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    Disclaimer
    ๐Ÿงช This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.
    โš  Synthetic cannabinoids are far more potent and unpredictable than natural cannabis. They lack a ceiling effect and have been linked to seizures, psychosis, and death.

    JWH-018

    Aliases: Am-678

    Research-chemical Cannabinoid

    Summary TheDrug.Wiki PsychonautWiki

    JWH-018 is a full CB1 and CB2 agonist with 5-fold higher affinity than THC, eliminating the self-limiting ceiling effect of cannabis. This produces a steep and unforgiving dose-response curve. Unlike THC (a partial agonist), full agonism can cause severe harm including seizures, psychosis, strokes, and cardiac events.

    Dose Information TheDrug.Wiki PsychonautWiki

    ROA Light Common Strong Heavy
    Smoked 1-2mg 2-3mg 3-5mg 5mg+
    Vaporized 1-2mg 2-3mg 3-5mg 5mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki PsychonautWiki

    ROA Onset Comeup Peak Offset After Effects Total
    Smoked 1 min 2-5 min 5-30 min 1-2 hrs 2-6 hrs 1.1-2.6 hrs
    Oral 20-60 min 30-60 min 1-2 hrs 1-2 hrs 2-6 hrs -

    Tolerance

    Build-up develops over weeks of regular use via CB1 receptor downregulation
    Reset 2โ€“4 weeks for most users; heavy users may need longer

    Cross-Tolerances

    ฮ”9-THC (cannabis)
    40%
    Other indole SCs (e.g., JWH-073, AM-2201)
    60%

    Effects Erowid Bluelight

    Aggregated from 106 Erowid and 34 Bluelight experience reports

    Positive Effects 28

    Euphoria 29.2% 87%
    Music Enhancement 27.1% 87%
    Stimulation 25.0% 81%
    Tactile Enhancement 21.4% 70%
    Body High 19.3% 88%
    Color Enhancement 15.0% 78%
    Focus Enhancement 15.0% 85%
    Hypersomnia 14.7% 79%
    Empathy 14.3% 85%
    Joy 11.8% 82%
    Closed-Eye Visuals 11.4% 84%
    Introspection 9.3% 78%
    Sociability Enhancement 8.8% 83%
    Insight 5.9% 75%
    Brightness Enhancement 5.9% 82%
    Pain Relief 5.7% 80%
    Creativity Enhancement 5.0% 75%
    Lightness 2.9% 75%
    Awe 2.9% 70%
    Contact-With-Presence 2.9% 75%

    Adverse Effects 68

    Anxiety 56.4% 88%
    Body Load 35.3% 83%
    Visual Distortions 30.0% 77%
    Fear 29.4% 92%
    Confusion 28.6% 87%
    Nausea 28.6% 85%
    Thought Disorganization 23.5% 80%
    Panic 23.5% 91%
    Motor Impairment 21.4% 83%
    Auditory Effects 20.7% 88%
    Thought Acceleration 20.6% 78%
    Dry Mouth 20.6% 84%
    Paranoia 17.6% 86%
    Dizziness 17.6% 88%
    Body Temperature Change 17.6% 85%
    Memory Suppression 16.5% 83%
    Increased Heart Rate 16.0% 70%
    Time Dilation 14.7% 83%
    Pain Enhancement 14.7% 79%
    Tremor 14.7% 89%

    Combinations TripSit

    JWH-018's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    ๐Ÿ“˜ Experience Reports ๐Ÿ“– TheDrug.Wiki ๐Ÿ“– PsychonautWiki ๐Ÿ“– The Drug Users Bible