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    Isotonitazene molecular structure

    Isotonitazene Stats & Data

    Depressant Research-chemical Opioid
    Iso Toni Nitazene
    NPS DataHub
    MW410.52
    FormulaC23H30N4O3
    CAS14188-81-9
    IUPAC2-[2-(4-isopropoxybenzyl)-5-nitro-1H-benzimidazol-1-yl]-N,N-diethylethanamine
    SMILESCCN(CC)CCn1c(Cc2ccc(OC(C)C)cc2)nc2cc(ccc12)N(=O)=O
    InChIKeyOIOQREYBGDAYGT-UHFFFAOYSA-N
    2021/7. Von Benzimidazol abgeleitete Verbindungen; 2022/7. Von Benzimidazol abgeleitete Verbindungen
    Chemical Class Opioid
    Psychoactive Class Depressant
    Half-Life Parent t½ (rat) ~0.4–1.1 h depending on dose; active N-desethyl metabolite contributes to longer functional effects; human elimination not well defined.

    Effect Profile

    Curated
    Opioid 7.0

    Strong euphoria, itching/nausea, and pain relief with low sedation

    Euphoria / Warmth×3
    10
    Analgesia×2
    8
    Sedation / Relaxation×1
    3
    Itching / Nausea×1
    10
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Isotonitazene

    Tolerance & Pharmacokinetics

    drugs.wiki
    Half-Life
    Parent t½ (rat) ~0.4–1.1 h depending on dose; active N-desethyl metabolite contributes to longer functional effects; human elimination not well defined.
    Addiction Potential
    Extremely high – full MOR super-agonist; rapid tolerance and severe withdrawal reported after daily microgram-level use.

    Cross-Tolerances

    All full μ-opioid agonists (e.g., fentanyl, heroin)
    90% ●●○
    Other nitazenes
    90% ●●○

    Harm Reduction

    drugs.wiki

    Isotonitazene (CAS 14188-81-9) was first characterised in illicit markets in 2019 and scheduled by the U.S. DEA in 2020. In vitro and in vivo work shows μ-opioid receptor ‘super-agonism’ and prolonged respiratory depression for its active metabolite N-desethyl isotonitazene versus fentanyl; renarcotisation after naloxone is a concern, so monitor 8–12+ hours and be prepared for repeat antagonist dosing. Drug checking and European monitoring document frequent nitazene involvement in poisonings and counterfeit ‘oxycodone/hydromorphone’ tablets; negative fentanyl test strips do not rule out nitazenes. Where available, use full-spectrum drug checking (e.g., mass spectrometry); FTIR alone may miss <5% constituents and current nitazene-specific strips may not detect all analogues. Microgram potency demands volumetric dosing; avoid weighing tiny amounts directly. For oral/sublingual use, dilute to a low concentration to enable accurate measurement; never inject alcohol/PG-based solutions. Avoid combining with any sedatives. After any abstinence of ≥48 h, markedly reduce dose due to rapid loss of tolerance. Grapefruit and other CYP3A4/CYP2D6 inhibitors can increase effects and overdose risk. If injecting occurs, the safest option is to avoid injection; if not avoided, use sterile water, new equipment, and test a very small ‘allergy dose’ with supervision; never share supplies.

    References

    Drugs.wiki References

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