Summary
JWH-018 is a full CB1 and CB2 agonist with 5-fold higher affinity than THC, eliminating the self-limiting ceiling effect of cannabis. This produces a steep and unforgiving dose-response curve. Unlike THC (a partial agonist), full agonism can cause severe harm including seizures, psychosis, strokes, and cardiac events. Pre-weigh doses on a 0.001g scale; vaporized pure powder reaches peak plasma levels within minutes. Herbal blends may contain variable concentrations (1-50mg/g) with hot spots.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Smoked | 1-2mg | 2-3mg | 3-5mg | 5mg+ |
| Vaporized | 1-2mg | 2-3mg | 3-5mg | 5mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects | Total |
|---|---|---|---|---|---|---|
| Smoked | 1 min | 2-5 min | 5-30 min | 1-2 hrs | 2-6 hrs | 60-0 min |
| Oral | 20-60 min | 30-60 min | 1-2 hrs | 1-2 hrs | 2-6 hrs | - |
| Vaporized | 1 min | 2-5 min | 5-30 min | 1-2 hrs | 2-6 hrs | - |
Tolerance
Build-up
develops over weeks of regular use via CB1 receptor downregulation
Reset
2–4 weeks for most users; heavy users may need longer
Effects
Positive
- Spontaneous tactile sensations
- Pain relief
Negative
- Increased Heart Rate
- Seizure
- Nausea
- Increased heart rate
- Dry mouth
- Sedation
- Vasodilation
- Spontaneous bodily sensations
Positive
- Euphoria
- Thought Connectivity
- Immersion Enhancement
- Emotion Enhancement
Negative
- Anxiety
- Paranoia
- Motor Control Loss
- Memory Suppression
- Analysis Suppression
- Depersonalization
- Derealization
- Panic Attacks
- Psychosis
- Time Distortion
Positive
- Appetite Enhancement
- Perception of Bodily Lightness
- Increased Music Appreciation
- Colour Enhancement
- Appetite enhancement
- Colour enhancement
- Auditory enhancement
Negative
- Acuity Suppression
- Spontaneous Physical Sensations
- Changes in Felt Gravity