3
    Itching / Nausea×1
    6

    Tolerance & Pharmacokinetics

    drugs.wiki

    No tolerance chart. Our decay curves for opioids were estimates, and a curve can make tolerance look longer-lasting than it is, which is the dangerous direction.

    Opioid tolerance drops fast when you stop, and even a few days off can be enough, so a dose that used to be normal can now stop your breathing. Overdose deaths rise sharply after prison, detox or leaving treatment, and tolerance also falls during a hospital stay. After any break, start with a much smaller amount, try a test dose first, don't use alone, and keep naloxone within reach. Alcohol, benzodiazepines, gabapentinoids and other sedatives make an opioid overdose much more likely.

    Sources: FRANK: heroin · National Harm Reduction Coalition · WHO: opioid overdose · Merrall et al. 2010 · Binswanger et al. 2007 · Strang et al. 2003 · FDA 2019: gabapentinoids and breathing

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