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    Disclaimer
    โ˜  Nitazene-class opioids are extremely potent, often exceeding fentanyl in strength. Even trace amounts can be fatal. Naloxone should always be on hand.
    ๐Ÿงช This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.
    โš  Opioids carry significant risk of respiratory depression, physical dependence, and fatal overdose. Never combine with other depressants.

    Isotonitazene

    Aliases: Iso, Toni, Nitazene

    Depressant Research-chemical Opioid

    Summary TheDrug.Wiki

    Isotonitazene (CAS 14188-81-9) was first characterized in illicit markets in 2019 and scheduled by the U.S. DEA in 2020. In vitro it shows sub-nanomolar MOR efficacy and produces more prolonged respiratory depression than equipotent fentanyl.

    Dose Information TheDrug.Wiki

    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki

    ROA Onset Peak Offset After Effects
    Insufflated 2-5 min 0.5-2 hrs 2-3 hrs 12-12 hrs
    Oral / Sublingual 15-30 min 1-3 hrs 3-4 hrs 12-12 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Opioid 7.0
    Strong+ 7/10

    Strong euphoria, itching/nausea, and pain relief with low sedation

    Euphoria / Warmth ×3
    10
    physical euphoria intense opioid euphoria cognitive euphoria warmth
    Analgesia ×2
    8
    analgesia pain relief
    Sedation / Relaxation ×1
    3
    sedation
    ⚠ Itching / Nausea ×1
    10
    itching nausea constipation
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Isotonitazene
    View methodology →

    Tolerance

    Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
    Reset 7โ€“14 days for partial reset; full reset may take weeks โ€” tolerance loss greatly increases overdose risk

    Cross-Tolerances

    All full ฮผ-opioid agonists (e.g., fentanyl, heroin)
    90%
    Other nitazenes
    90%

    Effects TheDrug.Wiki

    Positive
    • Analgesia
    • Physical euphoria
    • Pain relief
    Negative
    • Itching
    • Respiratory Depression
    • Nausea
    • Respiratory depression
    Neutral
    • Sedation
    • Miosis
    • Itchiness
    Positive
    • Intense Opioid Euphoria
    • Reduced anxiety
    • Cognitive euphoria
    • Anxiety suppression
    • Wakefulness
    • Motivation enhancement
    Negative
    • Constipation
    • Severe Dysphoria
    • Compulsive redosing
    • Motivation suppression
    Positive
    • Warmth
    • Increased music appreciation
    • Increased libido
    Negative
    • Appetite suppression
    • Light sensitivity
    • Disinhibition
    • Dehydration
    Neutral
    • Dulled perception
    • Internal hallucination
    • Warm flush

    Combinations TripSit

    Isotonitazene's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    ๐Ÿ“˜ Experience Reports ๐Ÿ“– TheDrug.Wiki ๐Ÿ“– PsychonautWiki