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    L-Theanine molecular structure

    L-Theanine Stats & Data

    Stimulant Nootropic Supplement
    Theanine N5-ethyl-l-glutamine Gamma-glutamylethylamide L-gamma-glutamylethylamide
    PubChem CID 439378
    NPS DataHub
    MW174.2
    FormulaC7H14N2O3
    CAS3081-61-6
    IUPAC(2''S'')-2-Ammonio-5-(ethylamino)-5-oxopentanoate
    SMILESCCNC(=O)CCC(N)C(=O)[O-].[H+]
    InChIKeyDATAGRPVKZEWHA-YFKPBYRVSA-N
    Chemical Class medicine
    Psychoactive Class Stimulant

    Pharmacology

    DrugBank

    Description

    Theanine, a precursor of ethylamine, is found in green tea. It is under investigation in clinical trial NCT00291070 (Effects of L-Theanine in Boys With ADHD).

    Toxicity

    PsychonautWiki

    Theanine is non-addictive, is not known to cause brain damage, and has an extremely low toxicity relative to dose. There are relatively few physical side effects associated with acute theanine exposure. Various studies have shown that in reasonable doses in a careful context, it presents no negative cognitive, psychiatric or toxic physical consequences. It is strongly recommended that one use harm reduction practices when using this substance.

    Effect Profile

    Curated + 12 Reports
    Stimulant 5.9

    Strong focus with mild euphoria, low stimulation and anxiety/jitters

    Stimulation / Energy×3
    3
    Euphoria / Mood Lift×2
    5
    Focus / Productivity×2
    10
    Anxiety / Jitters×1
    2
    Based on reports from:
    Erowid Experience Reports PsychonautWiki L-Theanine The Drug Users Bible L-Theanine

    Tolerance & Pharmacokinetics

    drugs.wiki

    Tolerance Decay

    Full tolerance 1h Half tolerance 10d Baseline ~14d

    Experience Report Analysis

    Erowid
    12 Reports
    2001–2020 Date Range
    11 With Age Data
    8 Effects Detected

    Demographics

    Gender Distribution

    Age Distribution

    Reports Over Time

    Effect Analysis

    Erowid

    Effects aggregated from 12 experience reports (12 Erowid)

    12 Reports
    8 Effects Detected
    5 Positive
    1 Adverse
    2 Neutral

    Effect Sentiment Distribution

    Confidence Distribution

    Positive Effects 5

    Stimulation 66.7% 70%
    Focus Enhancement 50.0% 70%
    Euphoria 41.7% 70%
    Music Enhancement 25.0% 70%
    Tactile Enhancement 25.0% 70%

    Adverse Effects 1

    Anxiety 83.3% 70%

    Real-World Dose Distribution

    62K Doses

    From 442 individual dose entries

    Oral (n=431)

    Median: 400.0mg 25th: 400.0mg 75th: 400.0mg 90th: 500.0mg
    mg/kg median: 2.893 mg/kg 75th: 7.249

    Form / Preparation

    Most common forms and preparations reported

    Read full reports on Erowid →
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