Summary
Isotonitazene (CAS 14188-81-9) was first characterized in illicit markets in 2019 and scheduled by the U.S. DEA in 2020. In vitro it shows sub-nanomolar MOR efficacy and produces more prolonged respiratory depression than equipotent fentanyl. Community users warn that Narcan may need repeat dosing. Powder is often tan-brown, poorly water-soluble; volumetric dosing in high-proof ethanol:saline (1 mg/100 mL) is recommended.
Dose Information
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | After Effects |
|---|---|---|---|---|
| Insufflated | 2-5 min | 0.5-2 hrs | 2-3 hrs | 12 hrs |
| Oral / Sublingual | 15-30 min | 1-3 hrs | 3-4 hrs | 12 hrs |
Tolerance
Build-up
develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
Reset
7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk
Effects
Positive
- Analgesia
- Physical euphoria
- Pain relief
Negative
- Itching
- Respiratory Depression
- Nausea
- Respiratory depression
- Sedation
- Miosis
- Itchiness
Positive
- Intense Opioid Euphoria
- Reduced anxiety
- Cognitive euphoria
- Anxiety suppression
- Wakefulness
- Motivation enhancement
Negative
- Constipation
- Severe Dysphoria
- Compulsive redosing
- Motivation suppression
Positive
- Warmth
- Increased music appreciation
- Increased libido
Negative
- Appetite suppression
- Light sensitivity
- Disinhibition
- Dehydration
- Dulled perception
- Internal hallucination
- Warm flush